The Association Between Brominated Flame Retardants Exposure and Liver-Related Biomarkers in US Adults.

Emerging studies demonstrate that exposure to brominated flame retardants (BFRs) can have harmful effects on human health. Our study focused on the relationship between exposure to various BFRs and markers of liver function. To further explore the association between BFR exposure and liver function impairment, we used data from the National Health and Nutrition Examination Surveys (NHANES) for three cycles from 2009 to 2014, leaving 4206 participants (≥20 years of age) after screening.

Nitrogen-doped porous hydrochar for enhanced chromium(VI) and bisphenol A scavenging: Synergistic effect of chemical activation and hydrothermal doping.

Nitrogen-doped porous hydrochar (NPHC) was successfully synthesized by hydrothermal carbonization and activation with KHCO, which was employed for scavenging hexavalent chromium (Cr(VI)) and bisphenol A (BPA) in contaminated water. N doping increased the unique active sites such as amino and molecular N in NPHC for adsorbing contaminants, and enhanced the activation effect. Compared to original (HC) and N-doped hydrochar (NHC), the S of material improved from 3.

Outcomes of allogeneic hematopoietic stem cell transplantation versus intensive chemotherapy in patients with myeloid sarcoma: a nationwide representative multicenter study.

Myeloid sarcoma (MS) is a rare hematological neoplasm with poor prognosis, posing a significant clinical challenge due to the absence of effective and standardized treatments. We conducted a retrospective analysis of 162 MS patients treated at 12 centers to compare outcomes between intensive chemotherapy and allogeneic hematopoietic stem cell transplantation (allo-HSCT). Our analysis revealed that allo-HSCT demonstrated superior overall survival (OS) within the initial 36 months compared to intensive chemotherapy alone (p = 0.

Multi-omics profiling reveals elevated CO-enhanced tolerance of Trifolium repens L. to lead stress through environment-plant-microbiome interactions.

The increasing atmospheric CO resulting from human activities over the past two centuries, which is projected to persist, has significant implications for plant physiology. However, our predictive understanding of how elevated CO (eCO) modifies plant tolerance to metal stress remains limited. In this study, we collected roots and rhizosphere soils from Trifolium repens L.

Synthesis of magnetic chitosan-composite biochar and its removal of copper ions (Cu) and methylene blue (MB) dye from aqueous solutions.

This study presents the synthesis and evaluation of a magnetic chitosan-modified biochar (M-BC-CS) composite, developed from waste maize straw, for the efficient removal of copper ions (Cu) and methylene blue (MB) dye from aqueous solutions. The composite was characterized using advanced techniques such as SEM, BET, FTIR, XPS, and XRD, confirming its enhanced surface area, porosity, and magnetic properties. The study is aimed at investigating the optimal conditions for adsorption of Cu and MB by M-BC-CS through analysis of the influence of diverse adsorbent dosages, pH levels, reaction times, and initial solution concentrations.

Exploring the prognostic value of T follicular helper cell levels in chronic lymphocytic leukemia.

Chronic lymphocytic leukemia (CLL) presents with heterogeneous clinical outcomes, suggesting varied underlying pathogenic mechanisms. This study aims to elucidate the impact of T follicular helper (Tfh) cells on CLL progression and prognosis. Gene expression profile data for CLL were collected from GSE22762 and GSE39671 datasets.

Effective removal of Cr(VI) from water by ball milling sulfur-modified micron zero-valent iron：Influencing factors and removal mechanism.

To address the issues of ZVI's susceptibility to oxidation and aggregation, ball milling and NaS·9HO modification were employed on ZVI to enhance its efficiency in removing Cr(VI) from effluent. The characterization results expressed that S-mZVI had mesoporous and macroporous structures, enabling successful capture of Cr(VI). Moreover, S-mZVI had the highest adsorption capacity for Cr(VI) (350.

Effective amendment of cadmium in water and soil before and after aging of nitrogen-doped biochar: Preparation optimization, removal efficiency and mechanism.

Nitrogen-doped biochar (NBC) is a green material for remediating heavy metal pollution, but it undergoes aging under natural conditions, affecting its interaction with heavy metals. The preparation conditions of NBC were optimized using response surface methodology (RSM), and NBC was subjected to five different aging treatments to analyze the removal efficiency of Cd(II) and soil remediation capability before and after aging. The results indicated that NBC achieved optimal performance with a mass ratio of 5:2.

