Identification Method for Railway Rail Corrugation Utilizing CEEMDAN-PE-SPWVD.

Rail corrugation intensifies wheel-rail vibrations, often leading to damage in vehicle-track system components within affected sections. This paper proposes a novel method for identifying rail corrugation, which combines Complete Ensemble Empirical Mode Decomposition with Adaptive Noise (CEEMDAN), permutation entropy (PE), and Smoothed Pseudo Wigner-Ville Distribution (SPWVD). Initially, vertical acceleration data from the axle box are decomposed using CEEMDAN to extract intrinsic mode functions (IMFs) with distinct frequencies.

Design and application of synthetic 17B-HSD13 substrates reveals preserved catalytic activity of protective human variants.

Several hydroxysteroid dehydrogenase 17-beta 13 variants have previously been identified as protective against metabolic dysfunction-associated steatohepatitis (MASH) fibrosis, ballooning and inflammation, and as such this target holds significant therapeutic potential. However, over 5 years later, the function of 17B-HSD13 remains unknown. Structure-aided design enables the development of potent and selective sulfonamide-based 17B-HSD13 inhibitors.

Fish oil emulsions stabilized by enzymatic hydrolysis, glycation, and fibrillation of β-Lg: Stability and EPA/DHA bioaccessibility.

This study investigated the stabilization mechanism, storage stability, and in vitro digestion characteristics of oil-in-water fish oil emulsions stabilized by β-Lg modified through enzymatic hydrolysis, glycation, and fibrillation. The stabilization mechanism was elucidated by comparing droplet size, ζ-potential, interfacial protein thickness, and microstructure. Results showed that β-Lg modified through these combined processes formed a three-dimensional network, providing superior stabilization, while other modified proteins stabilized emulsions via surface adsorption.

Prolamin-pectin complexes: Structural properties, interaction mechanisms and food applications.

Prolamin, a class of plant protein mainly derived from grains, and pectins, complex-structured polysaccharides, are natural biological macromolecules with versatile functional properties. The interactions between prolamins and pectin have been widely studied and applied, demonstrating that both covalent and non-covalent interactions play pivotal roles in the formation of prolamin-pectin complexes. These interactions impart exceptional physicochemical and functional properties to the complexes.

circARID1A Inhibits Tail Fat Cell Differentiation in Guangling Large-Tailed Sheep by Regulating the miR-493-3p/YTHDF2 Axis.

The Guangling Large-Tailed sheep is renowned for its unique tail fat deposition, with a significant proportion of its total body fat being localized in the tail region. Fat deposition is a complex biological process regulated by various molecular mechanisms. Our previous studies have identified a large number of differentially expressed circular RNAs (circRNAs) in the tail adipose tissue of the Guangling Large-Tailed sheep.

Effect of pectin with different esterification degree on the freeze-thaw stability of gluten protein: Structures, functional properties, and Cryoprotective mechanism.

The effect of degree of esterification (DE) on the cryoprotective function of pectin against the frozen deterioration of gluten protein is still unclear. Here, NMR, HPSEC-MALLS, HPGPC and optical microscrope were applied to determine the structure and ice recrystallization inhibition (IRI) activity of pectin with varying DE. The effect on structure, physicochemical properties and molecular interaction of gluten supplemented with pectin were investigated.

High level non-carbapenemase carbapenem resistance by overlaying mutations of , and in .

Unlabelled: Carbapenem-resistant (CRPA) is a global threat, but the mechanism of non-carbapenemase carbapenem resistance is still unclear. In the current study, we investigated the contributions of point mutations in , , and to carbapenem resistance in during evolution studies with consecutive clinical isolates. Real-time qPCR and Electrophoretic Mobility Shift Assay demonstrated that MexR (Gln55Pro) mutation increased MexAB efflux pump genes expression by altering MexR's binding capacity, leading to a four- to eight-fold increase in meropenem MIC in the Pae d1 Green ∆ and PAO1∆ mutants.

EYA3 promotes the tumorigenesis of gastric cancer through activation of the mTORC1 signaling pathway and inhibition of autophagy.

