Cascade-recharged macrophage-biomimetic ruthenium-based nanobattery for enhanced photodynamic-induced immunotherapy.

Photodynamic-induced immunotherapy (PDI) is often hampered by low reactive oxygen species (ROS) yield, intra-tumor hypoxia, high glutathione (GSH) concentration, and immunosuppressive microenvironment. In view of this, a ruthenium (Ru)-based nanobattery (termed as IRD) with cascade-charged oxygen (O), ROS, and photodynamic-induced immunotherapy by coordination-driven self-assembly of transition-metal Ru, photosensitizer indocyanine green (ICG), and organic ligand dithiobispropionic acid (DTPA). Then, IRD is camouflaged with macrophage membranes to obtain a nanobattery (termed as IRD@M) with targeting and immune evasion capabilities.

Nasal delivery of secretory IgA confers enhanced neutralizing activity against Omicron variants compared to its IgG counterpart.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its multiple variants continue to spread worldwide, causing respiratory symptoms primarily through mucosal infection. The mucosa serves as the primary barrier against viral entry, in which secretory immunoglobulin A (sIgA) plays a critical role in preventing infection. Here, we engineered and characterized a neutralizing monoclonal antibody, ZW2G10, in IgG, monomeric, dimeric, secretory IgA1, and IgA2 formats.

Orally Administrated Inulin-Modified Nanozymes for CT-Guided IBD Theranostics.

Background: Inflammatory bowel disease (IBD) is a chronic inflammatory bowel disease with no clinical cure. Excessive production of reactive oxygen species (ROS) at the inflammatory sites leads to the onset and progression of IBD. And the current non-invasive imaging methods are not ideal for the diagnosis and monitoring of IBD.

Impaired inflammatory resolution with severe SARS-CoV-2 infection in leptin knock out obese hamster.

Comorbidities, such as obesity, increase the risk of severe COVID-19. However, the mechanisms underlying severe illnesses in individuals with obesity are poorly understood. Here, we used gene-edited leptin knock out ( ) obese hamsters to establish a severe infection model.

Mechanism of Astragaloside IV in Promoting Osteogenic Differentiation.

Background: This study focuses on exploring the impact of Astragaloside IV [AS-IV] on osteogenic differentiation.

Methods: Osteogenic differentiation was induced in rat osteoblasts, following which treatment with AS-IV at varied doses was performed. Using Alizarin red staining and alkaline phosphatase [ALP] detection assay, the osteogenic differentiation of the cells was investigated.

Improving movement decoding performance under joint constraints based on a neural-driven musculoskeletal model.

Electromyography-driven musculoskeletal model (E-DMM) connects the user's control commands with the joint positions from a physiological perspective. However, features extracted directly from the surface EMG signals may be affected by signal crosstalk and amplitude cancellation. This limitation can be addressed with the decomposition algorithms for high-density (HD) EMG signals, which demonstrate the capability of extracting neural drives for the human-machine interface.

Reactive Plasma Deposition of ITO as an Efficient Buffer Layer for Inverted Perovskite Solar Cells.

In this study, the potential of reactive plasma deposition (RPD) is demonstrated for fabricating indium tin oxide (ITO) as an efficient buffer layer in inverted wide-bandgap perovskite solar cells (PSCs). This method results in a certified efficiency of 21.33% for wide-bandgap PSCs, demonstrating superior thermal stability and operational stability.

N-Methyladenosine modification mediated by METTL3 promotes DNA-PKcs expression to induce anlotinib resistance in osteosarcoma.

Background: Acquired anlotinib resistance is still a key challenge in osteosarcoma treatment. Unravelling the mechanisms underlying anlotinib resistance is the key to optimising its efficacy for treating osteosarcoma. Previous studies have explored the pivotal function of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) with regard to osteosarcoma chemoresistance.

Instance-level semantic segmentation of nuclei based on multimodal structure encoding.

Background: Accurate segmentation and classification of cell nuclei are crucial for histopathological image analysis. However, existing deep neural network-based methods often struggle to capture complex morphological features and global spatial distributions of cell nuclei due to their reliance on local receptive fields.

Methods: This study proposes a graph neural structure encoding framework based on a vision-language model.

LungDepth: Self-Supervised Multi-Frame Monocular Depth Estimation for Bronchoscopy.

Background: Bronchoscopy is an essential measure for conducting lung biopsies in clinical practice. It is crucial for advancing the intelligence of bronchoscopy to acquire depth information from bronchoscopic image sequences.

Methods: A self-supervised multi-frame monocular depth estimation approach for bronchoscopy is constructed.

TET1 participates in oxaliplatin-induced neuropathic pain by regulating microRNA-30b/Nav1.6.

Chemotherapy-induced neuropathic pain poses significant clinical challenges and severely impacts patient quality of life. Sodium ion channels are crucial in regulating neuronal excitability and pain. Our research indicates that the microRNA-30b (miR-30b) in rat dorsal root ganglia (DRG) contributes to chemotherapy-induced neuropathic pain by regulating the Nav1.

Exploring the Cardioprotective Mechanisms of in Myocardial Infarction Through Network Pharmacology and Experimental Validation.

Background: Myocardial infarction represents a coronary artery ailment with the highest incidence and fatality rates among cardiovascular conditions. However, effective pharmacological interventions remain elusive. This study seeks to elucidate the molecular mechanisms underlying the effects of on myocardial infarction through network pharmacology and experimental validation.

Study on the synergistic hydration mechanism of granulated blast furnace slag-carbide slag-based cementitious materials and the properties of full-solid waste backfill materials.

