Publications by authors named "Jianhua Fu"
Background: Many studies have reported the important role of glucagon-like peptide-1 receptor (GLP-1R) in regulating glucose homeostasis. However, in addition to the pancreas, GLP-1R is distributed in organs such as the lungs. A few researches have reported the mechanism of action of GLP-1R in acute and chronic lung diseases.
View Article and Find Full Text PDFPrimary malignant melanoma of the esophagus (PMME) is a malignant tumor with a poor prognosis. This study aimed to conduct survival analysis for patients with PMME and propose a staging system for PMME. Data from 179 patients were compiled for survival analysis and to propose a staging system for PMME.
View Article and Find Full Text PDFBackground: The use of surrogate endpoints may expedite the reporting of study outcomes of clinical trials. The validity of disease-free survival (DFS) as a surrogate for overall survival (OS) in the neoadjuvant treatment of esophageal (E) or gastroesophageal junctional (GEJ) carcinomas remains uncertain.
Objective: To evaluate DFS as a surrogate end-point for OS in E/GEJ using the meta-analytical approach DESIGN, SETTING, AND PARTICIPANTS: individual patient data from an international meta-analysis on operable locally advanced E/GEJ, which including randomized trials comparing at least two of the neo-adjuvant treatment strategies: upfront surgery (S), chemotherapy followed by surgery (CS), and/or chemoradiotherapy followed by surgery (CRS).
This article explored the specific mechanism by which ginsenoside Rg_1 regulates cellular autophagy to attenuate hypoxia/reoxygenation(H/R) injury in HL-1 cardiomyocytes through the microRNA155(miR-155)/neurogenic gene Notch homologous protein 1(Notch1)/hairy and enhancer of split 1(Hes1) pathway. An HL-1 cell model with H/R injury was constructed, and ginsenoside Rg_1 and/or Notch1 inhibitor DAPT and miR-155 mimics were used to treat cells. Cell counting kit(CCK)-8 was used to detect the relative viability of HL-1 cells with H/R injury.
View Article and Find Full Text PDFThis study aimed to investigate the potential mechanism and the compatibility significance of Tanyu Tongzhi Formula in treating atherosclerosis(AS) in mice based on the transforming growth factor-β(TGF-β)/Smad2/3 signaling pathway. Eight C57BL/6J mice were as assigned to a normal control group and fed a regular diet, while 35 ApoE~(-/-) mice of the same strain were fed a high-fat diet for 8 weeks to establish an AS model. The model mice were randomly divided into a model group, a Tanyu Tongzhi group(18.
View Article and Find Full Text PDFObjectives: This study intended to explore whether the protective effect safflower yellow injection (SYI) on myocardial ischemia-reperfusion (I/R) injury in rats mediated of the NLRP3 inflammasome signaling.
Methods: The I/R model was prepared by ligating the left anterior descending coronary artery for 45 min and then releasing the blood flow for 150 min. 96 male Wistar rats were randomly divided into sham group, I/R group, Hebeishuang group (HBS), SYI high-dose group (I/R + SYI-H), SYI medium-dose group (I/R + SYI-M) and SYI low-dose group (I/R + SYI-L).
The influence of the mitochondrial control system on ischemic heart disease has become a major focus of current research. Mitophagy, as a very crucial part of the mitochondrial control system, plays a special role in ischemic heart disease, unlike mitochondrial dynamics. The published reviews have not explored in detail the unique function of mitophagy in ischemic heart disease, therefore, the aim of this paper is to summarize how mitophagy regulates the progression of ischemic heart disease.
View Article and Find Full Text PDFBackgroud: Recent studies have reported mitochondrial damage and metabolic dysregulation in BPD, but the changes in mitochondrial dynamics and glucose metabolic reprogramming in ATII cells and their regulatory relationship have not been reported.
Methods: Neonatal rats in this study were divided into model (FIO2:85%) and control (FIO2: 21%) groups. Lung tissues were extracted at 3, 7, 10 and 14 postnatal days and then conducted HE staining for histopathological observation.
Article Synopsis
- This study explores how ginsenoside Rg_1 protects heart cells (HL-1 cardiomyocytes) from damage caused by low oxygen (hypoxia) followed by reoxygenation, focusing on its ability to inhibit the acetylation of a protein called ATP5A1 through the action of SIRT3.
