Macrophages regulate angiogenesis-osteogenesis coupling induced by mechanical loading through the Piezo1 pathway.

Bone is a mechanosensitive organ, and its regeneration also depends on the ability of bone cells to perceive and react to mechanical stimuli. Macrophages are indispensable for bone formation, regeneration, and maintenance. Depletion of macrophages resulted in poor bone development, due to impaired vessels formation and osteogenesis.

Co-delivery of vitamin and amino acid within MOFs for oxidative stress-based tumor gas therapy.

As an alternative to chemotherapy, emerging gas therapy is considered a "green" treatment due to its minimal side effects. However, even typical gas molecules like nitric oxide (NO) face challenges such as a very short half-life (1.5-6 min), poor targeting, and limited therapeutic effects.

Application progress of ultrasound in the production and processing of traditional Chinese herbal medicines.

The quality of Chinese herbal medicines is the key to the quality of traditional Chinese medicine. The processing of Chinese herbal medicines is an important part of the production and quality formation of medicinal materials. Traditional processing methods have low productivity and cannot guarantee the quality of Chinese herbal medicines.

Water-Vapor-Triggered Dual-Mode Optical Responses in Rare-Earth-Doped Hollow Nanospheres.

Multimode responsive optical materials are garnering ever-increasing attention due to their diverse applications. This work showcases a film assembled with rare-earth-doped CaF hollow nanospheres that exhibit water-vapor-triggered dual-mode optical responses. Upon exposure to flowing water vapor, the film rapidly (less than 1.

A new dammarane-type triterpenoid saponin from the leaves of sour jujube.

A new dammarane-type triterpenoid saponin, suanzaoside A () along with one known analogue 3--[-L-rhamnopyranosyl(1→2)--L-arabinopyranosyl-]-30--[-D-glucopyranosyl-(1→2)--D-glucopyranosyl]-3,25,30-trihydroxy-16-one-20,24-epoxydammarane (), were isolated from the leaves of sour jujube. The structure of these isolated compounds was elucidated by HRESIMS, 1D and 2D NMR spectroscopy, and literature comparison. In addition, the anti-inflammatory activities were further tested in LPS-induced RAW264.

Fully integrated multi-mode optoelectronic memristor array for diversified in-sensor computing.

In-sensor computing, which integrates sensing, memory and processing functions, has shown substantial potential in artificial vision systems. However, large-scale monolithic integration of in-sensor computing based on emerging devices with complementary metal-oxide-semiconductor (CMOS) circuits remains challenging, lacking functional demonstrations at the hardware level. Here we report a fully integrated 1-kb array with 128 × 8 one-transistor one-optoelectronic memristor (OEM) cells and silicon CMOS circuits, which features configurable multi-mode functionality encompassing three different modes of electronic memristor, dynamic OEM and non-volatile OEM (NV-OEM).

Research hot topics and frontiers in social anxiety over the past decade: a CiteSpace bibliometric analysis based on Web of Science database from 2013 to 2023.

Objective: To understand the current study of social anxiety (SA) over the past decade, and to analyze the research hot topics and frontiers in this field.

Methods: CiteSpace 6.2.

Distinct Effects of SARS-CoV-2 Protein Segments on Structural Stability, Amyloidogenic Potential, and α-Synuclein Aggregation.

Amyloidosis is characterized by the abnormal accumulation of misfolded proteins, called amyloid fibrils, leading to diverse clinical manifestations. Recent studies on the amyloidogenesis of SARS-CoV-2 protein segments have raised concerns on their potential link to post-infection neurodegeneration, however, the mechanisms remain unclear. Herein, we investigated the structure, stability, and amyloidogenic propensity of a nine-residue segment (SK9) of the SARS-CoV-2 envelope protein and their impact on neuronal protein α-synuclein (αSyn) aggregation.

High-current decoupled hydrogen and oxygen evolution via nickel-cobalt based redox mediators and bifunctional catalyst of 3D printing substrates.

The conversion of renewable energy sources with relatively large energy fluctuations into hydrogen represents a crucial aspect of energy storage. Nevertheless, the direct water electrolysis process is known to require excessive instantaneous energy consumption and high cost. Two-step alkaline water electrolysis is regarded as a secure and effective method of generating hydrogen from renewable energy sources when compared to direct water electrolysis.

Spatio-temporal pattern and coordinated development of eco-compensation performance of 101 cities in the Yangtze River Economic Belt.

Eco-compensation is an important component of ecological civilization construction. Therefore, it is of great significance to elucidate the spatial and temporal pattern of eco-compensation performance and its internal coupling and coordinated features to promote ecological civilization construction. We proposed that eco-compensation performance consists of benefit and efficiency, and used the projection pursuit and super-efficiency SBM-DEA models to measure the eco-compensation benefit and efficiency of 101 cities in the Yangtze River Economic Belt from 2010 to 2021 and to analyze their spatial and temporal patterns.

A gene cluster for polyamine transport and modification improves salt tolerance in tomato.

Polyamines act as protective compounds directly protecting plants from stress-related damage, while also acting as signaling molecules to participate in serious abiotic stresses. However, the molecular mechanisms underlying these effects are poorly understood. Here, we utilized metabolome genome-wide association study to investigate the polyamine content of wild and cultivated tomato accessions, and we discovered a new gene cluster that drove polyamine content during tomato domestication.

An Alternating-Electric-Field-Driven Assembly of DNA Nanoparticles into FCC Crystals.

