Publications by authors named "Jianjun Xu"

A novel noninasive method was developed for determining glucose levels in human exhaled breath and saliva using ion chromatography. This innovative approach involves collecting exhaled breath and saliva samples using a self-designed condensation device and non-stimulative method to ensure minimal participant discomfort. The glucose contents in both exhaled breath condensate (EBC) and saliva were analyzed using ion chromatography, which is highly sensitive and specific.

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Ultraviolet radiation serves as a significant abiotic stressor for numerous organisms, particularly impacting insects in various ways. , a highly destructive pest infesting of the Solanaceae species, was investigated to elucidate its growth, development, and enzymatic defense mechanisms of insects in response to UV exposure. This study investigates the effects of three types of UV radiation on the lifespan, egg laying behavior, and antioxidant enzyme activities of .

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is a holoparasitic weed that extracts water, nutrients, and growth regulators from host plants, leading to significant yield and quality losses. Biocontrol microbial metabolites have been shown to enhance plant resistance against parasitic plants, yet the underlying microbial mechanisms remain poorly understood. In this study, we investigated the role of JTF001 (J1) microbial metabolites in recruiting beneficial microbes to the tomato rhizosphere and promoting the establishment of a disease-suppressive microbiome.

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Cognitive frailty is increasingly prevalent among elderly patients, heightening the risks of dementia, disability, and mortality. This demographic also faces a rising incidence of lung cancer, and cognitive frailty complicates rehabilitation efforts. Research on cognitive frailty in elderly lung cancer patients is still emerging.

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Article Synopsis
  • The study investigates pyroptosis, a form of programmed cell death, in the context of status epilepticus (SE), a condition marked by prolonged seizures, and how it relates to neurodegeneration.
  • Researchers induced SE in mice using pilocarpine and found increased levels of inflammatory markers and TRPM7 expression, identifying TRPM7 as a key player in neuronal damage and hyperexcitability.
  • The findings suggest that targeting TRPM7 and NLRP3 could be a potential treatment strategy for SE, as inhibiting these pathways alleviated neuronal hyperexcitability and pyroptosis.
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Background: The incidence and mortality rates of cancer are the highest globally. Developing novel methodologies that precisely, safely, and economically differentiate between benign and malignant lung conditions holds immense clinical importance. This research seeks to construct a predictive model utilizing a combination of diverse biomarkers to effectively discriminate between benign and malignant lung diseases.

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In recent years, twin pregnancies have become increasingly common. The aim of our study was to analyze the exposure to risk factors for postpartum pulmonary edema in twin pregnancies. We get all our data from the "DATADRYAD" database, which is available directly.

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Considering the case where the response variable is a categorical variable and the predictor is a random function, two novel functional sufficient dimensional reduction (FSDR) methods are proposed based on mutual information and square loss mutual information. Compared to the classical FSDR methods, such as functional sliced inverse regression and functional sliced average variance estimation, the proposed methods are appealing because they are capable of estimating multiple effective dimension reduction directions in the case of a relatively small number of categories, especially for the binary response. Moreover, the proposed methods do not require the restrictive linear conditional mean assumption and the constant covariance assumption.

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Accident Tolerant Fuel (ATF) is a next-generation fuel technology developed to enhance the fundamental safety of light water reactors. Compared to existing standard fuel technologies, ATF technology can provide the same or better performance during normal operation, transient conditions, and accident scenarios of nuclear power plants, enhancing the ability of fuel elements to withstand severe accidents while reducing the cost of generating electricity over the licensed life of the plants. This paper introduces the definition, characteristics and thermal-hydraulic research objectives of ATF technology, systematically reviews the thermal-hydraulic research results of different ATF technologies in various aspects from the perspectives of near-term concepts (UO-based composite fuels, coated Zr-based claddings, FeCrAl claddings) and long-term concepts (high-uranium-density UN fuels, FCM fuels, extruded metal fuels, SiC/SiC claddings), respectively.

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  • A new prognostic nomogram for predicting outcomes in elderly patients (80+) with early-stage non-small cell lung cancer (NSCLC) has been developed and shows promise for clinical use.
  • The model was created using data from over 7,000 patients in the SEER database, identifying 10 key prognostic factors that influence cancer-specific survival.
  • The nomogram outperformed the traditional AJCC TNM staging system in predicting survival rates, demonstrating its potential as a valuable tool for oncologists.
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Insect life processes and reproductive behaviors are significantly affected by extremely high temperatures. This study focused on , which poses a severe threat to tomato cultivars. The effects of intense heat stress on the growth, development, oviposition, and longevity of were investigated.

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Targeted delivery of glutamine metabolism inhibitors holds promise for cholangiocarcinoma therapy, yet effective delivery vehicles remain a challenge. This study reports the development of a biomimetic nanosystem, termed R-CM@MSN@BC, integrating mesoporous organosilicon nanoparticles with reactive oxygen species-responsive diselenide bonds for controlled release of the glutamine metabolism inhibitor bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl) ethyl sulfide (BPTES) and the photosensitizer Ce6. Erythrocyte membrane coating, engineered with Arg-Gly-Asp (RGD) peptides, not only enhanced biocompatibility but also improved tumor targeting and tissue penetration.