Metal-doped biochar for selective recovery and reuse of phosphate from water: Modification design, removal mechanism, and reutilization strategy.

Phosphorus (P) plays a crucial role in plant growth, which can provide nutrients for plants. Nonetheless, excessive phosphate can cause eutrophication of water, deterioration of aquatic environment, and even harm for human health. Therefore, adopting feasible adsorption technology to remove phosphate from water is necessary.

Effect of Bioactive Black Phosphorus Nanomaterials on Cancer-Associated Fibroblast Heterogeneity in Pancreatic Cancer.

Tumor-stromal interactions and stromal heterogeneity in the tumor microenvironment are critical factors that influence the progression, metastasis, and chemoresistance of pancreatic ductal adenocarcinoma (PDAC). Here, we used spatial transcriptome technology to profile the gene expression landscape of primary PDAC and liver metastatic PDAC after bioactive black phosphorus nanomaterial (bioactive BP) treatment using a murine model of PDAC (; ; and mice). Bioinformatic and biochemical analyses showed that bioactive BP contributes to the tumor-stromal interplay by suppressing cancer-associated fibroblast (CAF) activation.

Multi-output neural network model for predicting biochar yield and composition.

In biomass pyrolysis for biochar production, existing prediction models face computational challenges and limited accuracy. This study curated a comprehensive dataset, revealing pyrolysis parameters' dominance in biochar yield (54.8 % importance).

Acute exposure to polystyrene nanoplastics induces unfolded protein response and global protein ubiquitination in lungs of mice.

Inhaling microplastics (MPs) and nanoplastics (NPs) in the air can damage lung function. Xenobiotics in the body can cause endoplasmic reticulum (ER) stress, and the unfolded protein response (UPR) activation alleviates ER stress. Degradation of unfolded or misfolded proteins is an important pathway for recovering cellular homeostasis.

The performance of quaternary-ammonium chitosan in wastewater treatment: The overlooked role of solubility.

Quaternary-ammonium chitosan (CT-CTA) is a popular water treatment agent, and its electropositivity and cation strength are improved compared with chitosan. The use of CT-CTA is widely advocated to remove suspended particles and organic matter from wastewater. However, the solubility of CT-CTA is an important factor affecting the performance of CT-CTA, which is a neglected problem in previous studies.

Study on the mechanism and degradation behavior of Encifer adhaerens DNM-S1 capturing dimethyl phthalate.

The global concern surrounding pollution caused by phthalates is escalating, with dimethyl phthalate (DMP) emerging as one of the most prevalent contaminants within the phthalates (PAEs) category. Although the biodegradation of DMP is considered both safe and efficient, its underlying degradation mechanism is not yet fully elucidated, and the degradation performance can be somewhat inconsistent. To address this issue, our study isolated a DMP-degrading bacterium (DNM-S1) from a vegetable greenhouse.

Combined effects of polystyrene nanoplastics and lipopolysaccharide on testosterone biosynthesis and inflammation in mouse testis.

Microplastics (MPs)/nanoplastics (NPs), as a source and vector of pathogenic bacteria, are widely distributed in the natural environments. Here, we investigated the combined effects of polystyrene NPs (PS-NPs) and lipopolysaccharides (LPS) on testicular function in mice for the first time. 24 male mice were randomly assigned into 4 groups, control, PS-NPs, LPS, and PS-NPs + LPS, respectively.

[Proportion and Clinical Significance of γδT17/Th17/Tc17 Cells in Peripheral Blood of Uygur Patients with Chronic Lymphoblastic Leukemia].

Objective: To explore the distribution of γδT17/Th17/Tc17 cells in the peripheral blood of Uygur patients with chronic lymphoblastic leukemia (CLL) and clinical significance.

Methods: ELISA method was used to detect the levels of IL-17, IL-23, IL-6, and IFN-γ in the peripheral blood serum of 53 newly diagnosed Uygur patients with CLL and 30 healthy controls. Flow cytometry was used to determine the proportion of γδT/γδT17/Th17/Tc17 cells in the peripheral blood of Uygur CLL patients and controls, and the changes of the abover indexes in CLL Binet staging were observed.