Using an alternating electric field is a versatile way to control particle assembly. Programming DNA-AuNP assembly via an electric field remains a significant challenge despite the negative charge of DNA. In DNA-AuNP assembly, a critical percolation state is delicately constructed, where the DNA bond is loosely connected and sensitive to electric fields.

MiRNA expression profiling reveals a potential role of microRNA-148b-3p in cerebral vasospasm in subarachnoid hemorrhage.

Cerebral vasospasm (CVS) is an important contributor to delayed cerebral ischemia following aneurysmal subarachnoid hemorrhage (aSAH), leading to high morbidity and long-term disability. While several microRNAs (miRNAs) have been implicated in vasospasm, the underlying mechanisms for CVS remain poorly understood. Our study aims to identify miRNAs that may contribute to the development of CVS.

Can similarity of autistic traits promote neural synchronization?

People with similar levels of autistic traits are reported to exhibit better interactions than those with larger differences in autistic traits. However, whether this "similarity effect" exists at the neural level remains unclear. To address this gap, the present study employed functional near-infrared spectroscopy (fNIRS) hyperscanning technology to assess inter-brain synchronization (IBS) during naturalistic conversations among dyads with three types of autistic trait combinations (20 high-high, 22 high-low, and 18 low-low dyads).

Substituent-dependent [4+2] or [2+2] cycloadditions of phenylallenyl phosphine oxides with arynes.

A [4+2] cycloaddition strategy to assemble phenanthren-9-yldiphenylphosphine oxides is reported. This reaction relies on the strategic use of readily available phenylallenyl phosphine oxides as dienes to participate in [4+2] cycloaddition with arynes. Notably, benzo[][1,4]oxaphosphinin-4-iums can be controllably synthesized by simply tuning the substituents in the phosphine oxide unit through a [2+2] cycloaddition cascade.

Whole-genome sequencing reveals cellular origin of concomitant chronic lymphocytic leukemia and multiple myeloma: a case report.

Chronic lymphocytic leukemia (CLL) and multiple myeloma (MM) are hematological disorders affecting B cells. The clonal relationship between CLL and MM has not always been clarified, although this information is critical to understanding its pathogenesis. Here, we present a rare clinical case of synchronous CLL and MM.

A 150 years record of polycyclic aromatic compounds in the Sihailongwan Maar Lake, Northeast China: impacts of socio-economic developments and pollution control.

The geochemical composition of sediment cores can serve as a proxy for reconstructing past human and nature-driven environmental and climatic changes. We investigated the temporal variation in the concentrations and fluxes of polycyclic aromatic compounds (PACs) which include polycyclic aromatic hydrocarbons (PAHs), oxygenated PAHs, and azaarenes in the Sihailongwan Maar Lake and found that they remained low before 1950. The PAC concentrations and fluxes increased substantially since 1950, which was in good agreement with the fast socio-economic development, industrialization, and associated growth in fossil fuel consumption in China, particularly since the 1980s.

Tanshinone IIA potentiates the chemotherapeutic effect of doxorubicin against breast cancer cells and attenuates the cardiotoxicity of doxorubicin by regulating ERK1/2 pathway.

Doxorubicin (Dox) is frequently employed as a chemotherapy agent for breast cancer. As the chemotherapy moves forward, breast cancer cells tend to develop resistance to Dox, besides that, Dox are also easy to cause cardiotoxicity related to cumulative dose. Therefore, how to potentiate the chemosensitivity of breast cancer cells to Dox while attenuating its cardiotoxicity has become a research hotspot.

Astragaloside IV Treats Parkinson's Disease by Regulating the Proliferation and Differentiation of NSCs through the SHH-Nurr1 Pathway.

Recently, there has been a surge of interest in enhancing the differentiation of neural stem cells (NSCs) and supplementing dopamine neurons as a potential treatment for Parkinson's disease, the second most prevalent neurodegenerative disorder. Two factors, sonic hedgehog (SHH) and nuclear receptor-related 1 protein (Nurr1), have been identified as influential in NSCs differentiation. Additionally, Astragaloside IV (AS-IV), an active compound derived from , has also been discovered to impact NSCs differentiation.

Which organic contaminants should be paid more attention: Based on an improved health risk assessment framework.

The increasing chemical pollution of the drinking water is widely concerned. Large number of organic contaminants cannot be removed by conventional water treatment technology due to their low concentration, and long-term exposure may pose significant risks to human health. Which organic contaminants in drinking water should be given more attention has been a topic of great concern in recent years.

Structural analysis and biological activity of cell wall polysaccharides and enzyme-extracted polysaccharides from pomelo (Citrus maxima (Burm.) Merr.).

Pomelo peel is a valuable source of pectin, but research on its cell wall polysaccharides is limited. This study compared the cell wall polysaccharides of pomelo peel, enzyme-extracted polysaccharides of pomelo peel, and enzyme-extracted polysaccharides of whole pomelo fruit. Cell wall polysaccharides, including water-soluble pectin (WSP), chelator-soluble pectin (CSP), sodium carbonate-soluble pectin (NSP), 1 mol/L KOH soluble hemicellulose (KSH-1), and 4 mol/L KOH soluble hemicellulose (KSH-2), were obtained by sequence-extraction method.

[Biomechanical study of three-dimensional printed filler block design in open wedge high tibial osteotomy].

The use of a filling block can improve the initial stability of the fixation plate in the open wedge high tibial osteotomy (OWHTO), and promote bone healing. However, the biomechanical effects of filling block structures and materials on OWHTO remain unclear. OWHTO anatomical filling block model was designed and built.