Publications by authors named "Jianning Yu"

Article Synopsis
  • - A successful flexible wearable device must maintain long-term comfort and wettability, similar to how tears function in the eye by rapidly spreading and slowly evaporating.
  • - Inspired by the eye's surface, researchers developed a hybrid surface made of a mucin-like hydrophilic layer and hydrogel nanowire arrays, which helps maintain a stable water film for about 10 minutes compared to less effective samples.
  • - By increasing the amount of hydrated water and utilizing the capillary properties of the nanowires, the team created hydrogel-based contact lenses that enhance comfort and visual clarity during extended wear.
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  • PDEVs from plants show benefits like high biocompatibility and skin condition improvement, but traditional extraction methods are complex and impure.
  • A new platform is designed to efficiently purify PDEVs by using gravity to separate samples from impurities without needing electricity.
  • Testing with liquorice-derived extracellular vesicles (LdEVs) demonstrates that this method provides better cell uptake and wound recovery compared to commercial extracts, highlighting its potential for skin aging treatments.
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  • * Twelve new sesquiterpenoids, named salcavalins A-L, were isolated from the plant, and their structures were determined using advanced scientific techniques.
  • * Some salcavalins showed significant biological activities, including anti-inflammatory effects and neuroprotective potential, as well as phytotoxicity against radish seeds, supporting their use in natural medicine.
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Salvia has been regarded as a beneficial healing herb in ancient Egypt, Rome and Greece, and is listed as an official medicine in the pharmacopoeias of many countries worldwide. Currently, Salvia is widely used to flavor and preserve food. Here, two undescribed norabietane-type diterpenoids, sadigitaloides A and B, two undescribed germacrane-type sesquiterpenoids, sadigitaloides C and D, five undescribed guaiane-type sesquiterpenoid lactones, sadigitaloides E-I, two undescribed noreudesmane-type sesquiterpenoids, sadigitaloides J and K, one known diterpenoid, three known sesquiterpenoids, and three other types of known compounds were isolated from the 95% ethanol extract of the whole plants of Salvia digitaloides.

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Kinetic and affinity analysis of protein interactions reveals information on their related activities in biological processes. Herein, we established a system for evaluating the kinetics and affinity of the interaction between protein A and various IgG species on the surface of silica spheres of silica colloidal crystal (SCC) films by the extraordinary optical interference capabilities of 190 nm silica spheres after self-assembly. The equilibrium association constant (KA) was calculated by the equilibrium Langmuir model and nonlinear least-squares analysis of time-dependent data.

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Feeder cells play important roles in In-vitro culture of stem cells. However, the preparation protocol of feeder cells produced by bovine embryonic fibroblast cells (bEFs) is still lack. In this study, the preparation of bEF-feeder by Mitomycin C was optimized with different concentrations and treatment time.

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Ovarian angiogenesis is an extremely rapid process that occurs during the transition from follicle to corpus luteum (CL) and is crucial for reproduction. It is regulated by numerous factors including transforming growth factor-β1 (TGFB1). However, the regulatory mechanism of TGFB1 in ovarian angiogenesis is not fully understood.

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Intense angiogenesis is critical for the development of the corpus luteum and is tightly regulated by numerous factors. However, the exact role transforming growth factor-β1 (TGFB1) plays during this follicular-luteal transition remains unclear. This study hypothesised that TGFB1, acting through TGFB receptor 1 (TGFBR1) and Smad2/3 signalling, would suppress angiogenesis during the follicular-luteal transition.

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This study was designed to investigate the effects of fermented feed diets on the growth performance and cecal microbial community in geese, and to examine associations between the gut microbiota and growth performance. A total of 720 healthy, 1-day-old male SanHua geese were used for the 55-D experiment. Geese were randomly divided into 4 groups, each with 6 replicates of 30 geese.

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The present study aimed to investigate the effect of avicularin on rheumatoid arthritis (RA) , and additionally explore the molecular mechanism. To perform this investigation, an model of RA was established by treatment of the human RA synovial MH7A cell line with tumor necrosis factor-α (TNF-α). MH7A cells were then treated with various concentrations (10, 30, 100 and 300 µM) of avicularin.

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Treatment of fetal rat and embryonic chicken with exogenous glucocorticoids induces premature differentiation of growth hormone (GH) secreting cells. The effect of corticosterone (CORT) on somatotroph differentiation was mostly studied in pituitary cells in vitro. Currently, there is no evidence for glucocorticoid-mediated induction of somatotroph differentiation during pituitary development in bird species other than chicken.

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Current studies have revealed that aging is a negative factor that suppresses granulosa cell functions and causes low fertility in women. However, the difference in gene expression between normal and aging granulosa cells remains undefined. Therefore, the aim of this study was to investigate the gene expression profiles of granulosa cells during aging.

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In asymmetric chick gonads, the left and right female gonads undergo distinct programs during development, generating a functional ovary on the left side only. Despite some progress being made in recent years, the mechanisms of molecular regulation remain incompletely understood, and little genomic information is available regarding the degeneration of the right ovary in the chick embryo testis. In this study, we performed transcriptome sequencing to investigate differentially expressed genes in the left and right ovaries and gene functions at two critical time points; embryonic days 6 (E6) and 10 (E10).

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Article Synopsis
  • Researchers discovered two new TREM genes, AcTREM1 and AcTREM2, in the Chinese goose (Anas cygnoides), which are important for immune responses in macrophages.
  • Both genes feature components like signal peptides and domains that are common in receptor structures, and they are primarily found in the liver and spleen.
  • Expression levels of AcTREM1 increase after lipopolysaccharide (LPS) exposure during early infections, while AcTREM2 shows opposite patterns, suggesting they work together in the antibacterial immune response of these geese.
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This study was carried out to induce out-of-season breeding, in the summer, and to achieve high reproductive performance using artificial photoperiod manipulation in the long-day breeding Yangzhou goose. Young geese were subject to a two-phase short-to-long (group A) or a three-phase (long-short-long; group B) photoperiod program February through October. Egg-laying was induced to start similarly in both groups in May, increased to a peak level in July, and then decreased gradually through to October.

