Assessing habitat selection parameters of Arabica coffee using BWM and BCM methods based on GIS.

Arabica coffee, as one of the world's three native coffee species, requires rational planning for its growing areas to ensure ecological and sustainable agricultural development. This study aims to establish a decision-making framework using Geographic Information Systems (GIS) and Multi-Criteria Decision-Making (MCDM), with a focus on assessing the habitat suitability of Arabica coffee in Yunnan Province, China. The impacts of climate, topography, soil, and socio-economic factors were considered by selecting 13 criteria through correlation analysis.

Fractionated plasma separation and adsorption integrated with continuous veno-venous hemofiltration in patients with acute bipyridine herbicide poisoning.

Objective: To evaluate the clinical efficacy and safety of fractionated plasma separation and adsorption combined with continuous veno-venous hemofiltration (FPSA-CVVH) treatment in patients with acute bipyridine herbicide poisoning.

Methods: A retrospective analysis of 18 patients with acute bipyridine herbicide poisoning was conducted, of which 9 patients were poisoned by diquat and 9 patients by paraquat. All patients underwent FPSA-CVVH treatment.

Ultra-high sensitivity pH sensor based on vertical organic electrochemical transistors with extended gate.

An ultra-high sensitivity pH sensor based on vertical organic electrochemical transistors (vOECT) with extended gate was proposed. The vOECT, which exhibited high transconductance (g), was for the first time used in the preparation of a pH sensor. The extended gate was modified by electrochemical deposition of polyaniline (PANI) using the cyclic voltammetry (CV) technique.

Selecting Monoclonal Cell Lineages from Somatic Reprogramming Using Robotic-Based Spatial-Restricting Structured Flow.

Somatic cell reprogramming generates induced pluripotent stem cells (iPSCs), which serve as a crucial source of seed cells for personalized disease modeling and treatment in regenerative medicine. However, the process of reprogramming often causes substantial lineage manipulations, thereby increasing cellular heterogeneity. As a consequence, the process of harvesting monoclonal iPSCs is labor-intensive and leads to decreased reproducibility.

Fractionated plasma separation and adsorption integrated with continuous veno-venous hemofiltration in patients with acute liver failure: A single center experience from China.

Objective: To evaluate the clinical efficacy and safety of fractionated plasma separation and adsorption integrated with continuous veno-venous hemofiltration (FPSA-CVVH) treatment in patients with acute liver failure (ALF).

Methods: In this retrospective study, we enrolled patients with ALF (serum total bilirubin >10 mg/dL or Model for End-Stage Liver Disease [MELD] Score >18) hospitalized between August 2017 and August 2022. All patients had at least two sessions of FPSA-CVVH.

A novel efficient intramolecular self-enhanced water-soluble iridium-based electrochemiluminescence reagent and its analytical application in aptamer sensor.

In order to overcome the poor solubilities of iridium-based ECL luminophores and explore self-enhanced ECL luminophores, polyethyleneimine (PEI) covalently linked with iridium complex via amide bonds (abbreviated as Ir-PEI) as a new novel intramolecular self-enhanced water-soluble ECL reagent has been unprecedently designed and successfully synthesized in this work. The chemical structure data, FT-IR spectra, photophysical, electrochemical and electrochemiluminescence of this new ECL reagent have been well characterized. In addition, in order to investigate its properties in the real applications, a corresponding new sensitive and specific ECL-based aptasensor to monitor tetracycline (TET) residues in honey and lake water has been further constructed based on this novel self-enhanced reagent of Ir-PEI in this work.

Immunological characterization and diagnostic models of RNA N6-methyladenosine regulators in Alzheimer's disease.

Alzheimer's disease (AD) is the most prevalent form of dementia, and it displays both clinical and molecular variability. RNA N6-methyladenosine (m6A) regulators are involved in a wide range of essential cellular processes. In this study, we aimed to identify molecular signatures associated with m6A in Alzheimer's disease and use those signatures to develop a predictive model.

Non-Invasive and Label-Free On-Chip Impedance Monitoring of Heatstroke.

