Publications by authors named "Jianping Tao"

Background: Understanding the molecular mechanisms and identifying prognostic markers across various subtypes and stages of prostate cancer (PCa) are crucial for improving therapeutic strategies against the disease. This study focuses on discovering novel immune-related biomarkers that could aid in the evaluation and prognosis of PCa at different stages and serve as promising therapeutic targets.

Methods: Transcriptomic and clinical data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases were analyzed to identify differentially expressed genes (DEGs) linked to PCa progression.

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The relationship between heterogeneity and plant diversity remains unclear in low-resource karst. We made observations at different spatial scales within a fixed plot on abandoned farmland that had been enclosed for 4 years. Species richness was spatially scale dependent, while species evenness remained consistently low across all scales.

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Primary renal neuroendocrine tumors (NETs) are extremely rare among renal malignancies. According to pathological manifestations, carcinoid can be divided into four types: typical carcinoid, atypical carcinoid, large cell and small cell neuroendocrine carcinoma. Primary or secondary retroperitoneal carcinoid is even rarer than renal carcinoid.

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  • Histomonosis is a protozoan disease that affects poultry and causes significant economic losses in China, prompting the development of an attenuated vaccine based on a less virulent strain.
  • Four experiments were conducted to test the viability of the attenuated strain, including comparing different infection routes, doses, and immunization schedules to determine the most effective vaccination strategy.
  • Results indicated that the intracloacal route was more effective than oral administration, particularly with a vaccination dose of 2 × 10 on day 14, which led to better weight gain and fewer health issues in vaccinated chickens.
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Prostate cancer is a prevalent malignant disease among middle-aged and elderly men. Its prevention and detection are significant public health issues. We aimed to construct an interpretable model for predicting death risk in prostate cancer patients.

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The frequency and severity of drought events have increased with climate warming. This poses a significant threat to tree growth and survival worldwide. However, the underlying mechanism of tree growth responses to drought across diverse geographic regions and species remains inconclusive.

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  • Toxoplasma gondii is an opportunistic pathogen that affects warm-blooded vertebrates and can cause serious illness in immunocompromised individuals, but the interactions between its proteins and the host's immune system, especially cGAS-STING signaling, are not well understood.* -
  • The study discovered that the ROP5 protein from the PRU strain enhances cGAS-STING immune responses by interacting with the STING protein and promoting specific post-translational modifications.* -
  • Additionally, ROP5 deficiency in the PRU strain led to weaker immune responses and faster replication in immune cells, highlighting its role in regulating toxoplasmosis and offering potential strategies for prevention and control.*
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  • The circadian system in plants allows them to adapt to day and night cycles, influencing their growth and photosynthesis mechanisms.
  • This study investigates how different light conditions, like normal photoperiods and continuous light, affect the expression of crucial genes involved in the circadian rhythm and photosynthesis of tea plants.
  • Findings indicate that shorter or altered light periods can modify gene expression and impact stomatal behavior, revealing complex interactions between circadian rhythms and photosynthetic efficiency in tea plants.
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is a widespread protozoan parasite approximately infecting one-third of the world population and can cause serious public health problems. In this study, we investigated the protective effect of the attenuated vaccine Pru:Δcdpk2 against acute toxoplasmosis and explored the underlying immune mechanisms of the protection in pigs. The systemic T-cell and natural killer (NK) cell responses were analyzed, including kinetics, phenotype, and multifunctionality (interferon [IFN]-γ, tumor necrosis factor [TNF]-α), and the IFN-γ levels were analyzed in PBMCs.

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  • A study was conducted in Jiangsu Province to assess the infection status and genotypes of a specific pathogen in sheep and goats, analyzing 786 fecal samples from 18 farms across five regions.
  • The overall infection rate was found to be 36.51%, with no significant differences between species or ages, but notable differences were observed based on health conditions.
  • Six genotypes (BEB6, CHG2, CHG3, CHC8, CHG14, and COS-I) were identified, all belonging to a non-zoonotic group in phylogenetic analysis.
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Forest foundation species, vital for shaping community structure and dynamics through non-trophic level interactions, are key to forest succession and sustainability. Despite their ecological importance, the habitat ranges of these species in China and their responses to future climate change remain unclear. Our study employed the optimal MaxEnt model to assess the range shifts and their essential drivers of four typical forest foundation species from three climatic zones in China under climate scenarios, including Acer tegmentosum, Acer pseudo-sieboldianum (temperate zone), Quercus glandulifera (subtropical zone), and Ficus hispida (tropical zone).

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Histomonas meleagridis, an anaerobic intercellular parasite, is known to infect gallinaceous birds, particularly turkeys and chickens. The resurgence of histomonosis in recent times has resulted in significant financial setbacks due to the prohibition of drugs used for disease treatment. Currently, research on about H.

