Association of neutrophil percentage to albumin ratio with gallstones: a cross-sectional study from the United States NHANES.

Background And Objective: The neutrophil percentage to albumin ratio (NPAR) is an emerging, costimulatory indicator of inflammation that is associated with a variety of diseases, such as non-alcoholic fatty liver disease, liver fibrosis, stroke, and cardiovascular disease. However, the relationship between NPAR and gallstones (GS) has not yet been explored. Therefore, this study aimed to evaluate the association of the NPAR with the odds of GS and the age of patients at the time of their first GS surgery.

The role of artificial intelligence in drug screening, drug design, and clinical trials.

The role of computational tools in drug discovery and development is becoming increasingly important due to the rapid development of computing power and advancements in computational chemistry and biology, improving research efficiency and reducing the costs and potential risks of preclinical and clinical trials. Machine learning, especially deep learning, a subfield of artificial intelligence (AI), has demonstrated significant advantages in drug discovery and development, including high-throughput and virtual screening, design of drug molecules, and solving difficult organic syntheses. This review summarizes AI technologies used in drug discovery and development, including their roles in drug screening, design, and solving the challenges of clinical trials.

Self-Selective (220) Directional Grown Copper Current Collector Design for Cycling-Stable Anode-Less Lithium Metal Batteries.

Anode-less lithium metal batteries (ALLMB) are promising candidates for energy storage applications owing to high-energy-density and safety characteristics. However, the unstable solid electrolyte interphase (SEI) formed on anode copper current collector (CuCC) leads to poor reversibility of uneven lithium deposition/stripping. Though the well-known knowledge of lithium salt-derived inorganic-rich SEI (iSEI) benefiting uniform lithium deposition, how to design a lithium salt-philic CuCC with undiscovered salt-philic facet that favors lithium salt adsorption and catalyzing salt decomposition into iSEI, remains unexplored yet.

Elucidating the linagliptin and fibroblast activation protein binding mechanism through molecular dynamics and binding free energy analysis.

Fibroblast activation protein (FAP) is highly expressed in solid tumors and may be a potential diagnostic and therapeutic target in solid cancers. Linagliptin inhibits FAP; however, the interaction mechanism between linagliptin and FAP remains unclear. In this study, the binding free energy for linagliptin with human FAP was estimated at -13.

Stanniocalcin-1 in tumor immunity: acts via macrophages.

Tumor immune escape has become a research hotspot in the field of cancer immunotherapy. Tumor-associated macrophages (TAMs) are the key component of tumor microenvironment, which play a pivotal role in tumor immune escape by regulating the immunity checkpoints, inhibiting the activity of T lymphocytes and natural killer (NK) cells, and modulating proportion of different T cells. Stanniocalcin-1(STC1)is ubiquitously expressed in human body, which is proven to involve with tumor progression and clinical prognosis.

The role of DDR1 in cancer and the progress of its selective inhibitors.

Discoidin domain receptor 1 (DDR1) is a member of the receptor tyrosine kinase superfamily, which mainly activates downstream signaling pathways through binding to collagen. The abnormal expression of DDR1 is closely related to the occurrence and development of various tumors, and it is one of the potential targets for molecular targeted therapy. At present, specific antibodies and selective small molecule inhibitors against DDR1 have been approved for Phase I clinical trials.

Integrative Bioinformatics Analysis and Experimental Study of NLRP12 Reveal Its Prognostic Value and Potential Functions in Ovarian Cancer.

NLRP12 plays a significant role in cellular functional behavior and immune homeostasis, influencing inflammation, tumorigenesis, and prognosis. This study aimed to explore its specific effects on the tumor microenvironment (TME) and its contribution to heterogeneity in ovarian cancer (OV) through bioinformatics analysis and experimental verification. Utilizing various bioinformatics databases and clinical specimens, we investigated NLRP12 expression and its relationship with OV prognosis and immune infiltration.

Wnt/β-Catenin Pathway-Mediated Overexpression Facilitates the Resistance of Non-Small Cell Lung Cancer Cells to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors.

Background: Epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) is considered highly effective treatment for advanced non-small cell lung cancer (NSCLC), who often develop drug resistance after 10 months of treatment. Herein, the aim was to unravel the mechanism behind the resistance to icotinib in NSCLC.

Methods: Establishment of icotinib-resistant PC-9 cells (PC-9R) was achieved through repeated exposure to increasing concentrations of icotinib for more than 12 months.

The breakthrough of oxide pathway mechanism in stability and scaling relationship for water oxidation.

An in-depth understanding of electrocatalytic mechanisms is essential for advancing electrocatalysts for the oxygen evolution reaction (OER). The emerging oxide pathway mechanism (OPM) streamlines direct O-O radical coupling, circumventing the formation of oxygen vacancy defects featured in the lattice oxygen mechanism (LOM) and bypassing additional reaction intermediates (*OOH) inherent to the adsorbate evolution mechanism (AEM). With only *O and *OH as intermediates, OPM-driven electrocatalysts stand out for their ability to disrupt traditional scaling relationships while ensuring stability.

Application of polyamide 56 nanofiber membrane loaded with coffee grounds carbon dots in Fe detection.