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Pedunculoside, a triterpene saponin derived from various species, holds potential as a treatment for cardiovascular diseases. However, its clinical application is hindered by poor bioavailability, rapid elimination, and extensive intestinal metabolism to rotundic acid. To address these issues, a water-soluble inclusion complex of pedunculoside, namely, the beta-CD polymer inclusion complex of pedunculoside (pedunculoside-βCDP), was prepared in this study, and a comparative in vitro stability and pharmacokinetic behavior study was performed between pedunculoside and pedunculoside-βCDP.

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Polystyrene is a staple plastic in the packaging and insulation market. Despite its good recyclability, the willingness of PS recycling remains low, largely due to the high recycling cost and limited profitability. This review examines the research progresses, gaps, and challenges in areas that affect the recycling costs, including but not limited to logistics, packaging design, and policymaking.

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  • Steatotic donor livers, which have a lot of fat, are being used more in liver transplants, but they can get hurt more easily during surgery.
  • Scientists studied how these livers get damaged and found that a protein called caspase-8 is involved in causing cell death, but it doesn't help with inflammation.
  • They discovered that another protein, RIPK1, makes the damage worse by causing both cell death and inflammation, and a third protein, ZBP1, helps activate RIPK1 during the injury, so targeting these proteins could help protect these fat-filled livers during transplants.
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  • Deep transfer learning is utilized for enhancing models in cross-domain fault diagnosis of rolling bearings, where traditional methods struggle with differing data distributions.
  • The proposed deep reconstruction transfer convolutional neural network (DRTCNN) leverages unsupervised training and a deep reconstruction convolutional autoencoder to extract features that are consistent across domains.
  • A new subdomain alignment loss function and a label smoothing algorithm are introduced to improve classification accuracy and model robustness by addressing issues related to data distribution and label reliability.
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A non-invasive condensation collection-ion chromatography method was established for the determination of organic acids and anions including lactic acid, formic acid, acetic acid, pyruvic acid, chloride, nitrate, nitrite, and sulfate in the exhaled breath of humans. The breath exhaled was condensed and collected using a home-made exhaled breath condensation equipment. This equipment included a disposable mouthpiece as a blow-off port, one-way valve and flow meter, cold trap, disposable condensate collection tube placed in the cold trap, and gas outlet.

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Background: As lung squamous cell carcinoma (LUSC) patients are at increased risk of developing a second primary cancer, this complicates the patient's condition and thus makes prognostic assessment more difficult, posing a significant prognostic challenge for clinicians. Our goal was to assess the prognosis of LUSC patients with a second primary tumor, and provide insights into appropriate therapy and monitoring strategies.

Methods: Data was obtained for LUSC patients from the Surveillance, Epidemiology, and End Results (SEER) database.

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Photodynamic therapy (PDT) is a minimally invasive and controllable local cancer treatment for cholangiocarcinoma (CCA). However, the efficacy of PDT is hindered by intratumoral hypoxia and the presence of an antioxidant microenvironment. To address these limitations, combining PDT with gas therapy may be a promising strategy to enhance tumor oxygenation.

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There are numerous causes of abdominal aortic calcification (AAC), among which the relationship between serum uric acid and AAC still needs to be investigated further. The aim of this research was to ascertain whether serum uric acid is correlated with AAC. Our study included 3007 participants.

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Background: Numerous studies have demonstrated that fine particulate matter (PM) is adversely associated with COVID-19 incidence. However, few studies have explored the spatiotemporal heterogeneity in this association, which is critical for developing cost-effective pollution-related policies for a specific location and epidemic stage, as well as, understanding the temporal change of association between PM and an emerging infectious disease like COVID-19.

Methods: The outcome was state-level daily COVID-19 cases in 49 native United States between April 1, 2020 and December 31, 2021.

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Laparoscopic total adrenalectomy has become the standard treatment for adrenal mass. Meanwhile, there has been a growing trend toward laparoscopic adrenal-sparing surgery worldwide to avoid the risk and potential complications of adrenal insufficiency. The objectives of this study were to describe a retroperitoneoscopic adrenal tumor enucleation technique, to assess the clinical outcomes of this technique in the treatment of 20-40 mm nonsecreting adrenal tumor (NAT) with low potential of malignancy, and to provide a feasible choice for patients who have preference on resection.

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  • Heart failure is a serious medical condition linked to abnormal atrial activity, increased stroke risk, and atrial remodelling due to oxidative stress; HACE1, a regulatory gene, may help protect the heart.
  • Researchers analyzed clinical data from heart failure patients and used mouse models to investigate gene expression and cardiac function through various assays.
  • The study found reduced HACE1 in heart failure cases linked to increased fibrosis; its up-regulation improved heart function and reduced oxidative stress, suggesting HACE1 as a potential therapeutic target by enhancing NRF2 activity.
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Background: Myocardial ischemia-reperfusion injury (MIRI) is one of the main reasons for poor prognosis in patients with ischemic cardiomyopathy (ICM). To date, the mechanism remains unknown. As members of the silent information regulator 2 (SIR2) family, both SIRT1 and SIRT3 have been shown to play critical roles in protecting cardiomyocytes against MIRI, but their specific protective mechanism, their interact between the two and their relationship with ferroptosis are still unclear.

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An outbreak of stem rot in eggplants was observed in Heshuo County, Xinjiang, during winter 2021-2022 in about 12-35% of the eggplants in the region (about 40 hm). The infected tissues yielded a total of four bacterial strains, which were subsequently subjected to physiological and biochemical assays as well as molecular identification. Based on these analyses, the pathogen was identified as subsp.

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