The PKM2/HIF-1α Axis is Involved in the Pathogenesis of Endometriosis via TGF-β1 under Endometrial Polyps.

Background: Endometriosis patients exhibit a cancer-like glycolytic phenotype. The pyruvate kinase M2 (PKM2)/hypoxia-inducible factor-1 alpha (HIF-1α) axis plays important roles in glycolysis-related diseases, but its role in patients with endometrial polyps (EPs) combined with endometriosis has not been validated.

Methods: EP samples were collected from patients with and without endometriosis.

Association of birth weight, childhood obesity, and age at menarche with the risk of ovarian dysfunction: A mendelian randomization study.

Background: Observational studies have revealed associations between birth weight, childhood obesity, age at menarche, and ovarian dysfunction. However, these studies are susceptible to unavoidable confounding factors, leading to ongoing debates regarding their conclusions and making causal relationships challenging to infer. In light of these challenges, Mendelian randomization was employed in this study to investigate the causal relationships between birth weight, childhood obesity, age at menarche, and ovarian dysfunction.

Effects of continuous monoculture on rhizosphere soil nutrients, growth, physiological characteristics, hormone metabolome of and their interaction analysis.

Continuous planting is unavoidable in agricultural production, but continuous planting affects plant growth and physiological characteristics. In this study, we analyzed rhizosphere soil nutrients, physiological characteristics, hormone metabolome changes and their interactions of () with the increase of continuous planting number. The results found that root was significantly inhibited, the plant height was dwarfed and the biomass was significantly reduced as continuous planting number increased.

Effect of continuous planting on rhizosphere soil physicochemical indexes, microbial functional diversity and metabolites.

Continuous planting has a severe impact on the growth of . In this study, the effects of three different long-term monocultures (one, two and three replanting) on the physicochemical indexes, microbial functional diversity, and soil metabolomics were analyzed in rhizosphere soil. The results showed that rhizosphere soil organic matter content, cation exchange capacity, total and available nitrogen, total and available phosphorus, and total and available potassium contents significantly decreased with the increasing number of continuous plantings.

Metagenomics-based exploration of key soil microorganisms contributing to continuously planted growth inhibition and their interactions with soil nutrient transformation.

() is an economically important forest tree species, often cultivated in continuous monoculture as a coastal protection forest. Continuous planting has gradually affected growth and severely restricted the sustainable development of the industry. In this study, we analyzed the effects of continuous planting on growth and explored the rhizosphere soil microecological mechanism from a metagenomic perspective.

Prognostic significance of prognostic nutritional index and systemic immune-inflammation index in patients after curative breast cancer resection: a retrospective cohort study.

Background: Nutritional status and inflammation are closely associated with poor outcome in malignant tumors. However, the prognostic impact of postoperative in these variables on breast cancer (BC) remains inconclusive. We aimed to determine whether prognostic nutritional index (PNI), systemic immune-inflammation index (SII), neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) affect two long-term outcomes among patients after curative resection of BC.

The integrase of genomic island GI mediates the mobilization of GI and IS-related element CR2- unit through site-specific recombination.

In the worldwide health threat posed by antibiotic-resistant bacterial pathogens, mobile genetic elements (MGEs) play a critical role in favoring the dissemination of resistance genes. Among them, the genomic island GI and the IS-related element CR2 unit are believed to participate in this dissemination. However, the mobility of the two elements has not yet been demonstrated.

Transcriptome analysis provides insights into copper toxicology in piebald naked carp (Gymnocypris eckloni).

Background: Copper was used for many years in aquaculture operations as an effective algaecide or a parasite treatment of fish. It is an essential nutrient with numerous functions in organisms, but is toxic at high concentrations. However, the toxicity of copper to fish remains unclear.

Gene Sequencing Reveals the Effects of Successive Monoculture on the Soil Diazotrophic Microbial Community in Plantations.

The growth and productivity of is negatively impacted by planting sickness under long-term monoculture regimes. In this study, Illumina MiSeq sequencing targeting genes was used to assess variations in the rhizospheric soil diazotrophic community under long-term monoculture rotations. Principal component analysis and unweighted pair-group method with arithmetic means (UPGMA) clustering demonstrated distinct differences in diazotrophic community structure between uncultivated soil (CK), the first rotation plantation (FCP), the second rotation plantation (SCP), and the third rotation plantation (TCP).

A novel family of intrinsic chloramphenicol acetyltransferase CATC in Vibrio parahaemolyticus: Naturally occurring variants reveal diverse resistance levels against chloramphenicol.

Intrinsic resistance of bacteria to antibiotics plays an increasingly significant role in antibiotic resistance. However, the breadth of intrinsic resistance has not been fully elucidated. Here we identified a novel class of chloramphenicol acetyltransferase (type C CAT or CATC) in Vibrio parahaemolyticus and its closely related species V.

Five novel carbapenem-hydrolysing OXA-type β-lactamase groups are intrinsic in Acinetobacter spp.

Objectives: Carbapenem resistance in Acinetobacter spp. is increasing and is primarily associated with the expression of OXA-type β-lactamases. However, the role of intrinsic OXA-type β-lactamases in the carbapenem resistance of Acinetobacter spp.

Soil microbial community structure and catabolic activity are significantly degenerated in successive rotations of Chinese fir plantations.

This study examined the hypotheses that soil microbial community composition and catabolic activity would significantly degenerated by consecutive monoculture in Chinese fir plantations. The phospholipid fatty acids (PLFA) and community level physiological profiles (CLPP) methods were used to assess the variations of soil microbial community among the first rotation Chinese fir plantation (FCP), the second rotation plantation (SCP) and the third rotation plantation (TCP). The total content of PLFA biomarkers was highest in FCP, followed by SCP, and TCP was the least detected.

[The clinical characteristics of primary intracranial germinoma].

Objective: To analyse the clinical characteristics of intracranial germinoma.

Methods: Retrospective analysis was applied to study the clinical characteristics of 26 intracranial germ cell tumor patients admitted to our hospital during 1991-2003. The clinical, biochemical and imaging profiles including human chorionic gonadotropin-beta, alphafetoprotein, MRI and CT as well as treatments were analysed.