Publications by authors named "Jianping Zhang"

Trap state engineering has been widely employed to manipulate the dynamics of ion migration in metal halide perovskites (MHPs), a crucial factor associated with the performance and stability of MHP-based devices. However, the specific roles of different trap states remain poorly understood due to their complicated spatial and energetics distributions. Herein, we propose a methodology for independently regulating the distributions of bulk shallow and surface deep trap states in MHPs.

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Epithelial mesenchymal transition (EMT) of lens epithelial cells (LECs) is one of the most important pathogenic mechanisms in lens fibrotic disorders, and the regulatory mechanisms of EMT have not been fully understood. Here, we demonstrate that the cAMP-response element binding protein (CREB) can regulate lens EMT in a phosphorylation-dependent and -independent manners with dual mechanisms. First, CREB-S133 phosphorylation is implicated in TGFβ-induced EMT of mouse LECs and also in injury-induced mouse anterior subcapsular cataract (ASC) model.

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The origins of rice domestication and the beginnings of alcoholic fermentation in China are intriguing research topics, with the Shangshan culture in the Lower Yangzi River region being a focal point of archaeological investigations. This study employs a multiproxy approach (phytolith, starch, and fungi) to analyze microfossil remains associated with pottery vessels from the earliest phase of the Shangshan site (ca. 10,000 to 9,000 cal.

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Article Synopsis
  • - The study examined radiation exposure in 30 patients with gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) treated with [Lu]Lu-DOTA-TATE in China, focusing on radiation safety for patients and healthcare workers.
  • - Researchers measured external dose rates and radiation doses to nurses and surroundings during and after treatment, determining safe contact times for patients' family members and coworkers post-therapy.
  • - The findings established guidelines for when patients can resume daily interactions with others and confirmed that radiation exposure to medical staff and the hospital environment remained below national safety limits.
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Microplastics and nanoplastics (MPs/NPs) are emerging contaminants ubiquitous in the environment. These particles can act as carriers of hydrophobic organic compounds (HOCs), such as chlorpyrifos (CPF), an organophosphorus insecticide. This study investigates the acute toxicity of CPF combined with model polystyrene nanoplastics (PS-NPs) using Daphnia magna as a model organism.

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The phenomenon of antibiotic pollution has emerged as a significant global environmental concern. However, there is a lack of technical research on the effective removal of antibiotics based on the characteristics of the groundwater environment. This paper used micro-nano bubbles (MNBs) enhanced immobilized Chlorella technology to remove ofloxacin (OFLX) from groundwater.

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Introduction: This study presents a systematic approach for en bloc transurethral enucleation of the prostate utilizing a bipolar system (TUEB), evaluating its effectiveness and safety. Furthermore, the research aims to pinpoint risk factors contributing to early stress urinary incontinence (SUI) after undergoing en bloc TUEB.

Methods: The en bloc TUEB procedure is visually demonstrated through images and videos.

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Background: The microbial-gut-brain axis has received much attention in recent years, and regulating intestinal flora can effectively improve sleep disorders, which hints the potential effects of probiotics on sleep disorders, but lack of research evidence for meta-analysis. Therefore, this study aims to quantitatively evaluate the influence of probiotics on sleep disorders and sub-healthy sleep conditions.

Methods: Up to 2023, online databases including Pubmed, Embase, Cochrane library, Web of science have been searched for studies involving adults who consume probiotics or paraprobiotics in controlled trials, during which, changes in subjective and/or objective sleep parameters and contributing factors in sleeping quality are examined.

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Purpose: To establish an explainable F-FDG PET/CT-derived prediction model to identify EGFR mutation status and subtypes (EGFR wild, EGFR-E19, and EGFR-E21) in lung adenocarcinoma (LUAD).

Methods: Baseline F-FDG PET/CT images of 478 patients with LUAD from 2 hospitals were collected. Data from hospital A (n = 390) was randomly split into a training group (n = 312) and an internal test group (n = 78), with data from hospital B (n = 88) utilized for external test.

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Objective: To investigate the effect of tibial rotation on knee and ankle function in the patients with extra-articular distal tibial fractures after minimally invasive plate osteosynthesis (MIPO) treatment.

Methods: A retrospective analysis was conducted on 45 patients with extra-articular distal tibial fractures who underwent MIPO between January 2021 and December 2022. There were 20 males and 25 females, aged from 19 to 68 years (mean, 43.

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Background: The administration of platinum-based drugs such as cisplatin and its derivatives, which are frequently used during clinical chemotherapy, is highly restricted due to the incidence of nephrotoxicity. The present study focused on investigating cisplatin-induced nephrotoxicity from the perspective of energy metabolism, renal transporter expression and urinary toxin accumulation.

Methods: This study investigated cisplatin's toxic effects, including nephrotoxicity, cardiotoxicity, hepatotoxicity, pulmonary toxicity, and splenotoxicity.

