New insights into the controlling factors of nitrate spatiotemporal characteristics in groundwater of Dagu aquifer in Qingdao, China.

Identifying spatiotemporal variation of groundwater NO-N and its primary controlling factors are vital for groundwater protection. This study, under the data scarce conditions and based on time series monitoring data in Dagu aquifer, applied methods including hydrochemical ion ratio, multiple linear regression, support vector regression and grey relational analysis and dedicated to revealing primary controlling factors of temporal variation patterns of groundwater NO-N. The results showed that agricultural and manure fertilizer are the main sources of NO-N in north and central area (vegetable farming area), and that domestic sewage discharge and manure fertilizer are the main sources of NO-N in south area (residential and grain planting area).

Predicting Metformin Efficacy in Improving Insulin Sensitivity Among Women With Polycystic Ovary Syndrome and Insulin Resistance: A Machine Learning Study.

Objective: Metformin is clinically effective in treating polycystic ovary syndrome (PCOS) with insulin resistance (IR), while its efficacy varies among individuals. This study aims to develop a machine learning model to predict the efficacy of metformin in improving insulin sensitivity among women with PCOS and IR.

Methods: This is a retrospective analysis of a multicenter, randomized controlled trial involving 114 women diagnosed with PCOS and IR.

VirBR, a transcription regulator, promotes IncX3 plasmid transmission, and persistence of bla in zoonotic bacteria.

IncX3 plasmids carrying the New Delhi metallo-β-lactamase-encoding gene, bla, are rapidly spreading globally in both humans and animals. Given that carbapenems are listed on the WHO AWaRe watch group and are prohibited for use in animals, the drivers for the successful dissemination of Carbapenem-Resistant Enterobacterales (CRE) carrying bla-IncX3 plasmids still remain unknown. We observe that E.

Factors associated with risk analysis for asymptomatic left ventricular diastolic dysfunction in nondialysis patients with chronic kidney disease.

Heart failure (HF) constitutes a major determinant of outcome in chronic kidney disease (CKD) patients. The main pattern of HF in CKD patients is preserved ejection fraction (HFpEF), and left ventricular diastolic dysfunction (LVDD) is a frequent pathophysiological mechanism and specific preclinical manifestation of HFpEF. Therefore, exploring and intervention of the factors associated with risk for LVDD is of great importance in reducing the morbidity and mortality of cardiovascular disease (CVD) complications in CKD patients.

Predicting acupuncture efficacy for major depressive disorder using baseline clinical variables: A machine learning study.

Acupuncture is a viable treatment option for major depressive disorder (MDD). However, its effectiveness varies among patients. This study aimed to develop a model to predict the efficacy of acupuncture therapy for MDD using machine learning and baseline clinical variables.

Lack of Rab27a attenuates foam cell formation and macrophage inflammation in uremic apolipoprotein E knockout mice.

As the most common cardiovascular disease, atherosclerosis (AS), is a leading cause of high mortality in patients with chronic renal failure. Rab27a has been reported to regulate the progression of cardiovascular and renal diseases. Nevertheless, little studies investigated the role and mechanism of Rab27a in uremic-accelerated AS (UAAS).

Efficacy of electroacupuncture in assisting postoperative healing of distal radius fractures: study protocol for a randomized controlled trial.

Background: Manual reduction and surgical treatment are common methods for distal radius fractures (DRFs). The existing literature suggests that postoperative combined rehabilitation treatment and medication are effective for the healing of DRFs. However, the side effects of these treatments remain to be solved.

Spreading of -Carrying Plasmids among Staphylococci from Humans and Animals.

The multidrug resistance gene mediates resistance to multiple antimicrobial agents, including linezolid. Plasmids are the preferred vector for the dissemination of . However, the presence and transmission of -carrying plasmids among staphylococci from humans and animals have rarely been studied.

Electronic cigarettes versus nicotine-replacement therapy for smoking cessation: A systematic review and meta-analysis of randomized controlled trials.

Introduction: Nicotine-replacement therapy (NRT) and electronic cigarettes (e-cigarettes) have been frequently used for smoking cessation. The aim of this review is to investigate the effectiveness and safety of e-cigarettes versus NRT for smoking cessation.

Methods: We searched PubMed, EMBASE, the Cochrane Library from inception to 10 October 2021.

Fitness Cost of -Carrying p3R-IncX3 Plasmids in Wild-Type NDM-Free .

The wide dissemination of New Delhi metallo-β-lactamase genes () has resulted in the treatment failure of most available β-lactam antibiotics, with IncX3-type -carrying plasmids recognised as having spread worldwide. In China, bacteria carrying these plasmids are increasingly being detected from diverse samples, including hospitals, communities, livestock and poultry, and the environment, suggesting that IncX3 plasmids are becoming a vital vehicle for dissemination. To elucidate the fitness cost of these plasmids on the bacterial host, we collected -negative strains from different sources and tested their ability to acquire the -harboring p3R-IncX3 plasmid.

Co-existence of two novel phosphoethanolamine transferase gene variants in Aeromonas jandaei from retail fish.

Two novel phosphoethanolamine transferase genes, eptAv7 and eptAv3, were identified in the chromosome of an Aeromonas jandaei isolate from retail fish. The variants showed 79.9% and 80.