Fe/N co-doped magnetic porous hydrochar for chromium(VI) removal in water: Adsorption performance and mechanism investigation.

Four kinds of Fe/N co-doped porous hydrochar were prepared by one/two-step N-doping schemes using microwave/traditional pyrolysis methods for removing Cr(VI) from aqueous phase. Heterocyclic-N was introduced through CO(NH)-based hydrothermal carbonization process, which could adjust the electronic structure of the hydrochar framework. Furthermore, Fe and FeO were embedded into hydrochar via carbothermal reduction reaction using FeCl as the precursor, which improved the reducibility and magnetism of the material.

Biodegradation of atrazine with biochar-mediated functional bacterial biofilm: Construction, characterization and mechanisms.

The abuse and residue of herbicides in the black soil area had seriously affected the soil structure, function and crop growth, posing severe threats to agricultural soil environment and public health. Given the limitation of routine microbial remediation, innovative and eco-friendly functional bacterial biofilm which could adapt under adverse conditions was developed on the biochar to investigate its enhanced bioremediation and metabolic characteristics of typical herbicide atrazine. Results revealed that the atrazine degrading strain Acinetobacter lwoffii had competitive advantage in soil indigenous microorganisms and formed dense biofilms on the biochar which was beneficial to cell viability maintenance and aggregations.

Activated Tim-3/Galectin-9 participated in the development of multiple myeloma by negatively regulating CD4 T cells.

The interaction between Tim-3 on T cells and its ligand Galectin-9 negatively regulates the cellular immune response. However, the regulation of Tim-3/Galectin-9 on CD4 T cell subsets in multiple myeloma (MM) remains unclear. The aim of this study was to investigate the relationship between the regulation of CD4 T cell subsets by the Tim-3/Galectin-9 pathway and clinical prognostic indicators in MM.

[Significance of Tim-3 and Its Ligand Galectin-9 in Th1/Th2 Imbalance in Patients with Multiple Myeloma].

Objective: To investigate the significance of Tim-3 and Galectin-9 in Th1/Th2 imbalance in patients with multiple myeloma (MM).

Methods: 55 newly diagnosed MM patients and 20 healthy controls were included. Flow cytometry was used to detect the expression of Tim-3 on CD4T cells, the proportion of Th1, Th2, Tim-3Th1 and Tim-3Th2 cells in peripheral blood.

[Expression and Clinical Significance of Helper T Cells 9 and Its Sytokines Interleukin 9 in Chronic Lymphocytic Leukemia].

Objective: To investigate the expression and clinical significance of T helper cell 9 (Th9) and its cytokine interleukin 9(IL-9) in peripheral blood of patients with chronic lymphocytic leukemia(CLL).

Methods: A total of 43 newly diagnosed patients with chronic lymphocytic leukemia in the First Affiliated Hospital of Xinjiang Medical University from June 2021 to June 2022 were selected as the case group. The patients were divided into Binet A group (13 cases), Binet B group (20 cases) and Binet C group (10 cases) by Binet staging system, and 20 healthy volunteers who underwent physical examinationin in our hospital in the same period served as control group.

Superior reduction and immobilization of Cr(VI) in soil utilizing sulfide nanoscale zero-valent iron supported by phosphoric acid-modified biochar: Efficiency and mechanism investigation.

A novel strategy was proposed to remediate Cr(VI)-contaminated soil via phosphoric acid-modified biochar supported sulfide nanoscale zero-valent iron (SnZVI@PBC). Results of characterizations revealed that FeS shell existed in outer layer of nZVI to prevent its oxidation after sulfidation modification, and SnZVI was effectively dispersed owing to the support of PBC, accelerating the electron transport for Cr(VI) reduction. The SnZVI@PBC presented pH-dependence and fast capture for Cr(VI) with outstanding binding amount of 335.

Screening the optimal modified biochar for nitrogen retention in black soil.

Reducing the environmental problems caused by nitrogen loss and nitrogen pollution is of great significance. The addition of biochar to soil is a new method for increasing nitrogen interception due to the special structural and physicochemical properties of biochar. The optimal modified biochar was screened out after acid-base modification and batch adsorption test in this paper.