The synergistic utilization of multiple solid waste is an effective means of achieving green filling and resource utilization of solid waste in mines. In this paper, the synergistic effects of solid waste granulated blast furnace slag (GS) and carbide slag (CS) as cementitious materials (GCCM) are investigated, along with their preliminary feasibility in combination with coal gangue (CG) and furnace bottom slag (FBS) for the preparation of backfill materials. The synergistic hydration mechanism, mechanical properties, working performance of GCCM and GBC were studied, and the environmental impact and cost-effectiveness of GBC were evaluated.

Controlled Inflammation Drives Neutrophil-Mediated Precision Drug Delivery in Heterogeneous Tumors.

Tumor heterogeneity remains a formidable obstacle in targeted cancer therapy, often leading to suboptimal treatment outcomes. This study presents an innovative approach that harnesses controlled inflammation to guide neutrophil-mediated drug delivery, effectively overcoming the limitations imposed by tumor heterogeneity. By inducing localized inflammation within tumors using lipopolysaccharide, it significantly amplify the recruitment of drug-laden neutrophils to tumor sites, irrespective of specific tumor markers.

Innovative Integration of Robotic-Assisted Laparoscopic Telesurgery and Quantum Cryptography Communication in Urology: Clinical Application and Initial Experience.

Background: The emergence of telesurgery has received global interest, with secure network transmission identified as a crucial determinant of its success. This study aimed to evaluate the safety and viability of employing quantum cryptography communication in remote partial nephrectomy.

Methods: The surgeon operated on the patient from a distance of over 260 km using remote control of a surgical robot.

Applications and Future Prospects of Medical LLMs: A Survey Based on the M-KAT Conceptual Framework.

The success of large language models (LLMs) in general areas have sparked a wave of research into their applications in the medical field. However, enhancing the medical professionalism of these models remains a major challenge. This study proposed a novel model training theoretical framework, the M-KAT framework, which integrated domain-specific training methods for LLMs with the unique characteristics of the medical discipline.

Incremental yield of prenatal exome sequencing in fetuses with skeletal system abnormalities: A systematic review and meta-analysis.

Introduction: Fetal skeletal abnormalities can be caused by various factors and genetic cause plays an important role. Prenatal exome sequencing (ES) has been shown to be a powerful approach for accurate prenatal molecular diagnoses. Diagnostic yield of ES in fetal skeletal abnormalities varies significantly across studies.

Single-cell RNA sequencing analysis reveals the role of TXNDC5 in keloid formation.

Objective: Thioredoxin domain-containing protein 5 (TXNDC5) is associated with fibrosis in a variety of organs, but its mechanism of action in keloid is unclear. In this study, we aimed to investigate the mechanism of TXNDC5 in keloid.

Material And Methods: Single-cell RNA sequencing data of keloid and normal scar samples obtained from public databases were normalized and clustered using the Seurat package.

A pan-orthoebolavirus neutralizing antibody encoded by mRNA effectively prevents virus infection.

is a genus of hazardous pathogens that has caused over 30 outbreaks. However, currently approved therapies are limited in scope, as they are only effective against the Ebola virus and lack cross-protection against other orthoebolaviruses. Here, we demonstrate that a previously isolated human-derived antibody, 2G1, can recognize the glycoprotein (GP) of every orthoebolavirus species.

Protection against cigarette smoke-induced chronic obstructive pulmonary disease via activation of the SIRT1/FoxO1 axis by targeting microRNA-132.

Objective: To investigate the biological role of miR-132 in a murine model of chronic obstructive pulmonary disease (COPD) via activation of the SIRT1/FoxO1 axis.

Methods: COPD was induced in C57BL/6J male mice by exposing them to cigarette smoke (CS) for 8 weeks. A miR-132 knockout mouse model was used to assess the role of miR-132 in CS-induced COPD.

Hyperlipidemia exacerbates acute pancreatitis via interactions between P38MAPK and oxidative stress.

Background: The mechanisms involved in the hyperlipidemia-associated acute pancreatitis (HLAP) is not yet fully understood.

Aims: To investigate the role of P38MAPK (mitogen-activated protein kinases) and oxidative stress in the pathogenesis of HLAP.

Methods: In AP (acute pancreatitis) patients, the GEO database retrieved gene expression profiles of cytokines, MAPK14, nuclear factor kappa B subunit 1 (NF-κB 1) and superoxide dismutase 2 (SOD 2).

Efficacy and safety of JMT103 in patients with unresectable or surgically-challenging giant cell tumor of bone: a multicenter, phase Ib/II study.

This was a multicenter, single-arm, open-label, phase Ib/II study (NCT04255576), aimed to evaluate the efficacy and safety of JMT103 in patients with unresectable or surgically-challenging giant cell tumor of bone (GCTB). JMT103 (2 mg/kg) was administered subcutaneously every four weeks, with loading doses on days 8 and 15. The primary endpoint was the objective tumor response rate (OTR) based on best response, defined as the proportion of patients who achieved elimination of at least 90% of the giant cells or radiologic complete or partial response per the modified Inverse Choi density/size (mICDS) or modified European Organization for Research and Treatment of Cancer (mEORTC) within 12 weeks.

Electrochemically-Switched Microwave Response of MXene in Organic Electrolyte.

The increasingly complex electromagnetic (EM) environment necessitates advanced electrically controllable electromagnetic interference (EMI) shielding materials that can adapt to varying EM conditions. This study develops a flexible electrochemically tunable EMI shielding device based on ultrathin TiCT MXene films, exhibiting reversible shielding effectiveness (SE) modulation from 18.9 to 26.