High-fat diets induce inflammatory IMD/NFκB signaling via gut microbiota remodeling in .

High-fat diets (HFDs), a prevailing daily dietary style worldwide, induce chronic low-grade inflammation in the central nervous system and peripheral tissues, promoting a variety of diseases including pathologies associated with neuroinflammation. However, the mechanisms linking HFDs to inflammation are not entirely clear. Here, using a HFD model, we explored the mechanism of HFD-induced inflammation in remote tissues.