Publications by authors named "Jianhong Pu"

Perinatal malnutrition is a critical cause of diseases in offspring. Based on the different rates of organ development, we hypothesised that malnutrition at varying early life stages would have a differential impact on cardiovascular disease in middle-aged and older adults. This study sought to assess the long-term impact of exposure to the 1959-1961 Great Chinese Famine (GCF) during early developmental periods on risks of cardiovascular diseases in the late middle-aged offspring.

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Article Synopsis
  • This study aimed to create and validate a machine learning model that predicts impaired fasting glucose (IFG) in middle-aged and older individuals over five years, using data from physical exams and medical histories from 1,855 participants.
  • Various machine learning algorithms, especially XGBoost, were employed, and model performance was assessed using ROC curves and SHAP plots to understand the model's insights.
  • The XGBoost model identified key factors like systolic blood pressure, fatty liver, waist circumference, and serum creatinine as significant predictors, achieving an AUC score of 0.7391, indicating its effectiveness in helping doctors identify potential IFG early.
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Background: Non-small-cell lung cancer (NSCLC) accounts for 80-85% of all lung cancer and is the leading cause of cancer-related deaths globally. Although various treatment strategies have been introduced, the 5-year survival rate of patients with NSCLC is only 20-30%. Thus, it remains necessary to study the pathogenesis of NSCLC and develop new therapeutic drugs.

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Background: Hemodialysis (HD) patients are at risk for sarcopenia (SP) and bone loss, which may impact falls and bone fragility and lead to poor prognosis. Patients with HD and those with osteoporosis (OP) are still underdiagnosed and untreated. The aims of the present study were to evaluate the factors that affect bone mineral density (BMD) loss in HD patients, and explore traditional and novel approaches to manage chronic kidney disease-mineral-bone disorder (CKD-MBD).

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Perinatal malnutrition affects postnatal cardiovascular functions. This study used the Great Chinese Famine (GCF) to determine the long-term impact of perinatal undernutrition on hypertension and arrhythmias in older offspring. Subjects ( = 10,065) were divided into an exposed group whose fetal life was in the GCF and an unexposed group.

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Article Synopsis
  • The study focuses on identifying new oncogenes related to colorectal cancer (CRC) to improve diagnosis and treatment strategies.
  • Through bioinformatics and various laboratory techniques, researchers discovered several potential biomarkers, notably the HAGHL gene, which has strong links to D-lactate levels and poor prognosis in CRC patients.
  • The findings suggest that HAGHL not only promotes cancer cell proliferation but also could serve as a valuable diagnostic tool and therapeutic target in CRC management.
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Objective: Extracranial vertebral artery dissection (EVAD) is one of the main causes of stroke in young and middle-aged patients. However, the diagnosis is challenging. This study aimed to identify the characteristics of EVAD on color duplex ultrasonography (CDU) and high-resolution magnetic resonance imaging (hrMRI), hoping to improve the accuracy and determine the relative contribution of vessel findings and clinical factors to acute ischemic events.

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Background: Gastric cancer (GC), a highly prevalent gastric cancer, has high-risk mortality. Thus, investigating strategies to counteract its growth is important to provide theoretical guidance for its prevention and treatment. It has been pointed out that abnormal expression of microRNAs (miRNAs) serves as noninvasive biomarkers for GC.

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Background: About 50 years ago, Chinese Great Famine (CGF) affected the entire population in China, and its long-term influence on the offspring has attracted significant attention for research. However, information on possible metabolic differences between sexes is limited. This study explored whether there might be sex differences in the risks of development of glucolipid metabolic dysfunction and fatty liver following prenatal exposure to CGF.

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