Publications by authors named "Jiangyi Long"
Aims: To explore the role of chemokine CC motif ligand 2 (CCL2) in spatial memory and cognition impairment, and the underlying mechanisms focused on inflammatory, glutamate metabolistic and apoptotic- associated mRNA expression.
Materials And Methods: Stereotaxic surgery was performed here to establish a rat model by bilateral intra-hippocampal injection of CCL2. Morris water maze (MWM) and Novel object recognition test (NORT) were used to assess the learning, memory and cognitive ability respectively.
HIV-associated neurocognitive disorders (HAND) are characterized by synaptic damage and neuronal loss in the brain, ultimately leading to progressive decline of cognitive abilities and memory. Chemokine CC motif ligand 2 (CCL2) is elevated in cerebrospinal fluid (CSF), and has been believed to contribute to HAND. Previous studies by our research team have shown that CCL2 enhances N-Methyl-D-aspartate receptor (NMDAR)-mediated excitatory postsynaptic currents (EPSCs) and causes nerve cell damage.
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- CCL2 is a proinflammatory chemokine linked to cognitive impairments in HIV-1 patients, contributing to HIV-associated neurocognitive disorder (HAND).
- In a study, researchers injected CCL2 into rats to induce cognitive impairment and tested the protective effects of Tanshinone IIA, finding that it significantly improved learning and memory.
- Tanshinone IIA was shown to reduce oxidative stress, inflammation, and apoptosis in the rats' brains, suggesting its potential as a therapeutic agent for HAND.
Background: Chemokine C-C motif ligand 2 (CCL2) is one of the most widely recognised proinflammatory chemokines in cognitive disorders. Currently, CCL2-targeting drugs are extremely limited. Thus, this study aimed to explore the neuroprotection afforded by naringin in CCL2-induced cognitive impairment in rats.
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