Activation of SIRT1 by Hydroxysafflor Yellow A Attenuates Chronic Unpredictable Mild Stress-Induced Microglia Activation and Iron Death in Depressed Rats.

Background: Hydroxysafflor yellow A (HSYA), the main active ingredient in safflower, possesses antioxidant and anti-inflammatory activities. We confirmed in our previous study that HSYA exerts antidepressant effects, but further investigation is needed to uncover the exact mechanism. Herein, we aimed to explore the antidepressant effects of HSYA based on microglial activation and ferroptosis studies.

The clinical and neuroradiological features of hypertrophic olivary degeneration following brainstem stroke.

Objectives: Hypertrophic olivary degeneration (HOD), a rare type of trans-synaptic degeneration of the central nervous system (CNS) caused by disruption of the dentato-rubro-olivary pathway (DROP), is mainly described in the form of case reports. Our aim in this study is to summarize the clinical and imaging characteristics of patients with HOD following brainstem stroke.

Methods: A retrospective analysis was performed for all patients who were selected from electronic case databases between October 2019 and January 2024 in the Jiangxi Provincial People's Hospital and the Xinyu People's Hospital.

Baicalein sensitizes triple negative breast cancer MDA-MB-231 cells to doxorubicin via autophagy-mediated down-regulation of CDK1.

Triple negative breast cancer (TNBC) is a kind of refractory cancer with poor response to conventional chemotherapy. Recently, the combination of baicalein and doxorubicin was reported to exert a synergistic antitumor effect on breast cancer. However, the underlying mechanism how baicalein sensitizes breast cancer cells to doxorubicin remains to be elucidated.

Atorvastatin Pretreatment Attenuates Ischemic Brain Edema by Suppressing Aquaporin 4.

Background: Cerebral edema, a serious complication of acute cerebral infarction, has a crucial impact on morbidity and mortality in the early stage of cerebral infarction. And aquaporin 4 (AQP4), a bidirectional water transporting protein, plays a pivotal role in edema formation. At experimental model, it has proven that atorvastatin could exert pleiotropic neuroprotection on acute cerebral infarction independent of its cholesterol-lowering action.

Rapidly progressive cognitive impairment caused by intracranial dural arteriovenous fistulas (DAVFs): a case report.

Intracranial dural arteriovenous fistulas (DAVFs), constituting approximately 10 to15% of intracranial vascular malformations, are anomalous direct connections between dural arteries and venous sinuses, meningeal veins, or cortical veins; the arterial feeders are various, usually fed by branches of internal carotid, external carotid, or vertebral artery (Santillan et al. CNN 115(3):241-251, 2013; Holoekamp et al. JN 124(6):1752-65, 2016; Terada T et al.