Low serum Metrnl levels are associated with increased risk of sarcopenia in the older adults.

Purpose: Sarcopenia is a geriatric syndrome characterized by progressive loss of muscle mass and function. Meteorin-like (Metrnl) is a secretory protein that has protective effects on skeletal muscle injury. However, the association of Metrnl level with sarcopenia remains unclear.

LncRNA lnc-SPRR2G-2 contributes to keratinocyte hyperproliferation and inflammation in psoriasis by activating the STAT3 pathway and downregulating KHSRP.

Psoriasis is a chronic inflammatory disease characterized by increased keratinocyte proliferation and local inflammation. Long noncoding RNAs (lncRNAs) play important regulatory roles in many immune-mediated diseases, including psoriasis. In this study, we aimed to investigate the role and mechanism of lnc-SPRR2G-2 (SPRR2G) in M5-treated psoriatic keratinocytes.

Peripapillary hyperreflective ovoid mass-like structures with cystoid macular edema: a case report.

Background: Peripapillary hyperreflective ovoid mass-like structures (PHOMS) are newly characterized lesions wedged around the optic discs, which used to be misdiagnosed. Better understanding and identifying PHOMS are important for monitoring the condition of optic nerve.

Case Presentation: A young female presented to the ophthalmic clinic with blurred vision of both eyes.

An innovative approach for assessing coronary artery lesions: Fusion of wrist pulse and photoplethysmography using a multi-sensor pulse diagnostic device.

Coronary heart disease (CHD) is a leading cause of mortality globally and poses a significant threat to public health. Coronary angiography (CAG) is a gold standard for the clinical diagnosis of CHD, but its invasiveness restricts its widespread application. In this study, we utilized a pulse diagnostic device equipped with pressure and photoelectric sensors to synchronously and non-invasively capture wrist pressure pulse waves and fingertip photoplethysmography (FPPG) of patients undergoing CAG.

The influence of shift work: A bibliometric analysis of research progress and frontiers on health effects.

Shift work has been found to disrupt the circadian system, leading to negative health effects. The objective of this study was to assess the progress and frontiers in research on the health-related influence of shift work. The study analyzed 3,696 data points from Web of Science, using the bibliometric software CiteSpace to visualize and analyze the field.

Transcriptional patterns of human retinal pigment epithelial cells under protracted high glucose.

Background: The retinal pigment epithelium (RPE) is essential for retinal homeostasis. Comprehensively exploring the transcriptional patterns of diabetic human RPE promotes the understanding of diabetic retinopathy (DR).

Methods And Results: A total of 4125 differentially expressed genes (DEGs) were screened out from the human primary RPE cells subjected to prolonged high glucose (HG).

High Expression of miR-6785-5p in the Serum Exosomes of Psoriasis Patients Alleviates Psoriasis-Like Skin Damage by Interfering with the MNK2/p-eIF4E Axis in Keratinocytes.

Psoriasis is a chronic inflammatory skin disease characterized by abnormal keratinocyte proliferation and inflammation. MiRNAs and serum exosomes participate in the pathogenesis of many diseases. The objective of this study is to explore the function of miR-6785-5p in psoriatic keratinocytes and its upstream and downstream mechanisms.

LPCAT1 Facilitates Keratinocyte Hyperproliferation and Skin Inflammation in Psoriasis by Regulating GLUT3.

Psoriasis is a chronic and relapsing inflammatory skin disorder characterized by keratinocyte hyperproliferation and immune cell infiltration. LPCAT1 has been identified as a cancer promoter in cutaneous squamous cell carcinoma by us, yet its role in psoriasis remains elusive. In this study, we report that LPCAT1 is highly expressed in psoriatic skin lesions.

Tear Film Stability Affects Visual Acuity After Implantations of Monofocal and Multifocal Intraocular Lenses: An Evaluation by Objective Scatter Index.

Purpose: To assess the impact of tear film on postoperative visual acuity after cataract surgery to implant an intraocular lens (IOL).

Methods: Tear break-up time (TBUT), Schirmer I test, objective scatter index (OSI), and uncorrected distance visual acuity (UCDVA), intermediate visual acuity (UCIVA), and near visual acuity (UCNVA) were collected 6 months after cataract surgery.

Results: Fifteen eyes with monofocal (Mo-) IOLs and 15 eyes with multifocal (Mu-) IOLs from 30 subjects were included.

Uncertainty quantification of microcirculatory characteristic parameters for recognition of cardiovascular diseases.

Background: Cardiovascular disease is one of the leading causes of death worldwide. However, according to studies, 90% of cardiovascular diseases can be prevented. Cardiovascular function parameters are an important basis for the diagnosis of cardiovascular diseases.

Skeleton-Based Fall Detection with Multiple Inertial Sensors Using Spatial-Temporal Graph Convolutional Networks.

The application of wearable devices for fall detection has been the focus of much research over the past few years. One of the most common problems in established fall detection systems is the large number of false positives in the recognition schemes. In this paper, to make full use of the dependence between human joints and improve the accuracy and reliability of fall detection, a fall-recognition method based on the skeleton and spatial-temporal graph convolutional networks (ST-GCN) was proposed, using the human motion data of body joints acquired by inertial measurement units (IMUs).