Gastric cancer (GC) is a leading cause of cancer-related mortality, with a high rate of postoperative recurrence and poor long-term survival. The Eyes Absent (EYA) protein family plays a significant role in cancer progression, with EYA3 being implicated in promoting GC cell proliferation and tumor growth. Utilizing the DepMap database, we identified EYA3 as a gene of interest in GC.

A Multi-Functional Cascade Nanoreactor for Remodeling Tumor Microenvironment to Realize Mitochondria Dysfunction via ROS/Zn Ions Overload.

Combining chemo/photodynamic therapy (CDT/PDT) to generate highly harmful reactive oxygen species and cause mitochondria dysfunction is considered a potential strategy to improve the efficiency of anticancer treatment. However, within tumor, the relatively deficient concentration of HO, hypoxic microenvironment, and overexpressed reduced glutathione (GSH) seriously suppress the efficacy of dynamic therapy. Herein, a multi-functional cascade nanoreactor, bovine serum albumin modified ZnO@CeO-ICG, is reported for remodeling tumor microenvironment (TME) to boost dynamic therapy and realize mitochondria dysfunction via reactive oxygen species (ROS) storm/Zn ions overload.

Corrigendum: Classification of autism spectrum disorder using electroencephalography in Chinese children: a cross- sectional retrospective study.

[This corrects the article DOI: 10.3389/fnins.2024.

Mechanism of promoting okara insoluble to soluble dietary fiber by high-pressure homogenization-microbial fermentation.

This study investigated the conversion of okara insoluble dietary fiber (IDF) to soluble dietary fiber (SDF) using high-pressure homogenization (HPH) combined with microbial fermentation. The conversion mechanism was analyzed from four aspects: correlation, proteomics, component and structure under. Results indicated a negative correlation between pH and SDF yield (r = -0.

Genetic Diversity and Selection Signatures of Lvliang Black Goat Using Genome-Wide SNP Data.

Lvliang black goat (LBG) is an excellent local breed resource in China that is known for its black fur, excellent meat quality, and strong adaptability. Studying the genetic mechanism and germplasm characteristics of LBG can provide theoretical and practical basis for the protection of the genetic resources of this breed and help implement conservation and breeding. In this study, the genetic diversity of the LBG population was evaluated using whole-genome SNP data.

Analysis of the Ni-5%at.W Alloy Substrate Texture Evolution at Different Strain Levels Using the EBSD Technique.

In this paper, the texture evolution of the Ni-5%W alloy baseband with different strain variables ( = 3.9, 4.9, and 5.

Revealing sRNA expression profiles of NDM-5-producing CRKP and explore the role of sRNA207 in NDM-5-producing CRKP resistance.

Unlabelled: New Delhi metallo-beta-lactamase-5 (NDM-5)-producing carbapenem-resistant (CRKP) is characterized by high virulence, high morbidity, and mortality, and the detection rate in children has increased in recent years. Therefore, it is urgent to develop new therapeutic targets and strategies. Non-coding small RNA (sRNA)-mediated RNA-based therapies offer a new direction for the treatment of bacterial infections, especially resistant bacteria.

Copper sulfides (CuS) nanowires with Ag anchored in N-doped carbon layers optimize interfacial charge transfer for rapid water sterilization.

There are many methods of water disinfection, and how to realize low energy consumption, high efficiency and safety sterilization has always been a research hotspot. In this work, CuS nanowires were grown on copper foam, and coated with N-doped carbon layer and Ag particles, which not only improved the conductivity and local field enhancement regions of the material, but also improved the durability and mechanical stability of CuS. DFT (Density functional theory) calculation shows that different kinds of N doping make the electron difference density and work function of the surrounding C different, which leads to high carrier transport capacity at the interface, and Ag anchored in N-doped carbon films can adsorb O.

Screening of Cancer-Specific Biomarkers for Hepatitis B-Related Hepatocellular Carcinoma Based on a Proteome Microarray.

