Effects of coupled application of magnetoelectric activated water and amendments on photosynthetic physiological characteristics and yield of maize in arid regions.

Seeking effective improvement agent control measures to enhance the photosynthetic physiological traits and yield levels of spring maize is crucial for efficient green agriculture in arid regions. Therefore, this study was conducted to clarify the effects of coupling improvement agents under magnetoelectric activated water irrigation conditions on the photosynthetic physiological traits, grain nutrients, and yield of spring maize in the arid region of northwest China. Field experiments were set up with three concentrations of growth regulators: 400 times (G1), 500 times (G2), and 600 times (G3), and three amounts of : 15 kg/ha (R1), 45 kg/ha (R2), and 75 kg/ha (R3), along with a control group CK, making a total of 10 treatments applied in the field experiment.

Novel insights into Cntnap4 in Alzheimer's disease: Intestinal flora interaction.

Alzheimer's disease (AD) is a neurodegenerative disorder with unclear etiology. This study employs single-cell RNA sequencing (scRNA-seq), high-throughput transcriptome sequencing, 16s rRNA sequencing, and animal experiments to investigate the role of the contactin-associated protein like-4 (Cntnap4) gene in AD and its interaction with intestinal flora. We found that Cntnap4 deficiency in AD mice led to increased Tau protein phosphorylation, amyloid-beta plaque accumulation, and neuronal loss.

Functional characterization of the InR/PI3K/AKT signaling pathway in female reproduction of the predatory bug Cyrtorhinus lividipennis (Hemiptera: Miridae).

The insulin signaling (IIS) pathway plays a key role in the regulation of various physiological functions in animals. However, the involvement of IIS pathway in the reproduction of natural enemy insects remains enigmatic. Here, 3 key genes (named ClInR, ClPI3K, and ClAKT) related to IIS pathway were cloned from Cyrtorhinus lividipennis (Reuter) (Hemiptera: Miridae), an important natural enemy in the rice ecosystem.

Ferrostatin-1 post-treatment attenuates acute kidney injury in mice by inhibiting ferritin production and regulating iron uptake-related proteins.

Background: Acute kidney injury (AKI) is a common and serious medical condition with high morbidity and mortality. Recent research has highlighted ferroptosis, a novel form of programmed cell death, as a potential therapeutic target in mitigating renal tubular injury in AKI. Ferrostatin-1, a specific ferroptosis inhibitor, has been demonstrated to prevent renal injury through ferroptosis inhibition.

Adaptive prescribed settling time periodic event-triggered control for uncertain robotic manipulators with state constraints.

In this paper, an adaptive prescribed settling time periodic event-triggered control (APST-PETC) is investigated for uncertain robotic manipulators with state constraints. In order to economize network bandwidth occupancy and reduce computational burden, a periodic event-triggered control (PETC) strategy is proposed to reduce the update frequency of the control signal and avoid unnecessary continuous monitoring. Besides, considering that the maneuverable space of the actual robotic manipulators is often limited, the barrier Lyapunov function (BLF) is applied to deal with the influence of the constraint characteristics on the robotic manipulators.

Investigation on removal of multi-component volatile organic compounds in a two-stage plasma catalytic oxidation system - Comparison of X (X=Cu, Fe, Ce and La) doped MnO catalysts.

MnO-X catalysts (X = Cu, Fe, Ce and La) were prepared based on γ-AlO for the mixture degradation of muti-component volatile organic compounds (VOCs) composed of toluene, acetone, and ethyl acetate. The catalysts were characterized, and the density functional theory (DFT) simulation of ozone adsorption on MnO-X were carried out to investigate the influence of adsorption energy on catalytic performance. The results showed that the removal efficiency (RE) of each VOC component was similarly improved by MnO-X catalysts, and the greatest increase in VOCs' removal efficiency was obtained (7.

African swine fever virus I73R is a critical virulence-related gene: A potential target for attenuation.

African swine fever virus (ASFV) is a large, double-stranded DNA virus that causes a fatal disease in pigs, posing a threat to the global pig industry. Whereas some ASFV proteins have been found to play important roles in ASFV-host interaction, the functional roles of many proteins are still largely unknown. In this study, we identified , an early viral gene in the replication cycle of ASFV, as a key virulence factor.