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  • The study focused on how artificial lighting impacts the breeding cycle of the Yangzhou goose, revealing that longer light exposure (up to 12 hours) boosts testis development and testosterone production.
  • Testis and hormone activity peaked two months after the light increase but declined significantly after five months, showing a clear relationship between light duration and reproductive function.
  • The research found that reproductive stimulation is linked to changes in specific hormones and genes in both the hypothalamus and pituitary gland, indicating a complex interaction governing breeding activity in these birds.
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  • The study explores how lipopolysaccharide (LPS) affects the ovary of breeding Chinese geese, particularly its impact on steroid hormone production and the expression of Toll-like receptors, which are crucial for detecting infections.
  • Laying geese received LPS treatment for varying times, and their ovarian tissues were analyzed for changes in gene expression and structural integrity.
  • Findings suggest that LPS treatment alters follicle structure and negatively impacts hormone levels like progesterone and estrogen, indicating that pathogen infection leads to inflammation and lowers egg production by affecting ovarian function.
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  • The study aimed to investigate the effects of coixenolide on regulatory T cells (specifically Foxp3+ CD4+ CD25+ Treg cells) in mice with collagen-induced arthritis (CIA).
  • Mice were divided into different groups, with one receiving coixenolide injections and another receiving normal saline, over a period of 21 days.
  • Results showed that coixenolide significantly reduced the arthritis index and increased Treg levels compared to the model group, suggesting its potential role in immunoregulation during arthritis.
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  • The study aimed to investigate how inhibin affects porcine granulosa cell growth and function, focusing on the cellular mechanisms involved.
  • Treatment with an anti-inhibin alpha subunit antibody increased estradiol secretion and cell proliferation, especially when combined with low doses of follicle-stimulating hormone (FSH), but decreased the effects of FSH at higher doses.
  • The findings suggest that blocking inhibin activity promotes healthy granulosa cell development by enhancing signaling pathways and altering gene expression related to cell growth and survival.
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Objective: To investigate the role of nicotinamide-adenine dinucleotide phosphate (NADPH) oxidasedependent formation of reactive oxygen species (ROS) in the transforming growth factor β1 (TGF-β1)-induced epithelial-mesenchymal transition (EMT) in rat peritoneal mesothelial cells (RPMCs), and the effect of Astragalus injection (AGI) intervention.

Methods: Primary RPMCs were cultured to the second generation in vitro. After synchronization for 24 h, the cells were randomly assigned to the following groups: control (Group A), AGI (2 g/mL; Group B), TGF-β1 (10 ng/mL; Group C), TGF-β1 (10 ng/mL) + AGI (2 g/mL; Group D; pretreated for 1 h with AGI before TGF-β1 stimulation).

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Objective: To observe the effect and mechanism of Chinese medicine therapy for activating blood and dredging collaterals (ABDC) on treating systemic lupus erythematosus complicated with avascular necrosis of the femoral head (SLE-ANFH).

Methods: Thirty-four patients (51 joints) with SLE-ANFH were assigned by a random number table to two groups: 22 patients (32 joints) in the treatment group and 12 patients (19 joints) in the control group. All received Western medical conventional treatment for anti-inflammation and immunosuppression, but an additional Chinese medicine decoction prescribed based on ABDC principle was administered to patients in the treatment group.

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New heteroleptic iridium(III) complexes (ppz)2Ir(LX), which consist of two cyclometalated ligands ppz(1-phenylpyrazole) together with an ancillary ligand LX (LX= 2-(2'-hydroxylphenyl)benzothiazole (BTZ), 2-(3'-methyl-2'-hydroxylphenyl) benzothiazole (3-MeBTZ), 2-(4'-methyl-2'-hydroxylphenyl) benzothiazole (4-MeBTZ) and 2-(4'-Trifluoromethyl-2'hydroxylphenyl) benzothiazole (4-tfmBTZ)), were synthesized and characterized. The molecular structures and photophysical properties were characterized and analyzed comparatively. The results show that the four complexes have basically similar UV-Vis absorption spectra, fluorescence excitation and emission spectra.

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It has been well recognized that a deficit of numbers and function of CD4+CD25+Foxp3+ cells (Treg) is attributed to the development of some autoimmune diseases; however, there are controversial data regarding the suppressive effect of Treg cells on the T cell response in systemic lupus erythematosus (SLE). Additionally, IL-17-producing cells (Th17) have been recently emerged as a new pathogenic cell, but their role in lupus remains unclear. In this study, we studied the connection between Treg and Th17 cells in lupus patients.

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[Epigenetics and cancer].

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi

October 2009

Article Synopsis
  • - Epigenetic modifications, such as DNA methylation and histone changes, influence gene transcription without altering the DNA sequence, making them crucial for gene regulation.
  • - These modifications are heritable but reversible, offering potential therapeutic avenues for cancer treatment by reactivating silenced genes.
  • - The review highlights recent research on how epigenetics affects gene regulation and its link to cancer, as well as the proteins involved in interpreting epigenetic signals.
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5-AZA-2'-deoxycytidine (5-AZA-CdR) is a demethylating, teratogenic agent and a mutagen, which causes defects in the developing mouse and rat after implantation. Our previous data indicated that 5-AZA-CdR (0.2 and 1.

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