One novel nanofiber membrane was fabricated which could detect Fe with the help of either fluorescence spectrometer or smartphone. Coffee grounds carbon dots (CCDs) were prepared by the solvent-thermal method, followed by the fabrication of CCDs/polyamide 56 (PA56) composite nanofiber membrane through electrospinning process. The 4 % CCDs/PA56 composite nanofiber membrane (FNM4) maintained good fluorescence performance (λ = 554 nm, λ = 470 nm) even after 5-runs quenching-recovery cycles.

Hybrid plug-and-play CT image restoration using nonconvex low-rank group sparsity and deep denoiser priors.

. Low-dose computed tomography (LDCT) is an imaging technique that can effectively help patients reduce radiation dose, which has attracted increasing interest from researchers in the field of medical imaging. Nevertheless, LDCT imaging is often affected by a large amount of noise, making it difficult to clearly display subtle abnormalities or lesions.

A smartphone-integrated bimetallic ratiometric fluorescent probe for specific visual detection of tetracycline antibiotics in food samples and latent fingerprinting.

Designing and preparing highly sensitive and accurate fluorescent chemosensors for monitoring tetracycline antibiotics remains a challenge. Herein, a fluorescent chemosensor based on lanthanide metal-organic frameworks (Ln-MOFs) is proposed to realize high-precision monitoring by adjusting the ratio of lanthanide ions. Ln-MOFs with good aqueous stability were prepared by a solvothermal method using Eu, Tb and the ligand 4,4',4″-s-triazine-2,4,6-triyltribenzoic acid (HTATB) in DMF/NMP/HO.

Co-application of Validamycin A and dsRNAs targeting trehalase genes conferred enhanced insecticidal activity against Laodelphax striatellus.

The small brown planthopper (SBPH), Laodelphax striatellus, poses a significant threat to rice crops, necessitating innovative pest control strategies. This study evaluated the potential of validamycin A (Val A) and RNA interference (RNAi) targeting trehalase genes (LsTre1 and LsTre2) in controlling SBPH. Our results demonstrated that Val A treatment of rice seedlings led to a dose-dependent mortality of SBPH.

Knockdown of TcGluCl leads to the premature pupation of Tribolium castaneum larvae possibly by influencing the calcium-mediating hormone homeostasis.

The glutamate-gated chloride channels (GluCls) are widely existed in the neural and nonneural tissues of invertebrate. In addition to play important roles in signal transduction, the GluCls also showed multiple physiological functions in insects such as participate in the juvenile hormone synthesis. In the present study, the potential roles of TcGluCl in growth and development of the red flour beetle Tribolium castaneum were explored.

Efficacy of problem-solving therapy in treating late-life depression with potential cognitive impairment: a systematic review and meta-analysis.

Introduction: Late-life depression (LLD) is a global public health issue, often accompanied by cognitive impairments that can exacerbate the severity of depression and impair social functioning. Despite being a well-established treatment for LLD, the suitability of problem-solving therapy (PST) for individuals with LLD and varying degrees of cognitive impairments warrants further investigation. This paper presents the protocol for a systematic review and meta-analysis of randomised controlled trials (RCTs) aimed at evaluating the effectiveness and acceptability of PST for this specific demographic.

Deep plug-and-play MRI reconstruction based on multiple complementary priors.

Magnetic resonance imaging (MRI) is widely used in clinical diagnosis as a safe, non-invasive, high-resolution medical imaging technology, but long scanning time has been a major challenge for this technology. The undersampling reconstruction method has become an important technical means to accelerate MRI by reducing the data sampling rate while maintaining high-quality imaging. However, traditional undersampling reconstruction techniques such as compressed sensing mainly rely on relatively single sparse or low-rank prior information to reconstruct the image, which has limitations in capturing the comprehensive features of images, resulting in the insufficient performance of the reconstructed image in terms of details and key information.

Higher triglyceride glucose-waist height ratio index is associated with higher prevalence of gallstone: a population-based study.

Background: The aim of this study is to evaluate the association between triglyceride glucose-waist height ratio (TyG-WHtR) index and the prevalence of gallstone disease (GSD), alongside the age at first gallstone surgery among adult populations within the United States.

Methods: We screened participants using the National Health and Nutrition Examination Survey (NHANES). Logistic regression analysis, generalized additive modeling, smoothed curve fitting, and subgroup analysis were employed to assess the association between the TyG-WHtR index, prevalence of GSD, and the age at initial gallstone surgical intervention.

Bcwf regulates the white petal color in pak choi [Brassica campestris (syn. Brassica rapa) ssp. chinensis].

Flower color is important in determining the ornamental value of Brassica species. However, our knowledge about the regulation of flower color in pak choi [Brassica campestris (syn. Brassica rapa) ssp.

The anti-inflammatory effect of arsenic trioxide effectively mitigates the pathogenic process in local chickens with avian leukosis.

Arsenic trioxide (ATO) is a classic first-line treatment for acute promyelocytic leukemia (APL). An increasing number of studies regarding the use of ATO in tumor treatment have shown consistently remarkable results. In this study, subgroup J avian leukosis virus (ALV-J) was used as a model virus, and different doses of ATO were used to treat ALV-J-positive chickens.