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Article Synopsis
  • Many cancer patients do not respond effectively to immune checkpoint inhibitors, making it crucial to predict and monitor these responses.
  • A new PET/CT imaging probe, [Ga]Ga-NOTA-GSI, was tested on 72 gastric cancer patients to see if it could assess treatment effects early in immunotherapy.
  • Results showed that responders had significantly higher imaging parameters (like SUV, TLR, TBR) than nonresponders, indicating the probe could potentially help identify which patients benefit from treatment.
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  • Pulmonary tuberculosis (PTB) is a serious infectious disease, and understanding the immune response to it could aid in developing treatments for drug-resistant cases, particularly by focusing on regulatory T cells (Tregs) which suppress immune responses to the bacteria.
  • The study used flow cytometry to analyze Treg frequency and the expression of key immune molecules (BTLA, HVEM, PD-L1, PD-1) in PTB patients compared to healthy controls, finding an increased presence of Tregs in patients.
  • Interestingly, while BTLA and HVEM levels decreased on Tregs in PTB patients, these changes suggested a complex interaction that may enhance Treg activation, with mechanisms behind this needing further investigation.
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Segmentation of organs at risks (OARs) in the thorax plays a critical role in radiation therapy for lung and esophageal cancer. Although automatic segmentation of OARs has been extensively studied, it remains challenging due to the varying sizes and shapes of organs, as well as the low contrast between the target and background. This paper proposes a cascaded FAS-UNet+ framework, which integrates convolutional neural networks and nonlinear multi-grid theory to solve a modified Mumford-shah model for segmenting OARs.

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Lepus yarkandensis live year-round in harsh desert environments and are less susceptible to enteritis. The living conditions of Oryctolagus cuniculus in captivity were suitable, but they were highly susceptible to death by Gram-negative bacteria infected with inflammatory bowel disease complex.TLR4 is closely related to the occurrence of enteritis, and the neighbor-joining topology based on the 12S rDNA sequences showed that the relationship between O.

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  • - The study developed a CT imaging grading system to assess the severity of upper urinary tract calculi related to kidney infections, using data from 126 patients.
  • - Patients with higher CT grades, particularly those with fever or diabetes, showed significant differences in clinical findings like white blood cell counts and other inflammatory markers.
  • - The research found that a higher CT grade significantly increased the risk of systemic inflammatory response syndrome (SIRS), with a 4.472 times greater risk for each grade increase.
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  • The study explores the potential benefits of probiotics in improving lung function and reducing inflammation in patients with chronic obstructive pulmonary disease (COPD), suggesting a connection between the lungs and gut health.
  • A systematic review analyzed data from three clinical trials and five animal studies, revealing that probiotics significantly improved lung function (%FEV1) and decreased various inflammatory markers in COPD models.
  • The authors conclude that probiotics could be a promising additional treatment for COPD, but stress the need for further clinical trials to fully assess their efficacy and safety.
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Recently, diffusion models have shown considerable promise for MRI reconstruction. However, extensive experimentation has revealed that these models are prone to generating artifacts due to the inherent randomness involved in generating images from pure noise. To achieve more controlled image reconstruction, we reexamine the concept of interpolatable physical priors in k-space data, focusing specifically on the interpolation of high-frequency (HF) k-space data from low-frequency (LF) k-space data.

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CRISPR-Cas9 editing triggers activation of the TP53-p21 pathway, but the impacts of different editing components and delivery methods have not been fully explored. In this study, we introduce a p21-mNeonGreen reporter iPSC line to monitor TP53-p21 pathway activation. This reporter enables dynamic tracking of p21 expression via flow cytometry, revealing a strong correlation between p21 expression and indel frequencies, and highlighting its utility in guide RNA screening.

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The purpose of the analysis was to evaluate if 10 mg naloxone, administered intramuscularly, could reverse or prevent opioid-induced respiratory depression (OIRD), including OIRD associated with the administration of lethal doses of high-potency opioids. A naloxone population pharmacokinetic (PK) model was generated using data from two naloxone auto-injector (NAI) clinical PK studies. Mechanistic OIRD PK-pharmacodynamic (PD) models were constructed using published data for buprenorphine, morphine, and fentanyl.

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Two styryl BODIPY derivatives, BOH and BOE, with different hydrophilic properties, were investigated for their reaction mechanisms in lipid bilayers against aqueous ClO, by both experimental and theoretical methods. Density functional theory (DFT) calculations confirmed their identical conformations in solution. Fluorescence spectra and high-resolution mass spectra corroborated the central vinyl group as a common antioxidation moiety against ClO oxidation.

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The Lysosomal Protein Transmembrane 5 (LAPTM5) is a lysosomal transmembrane protein preferentially expressed in hematopoietic cells. The human LAPTM5 gene is located at position 1p34 and extends approximately 25 kb. Its protein includes five transmembrane domains, three PY motifs, and one UIM.

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Rosemary is one of the most promising, versatile, and studied natural preservatives. Carnosic acid (CA) and carnosol (CARN), as the primary active ingredients of rosemary extracts, have little difference in structure, but their antioxidant activities vary significantly, depending on the system studied. The underlying molecular mechanisms remain unclear.

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