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Hard limestone substrates, which are extensively distributed, are believed to exacerbate drought and increase the difficulty of restoration in vulnerable karst regions. Fissures in such substrates may alleviate the negative effect of drought on plants, but the underlying mechanisms remain poorly understood. In a two-way factorial block design, the growth and photosynthesis of 2-year-old Phoebe zhennan seedlings were investigated in two water availabilities (high versus low) and three stimulated fissure habitat groups (soil, soil-filled fissure and non-soil-filled fissure).

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Sheep and goats serve as crucial hosts for spp. and are primarily responsible for its transmission via the fecal-oral route. This can result in symptoms such as lamb weight loss, diarrhea, and even fatalities, leading to significant economic losses.

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Background: The circadian clock, also known as the circadian rhythm, is responsible for predicting daily and seasonal changes in the environment, and adjusting various physiological and developmental processes to the appropriate times during plant growth and development. The circadian clock controls the expression of the Lhcb gene, which encodes the chlorophyll a/b binding protein. However, the roles of the Lhcb gene in tea plant remain unclear.

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Background: Toxoplasma gondii is an obligate intracellular protozoan parasite that causes severe threats to humans and livestock. Macrophages are the cell type preferentially infected by T. gondii in vivo.

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Article Synopsis
  • * Results indicate a 42.3% overall infection rate, with higher rates found in non-primate mammals (50.0%) compared to birds (26.3%) and primates (31.6%).
  • * A total of 11 parasite species were identified, highlighting potential zoonotic risks, emphasizing the necessity for improved parasite management to ensure the welfare of both animals and human visitors in the zoo.
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Vaccination is an ideal strategy for the control and prevention of toxoplasmosis. However, the thermostability and effectiveness of vaccines limit their application. Here, calcium mineralization was used to fabricate tachyzoites as immunogenic core-shell particles with improved immune response and thermostability.

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Toxoplasma gondii relies heavily on the de novo pyrimidine biosynthesis pathway for fueling the high uridine-5'-monophosphate (UMP) demand during parasite growth. The third step of de novo pyrimidine biosynthesis is catalyzed by dihydroorotase (DHO), a metalloenzyme that catalyzes the reversible condensation of carbamoyl aspartate to dihydroorotate. Here, functional analyses of TgDHO reveal that tachyzoites lacking DHO are impaired in overall growth due to decreased levels of UMP, and the noticeably growth restriction could be partially rescued after supplementation with uracil or high concentrations of L-dihydroorotate in vitro.

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Introduction: Apicomplexan AP2 family of proteins (ApiAP2) are transcription factors (TFs) that regulate parasite growth and development, but little is known about the ApiAP2 TFs in spp. sequence is predicted to encode a ApiAP2 protein (EnApiAP2).

Methods: The cDNAs encoding full-length and truncated EnApiAP2 protein were cloned and sequenced, respectively.

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Background: The durable oocyst wall formed from the contents of wall-forming bodies (WFBs) protects Eimeria parasites from harsh conditions and enhances parasite transmission. Comprehending the contents of WFBs and proteins involved in oocyst wall formation is pivotal to understanding the mechanism of the oocyst wall formation and the search for novel targets to disrupt parasite transmission.

Methods: Total proteins extracted from WFBs and the oocyst wall of Eimeria necatrix were subjected to comparative proteomic analysis using tandem mass tag in conjunction with liquid chromatography tandem-mass spectrometry techniques.

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Gastrointestinal (GI) parasites in small ruminants, especially goats and sheep, have caused significant socio-economic and public health challenges worldwide. The aim of the present study was to investigate the diversity and prevalence of GI parasites in goats and sheep in Jiangsu, Shaanxi and Hunan provinces of China, and to assess whether the age of animals, sampling season and feeding mode influence the distribution and infection of GI parasites. A total of 1,081 fecal samples collected from goats ( = 835) and sheep ( = 246) were detected by saturated saline flotation technique and nylon sifter elutriation and sieving method for eggs/oocysts, respectively.

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Article Synopsis
  • Moso bamboo invasion has significant effects on forest ecosystems by increasing litter decomposition and altering soil properties, such as raising soil pH and nitrogen levels while lowering bulk density and conductivity.
  • A meta-analysis of 72 studies found that moso bamboo invasion enhances certain soil microbial communities, increasing fungal and bacterial diversity, but reduces the biomass of Gram-positive bacteria.
  • The variations in soil properties and microbial responses to moso bamboo invasion are influenced by climatic conditions, topography, and the stage of invasion, indicating a complex relationship between them.
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