Evaluation of an I177L gene-based five-gene-deleted African swine fever virus as a live attenuated vaccine in pigs.

African swine fever (ASF) is a highly contagious disease of domestic and wild pigs caused by the African swine fever virus (ASFV). The current research on ASF vaccines focuses on the development of naturally attenuated, isolated, or genetically engineered live viruses that have been demonstrated to produce reliable immunity. As a result, a genetically engineered virus containing five genes deletion was synthesized based on ASFV Chinese strain GZ201801, named ASFV-GZΔI177LΔCD2vΔMGF.

The role of 20E biosynthesis relative gene Shadow in the reproduction of the predatory mirid bug, Cyrtorhinus lividipennis (Hemiptera: Miridae).

Cytorhinus lividipennis is a natural enemy of rice planthoppers and leafhoppers. Improving the fecundity of C. lividipennis will be helpful to improve its control effect on pests.

Degradation of toluene in surface dielectric barrier discharge (SDBD) reactor with mesh electrode: Synergistic effect of UV and TiO deposited on electrode.

Combing with photo-catalysis and photo-catalyst, a surface dielectric barrier discharge (SDBD) reactor with a mesh electrode was applied for toluene degradation and a high mineralization was achieved. The degradation performance comparison between SDBD reactors with a mesh and a spring electrode was carried out as well. A significant improvement in carbon balance and CO selectivity were obtained in mesh SBDB reactor compared with that of spring's one.

MnO/γ-AlO catalysts synergistic double dielectric barrier discharge (DDBD) degradation of toluene, ethyl-acetate and acetone.

MnO/γ-AlO catalysts was combined with double dielectric barrier discharge (DDBD) for degradation of acetone, toluene and ethyl acetate. MnO/γ-AlO catalysts with different Mn loading were synthesized by hydrothermal method. XRD, SEM, XPS and H-TPR were applied to characterize the catalysts.

Robust optimization control for turbidity process with large inertia and time-delay in waterworks.

To address the difficulty of optimizing turbidity process with large inertia and long time delay, a twice-optimal control and construction pruning (TOCCP) strategy is proposed, which can be used to improve the fast stability and strong robustness of industrial process. The new approach owns the advantages of twice optimal control (TOC) and construction pruning (CP) method. The TOC constructs an infinite-dimensional state observer of the system, which can eliminate the influence of time delay on the system.

[Corrigendum] Epithelial mesenchymal transition induced by the CXCL9/CXCR3 axis through AKT activation promotes invasion and metastasis in tongue squamous cell carcinoma.

Subsequently to the publication of this paper, an interested reader drew to the authors' attention that two pairs of data panels containing strikingly similar data were featured in Fig. 4A and B. The authors have re‑examined their data and realized that Fig.

The pH-triggered polyglutamate brush co-delivery of MDR1 and survivin-targeting siRNAs efficiently overcomes multi-drug resistance of NSCLC.

Multi-drug resistance (MDR) is one of the major challenges in the successful chemotherapy of non-small cell lung cancer (NSCLC). Although RNA interference (RNAi) has been widely used to silence resistance-related genes, the effect remains unsatisfactory. In this study, we attempted to overcome MDR of NSCLC by simultaneously interfering with two RNAs that have different functions.

Epithelial mesenchymal transition induced by the CXCL9/CXCR3 axis through AKT activation promotes invasion and metastasis in tongue squamous cell carcinoma.

The present study aimed to assess the induction of epithelial-mesenchymal transition (EMT), invasion, and metastasis by the chemokine CXCL9/receptor CXCR3 axis in tongue squamous cell carcinoma (TSCC), unveiling the underlying mechanisms and providing new insights into the prevention and treatment of oral cancer metastasis. The expression levels of CXCL9 and CXCR3 in TSCC tissue specimens were determined by immunohistochemistry, assessing differences between samples with cervical lymph node metastasis and those without. Moreover, protein expression or activity in the TSCC Cal-27 cell line was controlled by neutralizing antibodies, gene transfection, or knock-out.

Roles of Wnt3a and Dkk1 in experimental periodontitis.

