NHR-80 senses the mitochondrial UPR to rewire citrate metabolism for lipid accumulation in Caenorhabditis elegans.

Mitochondria are known as the powerhouse of the cell. Dysfunction of mitochondria homeostasis induces the mitochondrial unfolded protein response (UPR), altering cellular metabolism. How cells sense the UPR to rewire metabolism is largely unknown.

Sesquiterpenyl Epoxy-Cyclohexenoids and their Signaling Functions in Nematode-Trapping Fungus .

In this study, we purified three new sesquiterpenyl epoxy-cyclohexenoid (SEC) analogues, arthrobotrisin D () and its two derivatives, from nematode-trapping fungus . Our results revealed that arthrobotrisin type SEC metabolites could be detected in all the test fungal strains from geographically distinct regions grown on different nutrient media, indicative of unique diagnostic character as chemical indicators for . The time course designs over short-term intervals of the fungus under direct contact and indirect contact with living or dead nematodes revealed that arthrobotrisin B and D ( and ) displayed significant relationships (positive or negative correlation) with fungal saprophytic and pathogenic stages during a nematode predation event.

Morphology regulatory metabolites from Arthrobotrys oligospora.

Novel autoregulatory metabolites, arthrosporols A-C (1-3), involved in regulating the morphological switch in fungi, were purified and characterized from the carnivorous fungus Arthrobotrys oligospora. These compounds possess a novel hybrid carbon skeleton consisting of an epoxy-cyclohexenol combined with a rare monocyclic sesquiterpenol substructure. This is the first report of a monocyclic sesquiterpenol of this type of fungal origin.

Isolation of talathermophilins from the thermophilic fungus Talaromyces thermophilus YM3-4.

Six indole alkaloids with various levels of prenylation were isolated from the thermophilic fungus Talaromyces thermophilus strain YM3-4. Their structures were identified by NMR and MS spectroscopic analyses. Compounds 1 and 2 are new analogues of the key versatile precursor notoamide E.

Arthrobotrisins A-C, oligosporons from the nematode-trapping fungus Arthrobotrys oligospora.

Arthrobotrys oligospora is a carnivorous fungus that can use mycelia trapping devices to capture their prey. Three novel oligosporons, named arthrobotrisins A-C (1-3), were isolated from A. oligospora and identified by spectroscopic analysis in combination with X-ray diffraction.