Publications by authors named "Jianli Ma"

Article Synopsis
  • Targeted drug delivery systems are utilizing the acidic environment of tumors to improve drug stability and reduce toxicity through modifications like hydroxyl groups.
  • A newly developed "acetal ester bond" offers a highly sensitive and easy-to-synthesize linkage that allows for efficient drug release specifically in acidic conditions while maintaining stability in healthy physiological environments.
  • The acetal ester bond-based paclitaxel conjugate (PTX-COU) demonstrated superior tumor growth inhibition in experiments, suggesting its potential for enhancing targeted drug delivery and minimizing systemic side effects.
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  • - Chronic obstructive pulmonary disease (COPD)-associated expiratory central airway collapse (ECAC) is a benign but often overlooked condition that leads to airway obstruction, and its diagnosis and treatment are complicated due to unclear mechanisms and atypical symptoms.
  • - Bronchoscopy is the best method for diagnosing ECAC, while noninvasive ventilation and temporary airway stents are common treatment options, though their long-term use and effectiveness still require further investigation.
  • - There is a growing need for research, including randomized controlled trials, cost-effectiveness analyses, and guidelines to improve understanding and management of COPD-associated ECAC in patients.
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  • * Results indicate that certain genetic variants associated with susceptibility to cold sores, viral hepatitis, and infectious mononucleosis may lower the risk of developing CRC, while susceptibility to measles and herpes zoster may increase the risk.
  • * This research is significant as it provides new evidence on how genetic susceptibility to various viral infections can influence CRC risk, contributing to a better understanding of its causes.
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Despite breakthroughs of immunotherapy synergistically combined with blockade of vascular endothelial growth factor receptor, several patients with advanced non-small cell lung cancer (NSCLC) experience non-response or followed relapse. Organized lymphoid aggregates, termed tertiary lymphoid structures (TLSs), are found to be associated with improved response to immunotherapy. Here, we explore the landscapes of TLSs in tumour tissues from a real-world retrospective study.

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Objective: This study aimed to investigate the impact of surgical intervention on peripheral blood T lymphocyte subsets and natural killer (NK) cell activity in pediatric patients with obstructive sleep apnea hypopnea syndrome (OSAHS).

Methods: A total of 36 OSAHS children, 32 children with tonsillar hypertrophy, and 30 healthy children were enrolled. Clinical data and polysomnography (PSG) results were collected.

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Background: Radiotherapy (RT) is essential in the treatment of thoracic neoplasms. Immune checkpoint inhibitors targeting programmed cell death protein 1 (PD-1) and programmed death-ligand 1 (PD-L1) have significantly improved the clinical management of non-small cell lung carcinoma (NSCLC).

Objective: This study aimed to investigate the impact of combining anti-PD-1 (αPD-1) immunotherapy with radiotherapy on lung injury.

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Chronic obstructive pulmonary disease (COPD) is a major public health problem. Due to the restriction of expiratory airflow, it is characterized by emphysematous destruction of the lungs. Shortness of breath is one of the main clinical symptoms.

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T-DM1 (Trastuzumab Emtansine) belongs to class of Antibody-Drug Conjugates (ADC), where cytotoxic drugs are conjugated with the antibody Trastuzumab to specifically target HER2-positive cancer cells. Platelets, as vital components of the blood system, intricately influence the immune response to tumors through complex mechanisms. In our study, we examined platelet surface proteins in the plasma of patients before and after T-DM1 treatment, categorizing them based on treatment response.

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Background: Systemic immune-inflammatory biomarkers including systemic immune inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) have been demonstrated to be associated with the risk and severity of various liver diseases. However, studies on their role and clinical significance in metabolic diseases, especially in nonalcoholic fatty liver disease (NAFLD), are limited and results are inconsistent.

Methods: 10821 adults aged 20 years or older were enrolled in this cross-sectional study, sourced from six cycles of the National Health and Nutrition Examination Survey (NHANES).

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Article Synopsis
  • Ductal carcinoma in situ with microinvasion (DCISM) is a complex subtype of breast cancer that poses challenges for accurate diagnosis and prognosis, making it crucial to distinguish it from regular ductal carcinoma in situ (DCIS) for better treatment outcomes.* -
  • Traditional diagnostic methods struggle to identify the presence of myoepithelium in suspicious cancer samples, with no single biomarker proving effective across all cases.* -
  • A new technique using multiphoton microscopy (MPM) allows for rapid and precise diagnosis of DCISM by analyzing fluorescent signals in tissue samples, showing strong agreement with existing myoepithelial staining methods.*
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Tamoxifen (TAM) resistance poses a significant clinical challenge in human breast cancer and exhibits high heterogeneity among different patients. Rg3, an original ginsenoside known to inhibit tumor growth, has shown potential for enhancing TAM sensitivity in breast cancer cells. However, the specific role and underlying mechanisms of Rg3 in this context remain unclear.

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Background: Studies have shown that there is a connection between estrogen receptor (ER) and glucocorticoid receptor (GR), which can impact the epithelial-mesenchymal transition (EMT) process and contribute to endocrine resistance in breast cancer. However, the specific mechanism is unclear. It is crucial to investigate this mechanism further.

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Background: The pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) of breast cancer is closely related to a better prognosis. However, there are no reliable indicators to accurately identify which patients will achieve pCR before surgery, and a model for predicting pCR to NAC is required.

