Effective interventions on health effects of Chinese rural elderly under heat exposure.

Unlabelled: Due to climate change, the heatwave has become a more serious public health threat with aging as an aggravating factor in recent years. There is a pressing need to detect the most effective prevention and response measures. However, the specific health effects of interventions have not been characterized on an individual scale.

Serum metabolite profiling of a 4-Nitroquinoline-1-oxide-induced experimental oral carcinogenesis model using gas chromatography-mass spectrometry.

Background: Oral cancer progresses from hyperplastic epithelial lesions through dysplasia to invasive carcinoma. The critical needs in oral cancer treatment are expanding our knowledge of malignant tumour progression and the development of useful approaches to prevent dysplastic lesions. This study was designed to gain insights into the underlying metabolic transformations that occur during the process of oral carcinogenesis.

Prevalence of and related risk factors in oral mucosa diseases among residents in the Baoshan District of Shanghai, China.

Background: Oral mucosal diseases (OMDs) encompass a variety of different types of diseases. Our aim was to evaluate the prevalence and related risk factors of OMDs among residents in the Baoshan District of Shanghai, China, and provide a scientific basis for prevention and control strategies.

Methods: A sample of 653 residents aged 17 to 92 years from the Baoshan community was investigated in 2014.

Linking elevated blood lead level in urban school-aged children with bioaccessible lead in neighborhood soil.

Lead (Pb) exposure is known to affect the health of children while soil Pb is an important contributor to human Pb exposure. To analyze the effects of both environmental and other factors, especially total and bioaccessible Pb in neighborhood soil, on school-aged urban children's blood lead level (BLL), 75 children (6-11 years old) were recruited from an industry city in eastern China for BLL measurement and questionnaire survey. Soil samples were collected from their living neighborhoods and measured for total and bioaccessible Pb.

Differential expression of ghrelin and GHSR via the mTOR pathway during the dynamic carcinogenic process involving oral, potentially malignant disorders.

The purpose was to explore the sequence changes in ghrelin and GHSR in the mTOR signaling pathway during carcinogenesis involving oral, potentially malignant disorders (OPMD). The samples were confirmed through in vivo pathologic tissue screening and diagnosis. The immunohistochemical method was used to detect the expression of the ghrelin/growth hormone secretagogue receptor (GHSR) protein.

LGR4 protects hepatocytes from injury in mouse.

Leucine-rich repeat G protein-coupled receptors (LGRs) and their endogenous ligands R-spondin1-4 (Rspo) are critical in embryonic development and in maintenance of stem cells. The functions of the Rspo-LGR system in differentiated cells remain uncharacterized. In this study, the expression profiles of LGRs and Rspos were characterized in mature hepatocytes.

Dynamic changes in the gene expression profile during rat oral carcinogenesis induced by 4-nitroquinoline 1-oxide.

The typical progression of oral cancer is from hyperplastic epithelial lesions through dysplasia to invasive carcinoma. It is important to investigate malignant oral cancer progression and development in order to determine useful approaches of prevention of dysplastic lesions. The present study aimed to gain insights into the underlying molecular mechanism of oral carcinogenesis by establishing a rat model of oral carcinogenesis using 4‑nitroquinoline 1‑oxide.

[The study of cytotoxicity of different intracanal medications and cell rehabilitation on human periodontal ligament fibroblasts].

Purpose: To determine the cytotoxicity and reversibility of cytotoxicity of 5 intracanal medications in various concentrations with human periodontal ligament fibroblasts (HPLFs), with the aim to provide a comprehensive reliable scientific evidence for making a good choice of these intracanal medications in clinical practice.

Methods: The experimental medications included formocresol (FC), camphorated paramonochlorophenol(CP), metronidazole, calcium hydroxide and traditional Chinese medicine. HPLFs were obtained from healthy premolars extracted for orthodontic reasons.