Interventions for prevention and treatment of trastuzumab-induced cardiotoxicity: an umbrella review of systematic reviews and meta-analyses.

Background: Trastuzumab therapy for HER2-positive cancers is associated with cardiotoxicity. This umbrella review synthesizes evidence from systematic reviews and meta-analyses on cardioprotective interventions during trastuzumab treatment.

Methods: A comprehensive search was conducted in PubMed, Embase, Cochrane Library, and Web of Science.

Causal Effects of Metabolic Syndrome on Gastric Disorders: Univariable and Multivariable Mendelian Randomization.

Objectives: This study aimed to investigate the causal effects of metabolic syndrome (MetS) components, including fasting blood glucose (FBG), HDL cholesterol (HDL-C), triglycerides (TG), waist circumference (WC), and hypertension, on the risks of chronic gastritis, benign gastric tumors, and gastric cancer using Mendelian randomization (MR) analyses.

Methods: Univariable two-sample Mendelian randomization (TSMR) and multivariable Mendelian randomization (MVMR) analyses were employed to evaluate the independent and combined effects of MetS components on gastric disorders. The primary MR method used was the random effects inverse variance weighted (IVW) approach.

A ratiometric two-photon fluorescent probe for the quantification of nitroreductase in hypoxic neurons.

We developed a novel ratiometric two-photon fluorescent probe for the selective and precise detection of nitroreductase (NTR) in neurons. Using this probe, we found that hypoxic stimulation could up-regulate endogenous NTR levels.

ABO blood type is not a risk factor of outcome in aneurysmal subarachnoid hemorrhage patients.

Background: The association between ABO blood types and outcome of aneurysm subarachnoid hemorrhage (aSAH) has not reached a conclusion. This study was performed to testify the difference of outcome between ABO blood types.

Methods: 663 aSAH patients hospitalized in the West China hospital were enrolled.

Research on intelligent semi-active control algorithms and seismic reliability based on machine learning.

Aiming to address the shortcomings of existing semi-active control algorithms with poor robustness and the limited generalization ability of current evaluation methods based on deterministic analysis, a novel approach based on probability density evolution is proposed. This method is designed to assess the seismic reliability, enabling a more comprehensive evaluation of the control effectiveness of aqueduct structures. Building upon this, an intelligent semi-active control algorithm leveraging machine learning is introduced.

The relationship of nitric oxide synthase 3(NOS3) gene polymorphism in the risk of pulmonary arterial hypertension: A systematic review and meta-analysis.

Background: We performed the present study to better elucidate the correlation of nitric oxide synthase 3 (NOS3) gene polymorphism with the risk of pulmonary arterial hypertension (PAH).

Material/methods: According to the designed search strategy, a systematic literature search was performed through the PubMed, Embase, Web of Science, Cochrane Library, CNKI, VIP and Wan Fang databases to collect published case-control studies on the correlation between NOS3 gene polymorphism and PAH. The search deadline was December 26, 2023.

improves drought tolerance and increases fiber yield in cotton.

Drought poses a significant challenge to global crop productivity, necessitating innovative approaches to bolster plant resilience. Leveraging transgenic technology to bolster drought tolerance in crops emerges as a promising strategy for addressing the demands of a rapidly growing global populace. AtZAT10/STZ1, a C2H2-type zinc finger protein transcription factor has shown to significantly improve Arabidopsis' tolerance to various abiotic stresses.

Rare posterior mediastinal hemangiomas invading the spinal cord through the intervertebral foramen and causing acute symptoms: illustrative case.

Background: Hemangioma is a rare vascular tumor characterized by endothelial cell proliferation that primarily occurs in soft tissues. While most cases in the paraspinal posterior mediastinum are clinically indolent, they can also exhibit aggressive growth, leading to severe clinical outcomes and necessitating urgent treatment.

Observations: A 61-year-old right-handed female presented with reduced lower-extremity mobility that had begun 4 days earlier.

Twelve-year experience of pineal region meningiomas: long-term outcomes of maximal safe resection.

The purpose of this research was to summarize the clinical and prognostic features of pineal region meningiomas, evaluate treatment strategies and long-term prognoses, and improve the management of pineal region meningiomas. We retrospectively studied the data of 37 patients who received surgical resection for pineal region meningiomas at West China Hospital of Sichuan University from 2009 to 2021. Adjuvant gamma knife radiosurgery (GKRS) was conducted according to the extent of resection (EOR).

Administration of GUANKE alleviates SARS-CoV-2-induced pneumonia in mice.

Unlabelled: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) targets epithelial cells in the respiratory tract, triggering an acute proinflammatory response and chronic lung inflammation. Probiotic supplementation has shown promise in reducing the nasopharyngeal SARS-CoV-2 viral load, diminishing symptom frequency and duration, and mitigating inflammation; thus, it is a potential strategy for treating coronavirus disease 2019 (COVID-19), which is caused by SARS-CoV-2 infection. In this study, we evaluated the effects of the oral administration of the GUANKE strain, a gram-positive bacterium originally isolated from a healthy individual, on SARS-CoV-2 infection in a human ACE2 transgenic mouse model.

A fundus vessel segmentation method based on double skip connections combined with deep supervision.

Background: Fundus vessel segmentation is vital for diagnosing ophthalmic diseases like central serous chorioretinopathy (CSC), diabetic retinopathy, and glaucoma. Accurate segmentation provides crucial vessel morphology details, aiding the early detection and intervention of ophthalmic diseases. However, current algorithms struggle with fine vessel segmentation and maintaining sensitivity in complex regions.

The Punicalagin Compound Mitigates Bronchial Epithelial Cell Senescence Induced by Cigarette Smoke Extract through the PAR2/mTOR Pathway.

Background: Tobacco smoke is an important inducer of airway epithelial cell aging. Punicalagin(PCG) is a natural anti-aging compound. The effect of PCG on tobacco smoke-induced airway epithelial cell senescence is unknown.

sp. nov., and sp. nov., two new members of the genus isolated from plateau pika ().

Four anaerobic, Gram-stain-positive, non-motile, non-sporulating rod-shaped bacterial strains (R7, R21, R22 and R25) were isolated from the intestinal contents of plateau pika () collected from the Qinghai-Tibet Plateau, PR China. The four isolates grew at between 25 and 42 °C (optimally at 35-37 °C), and with 0.3-3.