Background/purpose: Periodontitis is an inflammatory, destructive disease caused by periodontal bacteria, and its molecular mechanism remains unclear. The aims of this study are to evaluate the expressions of Wnt3a and Dkk1 in experimental periodontitis (EP) and preliminarily explore their roles in periodontal diseases.

Materials And Methods: A total of 64 six-week-old male Sprague-Dawley rats were randomly divided into a normal group and an EP group.

Mobile Crowd Sensing for Traffic Prediction in Internet of Vehicles.

The advances in wireless communication techniques, mobile cloud computing, automotive and intelligent terminal technology are driving the evolution of vehicle ad hoc networks into the Internet of Vehicles (IoV) paradigm. This leads to a change in the vehicle routing problem from a calculation based on static data towards real-time traffic prediction. In this paper, we first address the taxonomy of cloud-assisted IoV from the viewpoint of the service relationship between cloud computing and IoV.

Epithelial cell-derived micro RNA-146a generates interleukin-10-producing monocytes to inhibit nasal allergy.

The aberrant immunity plays an important role in the pathogenesis of allergic diseases. Micro RNAs (miR) are involved in regulating the immunity in the body. This study aims to test a hypothesis that miR-146a induces the expression of interleukin (IL)-10 in monocytes (Mos).

Identification of proteins interacting with protein kinase C-δ in hyperthermia-induced apoptosis and thermotolerance of Tca8113 cells.

The purpose of the present study was to investigate the differential proteins that interact with protein kinase C‑δ (PKC‑δ) in hyperthermia‑induced apoptosis as well as thermotolerance in Tca8113 cells, and furthermore, to investigate the mechanisms of these processes in tumor cells. Activation of PKC‑δ was previously indicated to be involved in the heat sensitivity and thermal resistance of tongue squamous carcinoma cells. Tca8113 cell apoptosis was induced by incubation at 43˚C for 80 min and the thermotolerant Tca8113 cells (TT‑Tca8113) were generated through a gradient temperature‑elevating method.

Synthesis of Deuterated Benzopyran Derivatives as Selective COX-2 Inhibitors with Improved Pharmacokinetic Properties.

We designed a series of specifically deuterated benzopyran analogues as new COX-2 inhibitors with the aim of improving their pharmacokinetic properties. As expected, the deuterated compounds retained potency and selectivity for COX-2. The new molecules possess improved pharmacokinetic profiles in rats compared to their nondeuterated congeners.

Loss of Drosophila Ataxin-7, a SAGA subunit, reduces H2B ubiquitination and leads to neural and retinal degeneration.

The Spt-Ada-Gcn5-acetyltransferase (SAGA) chromatin-modifying complex possesses acetyltransferase and deubiquitinase activities. Within this modular complex, Ataxin-7 anchors the deubiquitinase activity to the larger complex. Here we identified and characterized Drosophila Ataxin-7 and found that reduction of Ataxin-7 protein results in loss of components from the SAGA complex.

Identification of GZD824 as an orally bioavailable inhibitor that targets phosphorylated and nonphosphorylated breakpoint cluster region-Abelson (Bcr-Abl) kinase and overcomes clinically acquired mutation-induced resistance against imatinib.

Bcr-Abl(T315I) mutation-induced imatinib resistance remains a major challenge for clinical management of chronic myelogenous leukemia (CML). Herein, we report GZD824 (10a) as a novel orally bioavailable inhibitor against a broad spectrum of Bcr-Abl mutants including T315I. It tightly bound to Bcr-Abl(WT) and Bcr-Abl(T315I) with K(d) values of 0.

Dock mediates Scar- and WASp-dependent actin polymerization through interaction with cell adhesion molecules in founder cells and fusion-competent myoblasts.

The formation of the larval body wall musculature of Drosophila depends on the asymmetric fusion of two myoblast types, founder cells (FCs) and fusion-competent myoblasts (FCMs). Recent studies have established an essential function of Arp2/3-based actin polymerization during myoblast fusion, formation of a dense actin focus at the site of fusion in FCMs, and a thin sheath of actin in FCs and/or growing muscles. The formation of these actin structures depends on recognition and adhesion of myoblasts that is mediated by cell surface receptors of the immunoglobulin superfamily.