Publications by Jiankang Zhong

Publications by authors named "Jiankang Zhong"

J Am Chem Soc

August 2024

* Formation of the knot was aided by Co(II) metals, which helped create a complex structure that was locked in place through oxidation and a chemical process called ring-closing olefin metathesis.
* After removing the metal ions and modifying the structure, researchers found that the knot's design influenced how light interacts with it more than the individual chiral centers did.

J Am Chem Soc

September 2019

Researchers developed a method for synthesizing trefoil knots with a single topological handedness using trimeric circular helicates, achieving yields of up to 90% over two steps.
The synthesis involves using metal ion templates (zinc(II) for imines and cobalt(III) for amides) that influence the coordination stereochemistry, resulting in knots that are enantiomerically pure in their topology.
Characterization techniques like NMR spectroscopy, mass spectrometry, and X-ray crystallography confirmed the structure and chirality of the knots, revealing that the knots' topological handedness primarily affects their optical properties, as assessed by circular dichroism.

J Am Chem Soc

April 2018

A molecular trefoil knot was successfully synthesized in two steps with a high yield of 90%.
The process involved self-assembling a 12-component trimeric circular zinc helicate, which served as an intermediate.
The final trefoil knot was characterized using techniques like NMR spectroscopy, mass spectrometry, and X-ray crystallography.

Angew Chem Int Ed Engl

December 2014

Zanamivir, laninamivir, and CS-8958 are neuraminidase inhibitors used for treating influenza, and this text introduces a new method for synthesizing these compounds.
The proposed organocatalytic process involves only 13 steps, specifically utilizing D-araboascorbic acid as a starting material.
The synthesis is scalable, demonstrated by the successful production of over 3.5 grams of zanamivir.