- The researchers created an injury model by exposing the cells to 6 hours of hypoxia and 2 hours of reoxygenation, measuring cell damage and the effects of ginsenoside Rg_1 on various biological markers, including cell death and energy production.
- Results indicated that ginsenoside Rg_1 significantly reduced cell injury and apoptosis, increased the expression of SIRT3, and improved mitochondrial function compared to
Article Synopsis
- * Using the Gene Expression Omnibus database, researchers identified three key genes that can predict how well ESCC patients respond to neoadjuvant chemoradiotherapy and are associated with immune cell activity.
- * A prognostic nomogram was created that combines these key genes with clinical data, showing reliable predictions for ESCC outcomes while revealing the genes' roles in important tumor signaling pathways, such as epithelial-mesenchymal transition and P53.
Background: Due to its rarity, it is challenging to predict the survival of patients with synchronous multiple primary esophageal squamous carcinomas (SMPESCs). We aimed to construct nomograms to predict survival outcomes and help to make therapeutic strategy for patients with SMPESCs.
Materials And Methods: The clinical and survival data of 135 patients with SMPESCs were analyzed retrospectively.
Article Synopsis
- - Oesophageal cancer ranks as the seventh leading cause of cancer deaths globally and has two main types: squamous cell carcinoma and adenocarcinoma, with the latter showing increasing incidence rates in recent years.
- - Advances in screening, surgical techniques, and innovative treatments have significantly improved the prognosis for oesophageal cancer, particularly for locally advanced cases treated with a combination of surgery, chemotherapy, and radiotherapy.
- - The seminar highlights recent developments in the treatment of both subtypes, emphasizing neoadjuvant therapies for advanced cancer and the establishment of immune checkpoint inhibitors as standard care in both adjuvant and first-line metastatic treatment.
Article Synopsis
- DNA is essential for life and maintaining genetic stability, with increasing focus on diseases related to DNA damage, especially in the lungs.
- * Patterns of DNA damage response are linked to chronic lung diseases such as COPD, asthma, and BPD, and studies are investigating how environmental factors contribute to this damage.
- * The article discusses factors causing lung DNA damage, diagnosis methods, repair mechanisms, and potential drug treatments to mitigate damage or enhance repair, highlighting the need for better assessment of lung DNA damage for therapeutic advancements.*
Article Synopsis
- * Current BPD management mainly uses medications and changes in ventilatory techniques, but these don't fully correct the underlying lung issues.
- * New treatments focusing on stem/progenitor cell differentiation and growth factors are crucial for improving lung development in BPD, with ongoing research highlighting their potential to restore healthy lung structure and function.
Article Synopsis
- - The study investigates the link between adverse pregnancy outcomes and cancer risk in mothers and their children, highlighting a growing concern about these health issues.
- - A systematic review of various databases identified 129 meta-analyses, finding significant associations between factors like birth weight and cancers such as breast and leukemia, with moderate certainty in the evidence.
- - The authors conclude that while there are promising connections between certain adverse pregnancy outcomes and cancer risks, further research is necessary to strengthen these associations and address potential biases.
Article Synopsis
- The study investigates the effects of Qingfei Zhisou (QFZS) oral liquid on body temperature regulation and inflammatory factors in rats induced with fever.
- Researchers established a fever model using dry yeast and divided rats into different treatment groups to assess QFZS's impact on body temperature and inflammatory proteins.
- Results indicated that QFZS effectively lowered body temperature and reduced levels of inflammatory markers, suggesting its anti-inflammatory and anti-pyrexia actions may involve the metabolism of specific lipids and regulation of ion channels related to inflammation.
Article Synopsis
- Anthracyclines are powerful chemotherapy drugs effective against various cancers, including breast cancer and lymphomas.
- Despite their effectiveness, these drugs can cause serious heart damage, which affects patient survival and quality of life.
- The paper discusses how anthracyclines work, ways to monitor heart health early, and strategies to prevent heart damage during treatment.
Rodent model of metabolic dysfunction-associated fatty liver disease: a systematic review.