Mapping of quantitative trait locus reveals gene encoding xylanase inhibitor as the candidate gene for bruchid ( spp.) resistance in pea ( L.).

Pea ( L.) is an important legume crop for both food and feed. Bruchids ( spp.

Tongue crack recognition using segmentation based deep learning.

Tongue cracks refer to fissures with different depth and shapes on the tongue's surface, which can characterize the pathological characteristics of spleen and stomach. Tongue cracks are of great significance to the objective study of tongue diagnosis. However, tongue cracks are small and complex, existing methods are difficult to extract them effectively.

Tongue Image Texture Classification Based on Image Inpainting and Convolutional Neural Network.

Tongue texture analysis is of importance to inspection diagnosis in traditional Chinese medicine (TCM), which has great application and irreplaceable value. The tough and tender classification for tongue image relies mainly on image texture of tongue body. However, texture discontinuity adversely affects the classification of the tough and tender tongue classification.

Automated Segmentation of the Systolic and Diastolic Phases in Wrist Pulse Signal Using Long Short-Term Memory Network.

Purpose: Single-period segmentation is one of the important steps in time-domain analysis of pulse signals, which is the basis of time-domain feature extraction. The existing single-period segmentation methods have the disadvantages of generalization, reliability, and robustness.

Method: This paper proposed a period segmentation method of pulse signals based on long short-term memory (LSTM) network.

Downregulation of miRNA miR-1305 and upregulation of miRNA miR-6785-5p may be associated with psoriasis.

The role of serum extracellular vesicles (EVs) is less known in psoriasis. To explore the transcriptomic profile of serum EVs and the potential biomarkers in psoriasis. EVs were isolated by differential ultracentrifugation and identified by transmission electron microscope.

KMT2C Induced by FABP5P3 Aggravates Keratinocyte Hyperproliferation and Psoriasiform Skin Inflammation by Upregulating the Transcription of PIK3R3.

The extensive involvement of lysine methyltransferase 2C (KMT2C) in the inflammatory response is well-documented. However, little is known about the role of KMT2C in psoriasis. We identified that KMT2C was significantly upregulated in the epidermis of psoriatic skin lesions and the psoriasiform cell model.

Sodium-Based Cylindrical Plasmonic Waveguides in the Near-Infrared.

Subwavelength optical field confinement and low-loss propagation are of great significance for compact photonic integration. However, the field confinement capability of plasmonic devices is always accompanied by the inherent Ohmic loss. Although recent studies have shown that sodium (Na) exhibits lower loss than noble metals in the near-infrared band, the field confinement ability has not been adequately assessed.

ILF2 Contributes to Hyperproliferation of Keratinocytes and Skin Inflammation in a KLHDC7B-DT-Dependent Manner in Psoriasis.

The extensive involvement of interleukin enhancer binding factor 2 (ILF2) in RNA stability and the inflammatory response is well documented. Aberrant long noncoding RNA (lncRNA) expression contributes to the pathogenesis of psoriasis. However, little is known about the role of ILF2 in psoriasis.

CircOAS3 Regulates Keratinocyte Proliferation and Psoriatic Inflammation by Interacting with Hsc70 via the JNK/STAT3/NF-κB Signaling Pathway.

Psoriasis is a chronic inflammatory disease of the skin with a very complex pathogenesis. Circular RNAs (circRNAs) play important regulatory roles in many diseases, including psoriasis. In this study, we found that circOAS3 expression was significantly upregulated in both psoriatic tissues and M5-induced keratinocytes.

CircEIF5 contributes to hyperproliferation and inflammation of keratinocytes in psoriasis via p-NFκB and p-STAT3 signalling pathway.

Psoriasis is a chronic, immune-mediated skin disease accompanied by hyperproliferation and inflammation of keratinocytes. Circular RNAs (circRNAs) as new players regulating the development of psoriasis have been reported in recent years. However, its mechanism has not yet been fully revealed.

Tai Chi Program to Improve Glucose Control and Quality of Life for the Elderly With Type 2 Diabetes: A Meta-analysis.

Objective: To systematically evaluate the effects of Tai chi for improving elderly patients with type 2 diabetes.

Methods: According to PRISMA checklist, we conducted this standard meta-analysis. The multiple databases like Pubmed, Embase, and Cochrane databases were used to search for the relevant studies, and full-text articles involved in the evaluation of Tai chi in improving elderly patients with type 2 diabetes.

Par3 regulates the asymmetric division of basal stem cells in psoriasis via the Par3/mInsc/LGN signaling axis.

Objective: This research aimed to investigate the mechanism in psoriasis with the involvement of Par3-containing exosomes from macrophages by regulating the asymmetric division of basal stem cells.

Methods: BrdU labeling and double immunofluorescence assays were conducted to detect the proportion of asymmetric division in psoriasis mice. Western blot assay was conducted to examine the expression of Par3/mInsc/LGN signaling pathway-related proteins in psoriasis mice.