Heatstroke (HS) is a life-threatening injury requiring neurocritical care which could lead to central nervous system dysfunction and severe multiple organ failure syndrome. The cell-cell adhesion and cell permeability are two key factors for characterizing HS. To investigate the process of HS, a biochip-based electrical model was proposed and applied to HS.

Clinical efficacy of centrifugal-membranous hybrid double filtration plasmapheresis and membranous double filtration plasmapheresis on severe lupus nephritis.

Objective: The study delves into the clinical efficacy and safety of centrifugal-membranous hybrid double filtration plasmapheresis (C/M hybrid DFPP) on severe lupus nephritis (LN) by comparing it with membranous DFPP (M DFPP).

Methods: A retrospective cohort study was conducted in 70 patients who were diagnosed with severe LN and had received DFPP treatment.

Results: A total of 181 DFPPs were performed, including 133 C/M hybrid DFPPs (51 patients) and 48 M DFPPs (19 patients).

Single-cell sequencing reveals the immune microenvironment landscape related to anti-PD-1 resistance in metastatic colorectal cancer with high microsatellite instability.

Background: The objective response rate of microsatellite instability-high (MSI-H) metastatic colorectal cancer (mCRC) patients with first-line anti-programmed cell death protein-1 (PD-1) monotherapy is only 40-45%. Single-cell RNA sequencing (scRNA-seq) enables unbiased analysis of the full variety of cells comprising the tumor microenvironment. Thus, we used scRNA-seq to assess differences among microenvironment components between therapy-resistant and therapy-sensitive groups in MSI-H/mismatch repair-deficient (dMMR) mCRC.

Singlet Oxygen Generation via an Electrochemical Reduction Method Assisted by a Ruthenium(II) Complex.

In this work, singlet oxygen (O) is unprecedently recorded in the electrochemical reduction of tris(2,2'-bipyridine)ruthenium(II) [Ru(bpy)] in an acetonitrile solution with dissolved oxygen, which is well characterized by the specific probe of Singlet Oxygen Sensor Greens and the technique of electron-spin resonance in this work. Importantly, this new electrochemical method to produce O shows higher efficiency than the conventional photodriven method. Furthermore, taken together with the inherent advantages of electrochemical techniques compared with the photochemical/chemical-driven method, this electrochemical method would inevitably show great promise in reactive-oxygen-species-related studies in the future.

Iridium tetrazolato complexes as efficient protein staining agents.

In this work, three iridium(III) tetrazolato complexes have been designed and successfully synthesized. Beside photophysical properties, their performances in protein staining have been comprehensively investigated in this work for the first time. Notably, these iridium(III) tetrazolato complexes with high quantum efficiency exhibited much better protein staining properties than the commercial agent Coomassie Brilliant Blue (CBB) under the same experimental conditions, which may pave the way to explore new efficient iridium-based protein staining agents both for commercial markets and academic research in the future.

Synthesis and comparison study of electrochemiluminescence from mononuclear and corresponding heterodinuclear Ir-Ru complexes an amide bond as a bridge.

A mononuclear iridium-based complex with a primary amine group (named Ir-NH), a mononuclear ruthenium-based complex with a butanoic acid group (named Ru-COOH) and the corresponding heterodinuclear complex containing an iridium and ruthenium center an amide bond bridge (named Ir-Ru) were designed and successfully synthesized in this study. The photophysical and electrochemical properties and ECL performances of these three metal complexes under various experimental conditions were well characterized. For the first time, the insights from this comprehensive comparison study indicate that the two metal-based subunits with comparable luminescent properties are significant in the design of bimetallic-based multicolor luminophores at the molecular level, which helps us to further understand the emission performances of bimetallic complexes and to rationally design more efficient corresponding organometallic luminophores with multicolor emission for wide applications in the future.

Cardiac valve calcification prevalence and association with neutrophil-to-lymphocyte ratio in newly diagnosed patients with non-dialysis chronic kidney disease stage 3-5.

Objective: Cardiac valvular calcification (CVC) is the main cause of cardiovascular disease and all-cause death in patients with chronic kidney disease (CKD). However, the relationship between Neutrophil lymphocyte ratio (NLR) and CVC in patients with CKD is not clear. In this study, we aimed to investigate the prevalence of CVC in newly diagnosed patients with non-dialysis CKD stage 3-5 and evaluate the correlation between NLR and CVC.