Methods: A total of 269 breast cancer patients in Shandong Cancer Hospital and Liaocheng People's Hospital receiving anthracycline and taxane-based NAC were prospectively enrolled.

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Natural materials, such as locust mandibles and squid beaks, define significant mechanical gradients that have been attributed to the chemical gradients of their specialized structural proteins (SPs). However, the mechanism by which SPs form chemical gradients in these materials remains unknown. In this study, a highly abundant histidine-rich structural protein (MHSP) was identified in the mandible of a migratory locust ().

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Purpose: Larger-than-planned capsulotomies can occur, yet their association with age and eye parameters remains poorly understood. This study aimed to assess capsulotomy enlargement after femtosecond laser treatment in cataract surgery and to explore a possible correlation of capsulotomy enlargement with age and eye parameters.

Methods: This retrospective case series included consecutive patients diagnosed with cataracts between 05/2018 and 11/2019.

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Cancer progression is a dynamic process of continuous evolution, in which genetic diversity and heterogeneity are generated by clonal and subclonal amplification based on random mutations. Traditional cancer treatment strategies have a great challenge, which often leads to treatment failure due to drug resistance. Integrating evolutionary dynamics into treatment regimens may be an effective way to overcome the problem of drug resistance.

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Article Synopsis
  • The study investigates how collagen features in the breast tumor microenvironment impact patient prognosis, using advanced imaging techniques and data analysis.
  • Researchers utilized multiphoton microscopy to identify collagen signatures at the tumor border and developed a scoring system (CSTB score) based on these features.
  • Findings show that the CSTB score is a stronger prognostic indicator compared to traditional clinical factors, highlighting its potential for improving treatment planning in breast cancer patients.
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Some triple-negative breast cancer (TNBC) patients evaluated as Miller-Payne 4 with ypN0 after neoadjuvant chemotherapy (NACT) who have better prognoses should avoid escalation of therapy. We aim to identify these patients by evaluating pretherapeutic spatial distributions of immunophenotypes. Our retrospective study in patients with TNBC assessed as Miller-Payne grade 4/5 with ypN0 showed that Miller-Payne 4 with ypN0 group had poorer 5-year disease-free survival (DFS, 63.

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Background: Although the executive pathways of senescence are known, the underlying control mechanisms are diverse and not fully understood, particularly how cancer cells avoid triggering senescence despite experiencing exacerbated stress conditions within the tumor microenvironment.

Methods: Mass spectrometry (MS)-based proteomic screening was used to identify differentially regulated genes in serum-starved hepatocellular carcinoma cells and RNAi employed to determine knockdown phenotypes of prioritized genes. Thereafter, gene function was investigated using cell proliferation assays (colony-formation, CCK-8, Edu incorporation and cell cycle) together with cellular senescence assays (SA-β-gal, SAHF and SASP).

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  • The study highlights that traditional classifications of tumor necrosis (TN) in invasive breast cancer ignore important spatial differences that could indicate prognosis.
  • Using multiphoton microscopy, the researchers defined four types of TN based on their spatial relationships and developed a TN-score to assess its prognostic value.
  • Results indicated that only high-risk TN was linked to worse 5-year disease-free survival, suggesting that incorporating TN-score into staging could enhance patient stratification in treatment plans.
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The incidence of glycolipid metabolic diseases is extremely high worldwide, which greatly hinders people's life expectancy and patients' quality of life. Oxidative stress (OS) aggravates the development of diseases in glycolipid metabolism. Radical oxygen species (ROS) is a key factor in the signal transduction of OS, which can regulate cell apoptosis and contribute to inflammation.

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  • Sestrins are gene factors that help cells adapt to stress, with Sestrin2 (SESN2) specifically regulating glycolysis in low-glucose situations.
  • In liver cancer cells, glucose removal reduces glycolysis by lowering the enzyme hexokinase 2 (HK2) and increasing SESN2 levels, which destabilizes HK2 mRNA.
  • SESN2 competes with a protein (IGF2BP3) for binding to HK2 mRNA, leading to lower HK2 levels that reduce glucose uptake, inhibiting cancer cell growth and protecting against cell death from glucose starvation.
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Background: Lung adenocarcinoma (LUAD) is the most common type of non-small cell lung cancer (NSCLC) with poor survival in advanced stage. Nowadays the rate of nonsmoking patients has dramatically increased and may be associated with the presence of driver mutations. Better understanding of the mutation profile data of nonsmoking LUAD patients are critical to predict survival and provide greater benefits to more patients.

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Radiotherapy has shown measurable efficacy in breast cancer (BC). Elucidating the mechanisms and developing effective strategies against resistance, which is a major challenge, is crucial. Mitochondria, which regulate homeostasis of the redox environment, have emerged as a radiotherapeutic target.

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Objective: To predict and determine the mechanism through which Tiao-Bu-Fei-Shen (TBFS) formula improves glucocorticoid resistance in chronic obstructive pulmonary disease (COPD), using network pharmacology, molecular docking technology, and studies.

Methods: The main active components and associated targets of TBFS were screened using the systems pharmacology database of traditional Chinese medicine database (TCMSP). The main COPD targets were retrieved from the Human Gene (GeneCards) and DrugBank databases.

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