Hepatocellular carcinoma (HCC) is associated with one of the highest mortality rates among cancers, rendering its early diagnosis clinically invaluable. Serum biomarkers, specifically alpha-fetoprotein (AFP), represent the most promising and widely used diagnostic biomarkers for HCC. However, its detection rate is low in the early stages of HCC progression, and distinguishing specific false positives for other liver-related diseases, such as cirrhosis and acute hepatitis, remains challenging.

Changes in serum uric acid, glutathione, and amyloid-β1-42 levels in Parkinson's disease patients and their association with disease progression and cognitive decline.

Objective: This study aims to evaluate the diagnostic significance of serum uric acid (UA), glutathione (GSH), and amyloid-β1-42 (Aβ1-42) levels in relation to disease progression and cognitive impairment in patients with Parkinson's disease (PD).

Methods: A total of 209 PD patients with disease duration ranging from 4.0 to 6.

Engineering Optimization of Producing High-Purity Dichlorosilane in a Fixed-Bed Reactor by Trichlorosilane Decomposition.

High-purity dichlorosilane (DCS) is an important raw material for thin film deposition in the semiconductor industry, such as epitaxial silicon, which is mainly produced by trichlorosilane (TCS) catalytic decomposition in a fixed-bed reactor. The productivity of DCS is strongly dependent on the controlling of the TCS decomposition reaction process, associated with the cost in practical application. In this study, we have performed computational fluid dynamics (CFD) simulation on the TCS decomposition reaction kinetics in a cylindrical fixed-bed reactor, in which the effects of catalyst bed height, feed temperature, and feed flow rate are stressed to predict the conversion rate of TCS and the generation rate of DCS.

Modified cardiopulmonary bypass circuit for transcatheter aortic valve implantation and emergent cardiac surgery.

Transcatheter aortic valve implantation (TAVI) has revolutionized the treatment of severe aortic stenosis in high-risk patients, offering a minimally invasive alternative to open-heart surgery. However, complications such as hemodynamic instability may require mechanical circulatory support. In some cases, emergent cardiac surgery may be required, necessitating a swift transition to cardiopulmonary bypass (CPB).

Algorithm Analysis and Optimization of a Digital Image Correlation Method Using a Non-Probability Interval Multidimensional Parallelepiped Model.

Digital image correlation (DIC), a widely used non-contact measurement technique, often requires empirical tuning of several algorithmic parameters to strike a balance between computational accuracy and efficiency. This paper introduces a novel uncertainty analysis approach aimed at optimizing the parameter intervals of a DIC algorithm. Specifically, the method leverages the inverse compositional Gauss-Newton algorithm combined with a prediction-correction scheme (IC-GN-PC), considering three critical parameters as interval variables.

Identification of and sp. in Malayan pangolins-a potential threat to public health?

Unlabelled: The discovery of severe acute respiratory syndrome-coronavirus-2-like and Middle East respiratory syndrome-coronavirus-like viruses in Malayan pangolins has raised concerns about their potential role in the spread of zoonotic diseases. Herein, we describe the isolation and whole-genome sequencing of potentially zoonotic two bacterial pathogens from diseased Malaysian pangolins ()- and sp. The newly identified species were designated as P69 and sp.

Breaking Latent Infection: How ORF37/38-Deletion Mutants Offer New Hope against EHV-1 Neuropathogenicity.

Equid alphaherpesvirus 1 (EHV-1) has been linked to the emergence of neurological disorders, with the horse racing industry experiencing significant impacts from outbreaks of equine herpesvirus myeloencephalopathy (EHM). Building robust immune memory before pathogen exposure enables rapid recognition and elimination, preventing infection. This is crucial for effectively managing EHV-1.

New progress in HBV control and the cascade of health care for people living with HBV in China: evidence from the fourth national serological survey, 2020.

Background: Since 1992, when recombinant hepatitis B vaccine was introduced in China, government health officials have used nationally representative serological surveys to monitor progress in prevention and control of hepatitis B. In 2020, we conducted the fourth seroepidemiological survey, which for the first time included medical evaluation of the clinical status of HBsAg positive subjects over the age of 15 and their medical management. We report survey results in comparison with the three previous surveys.