Iridium solvent complex as a new sensitive probe to detect benzimidazole pesticides based on photoluminescent signals "switch-on" via coordination mechanism.

An iridium solvent complex (abbreviated as Ir-probe) has been synthesized and reported as a new photoluminescent "switch-on" probe to detect benzimidazole pesticides via coordination mechanism in this work. This new probe could successfully distinguish benzimidazole pesticides from other kinds of common pesticides widely used in agriculture activities. Thiabendazole (TBZ) and carbendazim (CBZ) as the representative benzimidazole pesticides, this probe exhibited good analytical performance with the linear ranges of 0.

Neoadjuvant Immunotherapy for MSI-H/dMMR Locally Advanced Colorectal Cancer: New Strategies and Unveiled Opportunities.

Patients with locally advanced colorectal cancer (LACRC) have a high risk of recurrence and metastasis, although neoadjuvant therapy may provide some benefit. However, patients with high microsatellite instability/deficient mismatch repair (MSI-H/dMMR) LACRC receive little benefit from neoadjuvant chemoradiotherapy (nCRT) or neoadjuvant chemotherapy (nCT). The 2015 KEYNOTE-016 trial identified MSI-H/dMMR as a biomarker indicative of immunotherapy efficacy, and pointed to the potential use of immune checkpoint inhibitors (ICIs).

Optimization of SPME-GC-MS and characterization of floral scents from Aquilegia japonica and A. amurensis flowers.

Background: The floral scents of plants play a key role in plant reproduction through the communication between plants and pollinators. Aquilegia as a model species for studying evolution, however, there have been few studies on the floral scents and relationships between floral scents and pollination for Aquilegia taxa.

Methods: In this study, three types of solid-phase micro-extraction (SPME) fiber coatings (DVB/PDMS, CAR/PDMS, DVB/CAR/PDMS) were evaluated for their performance in extracting volatile organic compounds (VOCs) from flowers of Aquilegia amurensis, which can contribute to the future studies of elucidating the role of floral scents in the pollination process.

suppresses proliferation and induces apoptosis of colorectal cancer cells by repressing oncogene .

Colorectal cancer (CRC), a common malignant tumor in the digestive tract, is a leading cause of cancer-related death. has been reported to act as a tumor suppressor gene in various tumors. This study aims to assess the role of SPRY4 in colorectal cancer (CRC) and uncover its underlying mechanisms.

Comparative chloroplast genomes and phylogenetic analysis of .

Premise: is an ideal taxon for studying the evolution of adaptive radiation. Current phylogenies of based on different molecular markers are inconsistent, and therefore a clear and accurate phylogeny remains uncertain. Analyzing the chloroplast genome, with its simple structure and low recombination rate, may help solve this problem.

Platelet Distribution Width and Mortality in Hemodialysis Patients.

Objectives: The association between platelet distribution width (PDW) and mortality in hemodialysis (HD) patients has received little attention.

Methods: We retrospectively enrolled HD patients in a single center from January 1, 2008, to December 30, 2011. The primary and secondary endpoints were all-cause and cardiovascular mortality, respectively.

Clinical Efficacy of Controlled-Release Morphine Tablets Combined with Celecoxib in Pain Management and the Effects on WNK1 Expression.

Objectives: This study was designed to evaluate the clinical efficacy of controlled-release morphine tablets combined with celecoxib in relieving osteocarcinoma-related pain and the effects of the combination on WNK1 expression.

Methods: A total of 110 patients with osteocarcinoma-related pain were selected and divided into two groups based on the treatment administered, including the control group (treated with controlled-release morphine tablets alone) and the study group (treated with a combination of controlled-release morphine tablets and celecoxib). We compared the treatment efficacy, pain level (visual analog scale (VAS)), time of onset of breakthrough pain (BTP), dose of morphine, incidence of adverse events, quality of life (QOL) score, and With-no-lysine 1 (WNK1) expression in the peripheral blood (PB) as determined with qRT-PCR before and after treatment, of the two groups.