J Gastroenterol Hepatol
January 2025
Article Synopsis
- * A comprehensive literature review analyzed research from 1990 to 2023 to compare physiological and metabolic traits of MASLD models with control groups, emphasizing the importance of factors like species, sex, and induction methods.
- * Future research should focus on creating reliable and reproducible models while considering environmental factors, and also explore new in vitro techniques, such as 3D models, to better understand the mechanisms of fatty liver disease.
Article Synopsis
- Neoadjuvant immunotherapy combined with chemotherapy improves outcomes for patients with resectable non-small-cell lung cancer (NSCLC), and the SACTION01 trial investigates the potential enhancement of this approach by adding stereotactic body radiotherapy (SBRT).
- In this phase 2 trial, 46 patients received SBRT followed by immunochemotherapy, resulting in a major pathological response (MPR) in 76% of participants, with some experiencing significant adverse effects, primarily alopecia and neutropenia.
- The study indicates that preoperative SBRT alongside immunochemotherapy is a viable treatment strategy, although it carries risks for severe adverse events, which need careful management.
Background: Genome instability (GI) is a hallmark of esophageal squamous cell carcinoma (ESCC) while factors affecting GI remain unclear.
Methods: Here, we aimed to characterize genomic events representing specific mechanisms of GI based on 201 ESCC samples and validated our findings at the patient, single-cell and cancer cell-line levels, including a newly generated multi-omics dataset of the trial NCT04006041.
Results: A two-gene (AHNAK and AHNAK2) mutation signature was identified to define the "AHNAK1/2-mutant" cancer subtype.
Article Synopsis
- * BPD may develop due to unusual repair responses from lung injuries that happen either before or after birth, with intrauterine inflammation identified as a key risk factor for these injuries and their connection to BPD.
- * The review explores research on how intrauterine inflammation impacts lung development, particularly the formation of alveoli and blood vessels, while also considering prenatal treatment strategies aimed at reducing this inflammation to prevent or manage BPD.
Article Synopsis
- Buyang Huanwu Decoction (BYHWD) is a traditional Chinese medicine used for treating qi deficiency and blood stasis, and the study explores its effects on platelet activation and heart function following myocardial infarction (MI).
- In an experiment on rats with induced MI, five groups were compared, including those treated with different dosages of BYHWD, to assess improvements in heart function and platelet behavior.
- Results indicated that BYHWD effectively reversed cardiac dysfunction and fibrosis, reduced platelet hyperreactivity, minimized inflammation, and showed changes in key signaling pathways related to platelet activation and heart health.
Article Synopsis
- * Whole-exome sequencing of 51 ESCC tumors before and after NCRT showed two patient groups: 13 had all pre-treatment clones disappear (clonal extinction) while 9 retained some (clonal persistence), affecting their prognosis.
- * Clone-extinct patients had more immune activity and better T cell interactions post-NCRT, while clone-persistent patients had a higher diversity of genomic mutations but worse overall outcomes.
Trends in the antimicrobial susceptibility among Chinese neonates from 2012 to 2021: a multicenter study.
Antimicrob Resist Infect Control
July 2024
Article Synopsis
- Antibiotic resistance is a significant global health problem, particularly in China, where there is limited data on antimicrobial susceptibility trends in neonates.
- A study conducted from 2012 to 2021 across 17 hospitals in China found that resistance patterns of common pathogens in full-term neonates with invasive bacterial infections varied, with some pathogens showing improved susceptibility to certain antibiotics while others worsened.
- Notably, Escherichia coli's susceptibility decreased for certain antibiotics, while group B Streptococcus and Staphylococcus aureus showed increased susceptibility, highlighting both improvements and concerns in neonatal healthcare.
Article Synopsis
- Cervical cancer is a serious type of cancer that affects the cervix, characterized by high rates of incidence and mortality, along with a tendency to spread to other parts of the body.
- Asiatic acid has shown potential in blocking cancer progression, showing effects like reduced inflammation and tumor growth, but its specific mechanisms in treating cervical cancer are not completely understood.
- Research indicates that asiatic acid can inhibit the growth and spread of cervical cancer cells and may act on the PI3K/AKT/mTOR pathway, but more studies are needed to clarify how it works.