Publications by authors named "Jianlong Deng"
Study Design: This was a retrospective cohort review.
Objective: The objective of this study was to analyze depression using Beck Depression Inventory (BDI) and Hamilton Depression Scale (HAMD-24), and to correlate with clinical outcomes and improvement in adults with following lumbar fusion.
Summary Of Background Data: Psychological factors such as depression are found to influence outcomes and improvement following spinal surgery.
Article Synopsis
- The study investigates biomarkers and pathways linked to hepatocellular carcinoma (HCC) caused by hepatitis B virus (HBV), using datasets from GSE14520 and The Cancer Genome Atlas.
- Differentially expressed genes (DEGs) were identified, leading to the discovery of pathways associated with HCC, including the cell cycle and p53 pathways, with 11 hub DEGs highlighted through weighted gene co-expression network analysis (WGCNA).
- Certain DEGs were linked to poor clinical outcomes and could serve as diagnostic and prognostic biomarkers for HBV-related HCC, potentially improving understanding of hepatocarcinogenesis.
Article Synopsis
- The study aims to identify a competing endogenous RNA (ceRNA) network by analyzing dysregulated RNAs in hepatocellular carcinoma (HCC) using data from The Cancer Genome Atlas (TCGA).
- The research involved examining RNA sequencing data to discover differentially expressed genes (DEGs), microRNAs, and long non-coding RNAs, ultimately identifying key dysregulated RNAs that contribute to a prognostic signature for overall survival (OS) in HCC patients.
- The findings suggest that the constructed ceRNA network and identified prognostic signature serve as independent indicators for HCC patient survival, with significant enrichment in biological processes related to the cell cycle and cell proliferation.
Article Synopsis
- * The variant -rs1057868 is linked to improved overall survival in HBV-related HCC patients, while high mRNA expression also correlates with better outcomes, although neither showed significant effects on recurrence-free survival.
- * Nomograms were created to predict overall survival, and gene set enrichment analysis indicated several gene sets might relate to survival and treatment response in liver cancer.
Background/aims: The aim of the current study was to identify potential prognostic long non-coding RNA (lncRNA) biomarkers for predicting survival in patients with hepatocellular carcinoma (HCC) using The Cancer Genome Atlas (TCGA) dataset and bioinformatics analysis.
Methods: RNA sequencing and clinical data of HCC patients from TCGA were used for prognostic association assessment by univariate Cox analysis. A prognostic signature was built using stepwise multivariable Cox analysis, and a comprehensive analysis was performed to evaluate its prognostic value.
The aim of the present study was to identify diagnostic and prognostic values of minichromosome maintenance (MCM) gene expression in patients with hepatocellular carcinoma (HCC). : The biological function of the MCM genes were investigated by bioinformatics analysis. The diagnostic and prognostic values of the MCM genes were investigated by using the data of HCC patients from the GSE14520 and The Cancer Genome Atlas (TCGA) databases.
View Article and Find Full Text PDFObjective: To compare the effectiveness of flexible fixation and rigid fixation in the treatment of ankle pronation-external rotation fractures with distal tibiofibular syndesmosis.
Methods: A retrospective analysis was made on the clinical data of 50 patients with ankle pronation-external rotation fractures and distal tibiofibular syndesmosis treated between January 2013 and December 2015. Suture-button fixation was used in 23 patients (flexible fixation group) and cortical screw fixation in 27 patients (rigid fixation group).