NCU-08 ameliorated senescence modulation of the AMPK/Sirt1 signaling pathway and gut microbiota in mice.

Aging is a degenerative disease in which organisms and neurological functions decline. Emerging research has underscored the vital role of the gut microbiota in age-related processes. However, the identification of aging-associated core microbiota remains limited.

Rapid identification of pathogens associated with ventilator-associated pneumonia by Nanopore sequencing.

Background: Aetiology detection is crucial in the diagnosis and treatment of ventilator-associated pneumonia (VAP). However, the detection method needs improvement. In this study, we used Nanopore sequencing to build a quick detection protocol and compared the efficiency of different methods for detecting 7 VAP pathogens.

Performance and comparison of assessment models to predict 30-day mortality in patients with hospital-acquired pneumonia.

Background: Hospital-acquired pneumonia (HAP) is the most common hospital-acquired infection in China with substantial morbidity and mortality. But no specific risk assessment model has been well validated in patients with HAP. The aim of this study was to investigate the published risk assessment models that could potentially be used to predict 30-day mortality in HAP patients in non-surgical departments.

The diagnostic role of a short screening tool--the distress thermometer: a meta-analysis.

Purpose: The Distress Thermometer (the DT) is a commonly used screening tool to detect distress in cancer patients. This meta-analysis aims to examine the diagnostic role and the optimal cut-off score of the DT compared with various different reference standards.

Methods: We searched PubMed and Embase from 1997 to September 2013 for relevant studies.

Emerging role of microRNAs in cancer and cancer stem cells.

Cancer stem cells (CSCs), or cancer cells with stem cell properties, represent a small fraction of tumor bulk and are thought to be responsible for tumor formation and metastasis. However, the mechanisms of how CSCs are generated and regulated at the molecular level are poorly understood. Recent progress has highlighted the significance of microRNAs (miRNAs) in cancer progression and CSC function.