Publications by authors named "Jianguo Ma"

Background: Gastrointestinal bleeding is a serious adverse event of coronary artery bypass grafting and lacks tailored risk assessment tools for personalized prevention.

Objective: This study aims to develop and validate predictive models to assess the risk of gastrointestinal bleeding after coronary artery bypass grafting (GIBCG) and to guide personalized prevention.

Methods: Participants were recruited from 4 medical centers, including a prospective cohort and the Medical Information Mart for Intensive Care IV (MIMIC-IV) database.

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Purpose: To assess the value of secondary lesion-targeted biopsy (SLx) in detecting prostate cancer (PCa) among patients with multifocal disease.

Methods: A total of 298 biopsy-naïve patients with 612 lesions (all with Prostate Imaging Reporting and Data System [PI-RADS] v2.1 ≥ 3) underwent cognitive fusion-targeted biopsy (TB) combined with systematic biopsy (SB).

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Purpose: The purpose of this study was to evaluate the nature of ultrasound characteristics during mpMRI/TRUS cognitive fusion targeted biopsy (cTB).

Methods: From 2023 to 2024, data from 502 lesions in 426 men who underwent targeted combined systematic biopsy were analyzed. All lesions had a Prostate Imaging Reporting and Data System (PI-RADS) score of ≥ 3.

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Computer-aided segmentation of medical ultrasound images assists in medical diagnosis, promoting accuracy and reducing the burden of sonographers. However, the existing ultrasonic intelligent segmentation models are mainly based on B-mode grayscale images, which lack sufficient clarity and contrast compared to natural images. Previous research has indicated that ultrasound radiofrequency (RF) signals contain rich spectral information that could be beneficial for tissue recognition but is lost in grayscale images.

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  • The study aimed to explore how Anti-ganglioside GM1 antibodies (Anti-GM1) affect the natural killer (NK) cells' ability to kill cancer cells in nude mice by altering their differentiation.
  • Researchers used a detailed staining method to identify NK cell characteristics in kidney cancer tissues and immunized mice with GM1 to produce Anti-GM1.
  • The results showed that Anti-GM1 significantly reduced NK cell activity, promoted their maturation, and decreased key signaling molecules (IFN-γ and GzmB) involved in their killing function compared to a control group.
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For a long time, intercropping and rotation of leguminous with non-leguminous crops is widely used to reduce the application of nitrogen fertilizer and increase yield in agroecosystems. At present, most researchers considered that this management measure is helpful for reducing fertilizer consumption and increasing its efficiency, as it can improve nutrient supply of legumestonon-legumes, the spatial nutrient utilization efficiency by enhancing soil spatial heterogeneity, and improve soil structure and disease resistance. However, current theories cannot fully explain the positive effect of crop rotation and inter-cropping systems involving legumes.

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Despite the continuous developments and advancements in the treatment of gastric cancer (GC), which is one of the most prevalent types of cancer in China, the overall survival is still poor for most patients with advanced GC. In recent years, with the progress in tumor immunology research, attention has shifted toward immunotherapy as a therapeutic approach for GC. Programmed cell death protein 1 (PD-1) inhibitors, as novel immunosuppressive medications, have been widely utilized in the treatment of GC.

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Objectives: To explore the clinical value of the nomogram based on spectral Doppler ultrasound combined with clinical pathological parameter in predicting axillary lymph node metastasis in breast cancer.

Methods: We prospectively gathered clinicopathologic and ultrasonic data from 240 patients confirmed breast cancer. The risk factors of axillary lymph node metastasis were analyzed by univariate and multivariate logistic regression, and the prediction model was established.

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  • A newly identified polyphagous pest is currently only found in Asia but threatens major crops like maize and cotton.
  • Research indicates that this pest is actually a single species, raising concerns over its potential global spread.
  • Using climate data, the study predicts a suitable habitat expansion for this pest by the 2070s, highlighting the need for effective monitoring and control strategies to protect agricultural production worldwide.
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Early ultrasound screening for breast cancer reduces mortality significantly. The main evaluation criterion for breast ultrasound screening is the Breast Imaging-Reporting and Data System (BI-RADS), which categorizes breast lesions into categories 0-6 based on ultrasound grayscale images. Due to the limitations of ultrasound grayscale imaging, lesions with categories 4 and 5 necessitate additional biopsy for the confirmation of benign or malignant status.

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Traditional brightness-mode ultrasound imaging is primarily constrained by the low specificity among tissues and the inconsistency among sonographers. The major cause is the imaging method that represents the amplitude of echoes as brightness and ignores other detailed information, leaving sonographers to interpret based on organ contours that depend highly on specific imaging planes. Other ultrasound imaging modalities, color Doppler imaging or shear wave elastography, overlay motion or stiffness information to brightness-mode images.

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Introduction: Grassland-livestock balance is an important principle of sustainable development of grassland livestock production and grassland ecosystem health. Grassland degradation becomes more serious at global scales and especially at the area that is sensitive to climate change and human activities. Decreases in pasture biomass and shifts in plant community composition in degraded grasslands can largely affect grazing behaviors of livestock.

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An air spring (AS) for ships must have the structural strength of its bellows enhanced considerably to ensure its reliability under high internal pressure and strong impact. In this case, the stiffness of the bellows gradually dominates the overall stiffness of the AS. Nevertheless, the parameterization calculation of stiffness for an AS mainly focuses on its pneumatic stiffness.

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Objective: This study aimed to develop and evaluate machine-learning models for predicting the onset of overweight in adolescents aged 14‒17, utilizing easily collectible personal information.

Methods: This study was a one-year prospective cohort study. Baseline data were collected through anthropometric measurements and questionnaires, and the incidence of overweight was calculated one year later via anthropometric measurements.

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  • Bladder cancer is increasing in prevalence and mortality rates, but the specific role of RAC3 in cisplatin-resistant bladder cancer cells is not fully understood.
  • Using bioinformatics and lab techniques, researchers examined RAC3 expression in bladder cancer tissues, its correlation with cancer characteristics, and its impact on the immune environment and cell signaling pathways.
  • Results showed higher levels of RAC3 in bladder cancer tissues linked to poor outcomes, with RAC3 overexpression promoting growth and resistance in cisplatin-resistant cells, while silencing it slowed their growth.
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Purpose: Accurate segmentation of the endometrium in ultrasound images is essential for gynecological diagnostics and treatment planning. Manual segmentation methods are time-consuming and subjective, prompting the exploration of automated solutions. We introduce "segment anything with inception module" (SAIM), a specialized adaptation of the segment anything model, tailored specifically for the segmentation of endometrium structures in ultrasound images.

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The elimination of uranium from radioactive wastewater is crucial for the safe management and operation of environmental remediation. Here, we present a layered vanadate with high acid/base stability, [MeNH]VO, as an excellent ion exchanger capturing uranyl from highly complex aqueous solutions. The material possesses an indirect band gap, ferromagnetic characteristic and a flower-like morphology comprising parallel nanosheets.

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  • The trait-based unidimensional plant economics spectrum offers insight into how plants adapt to their environments, but there's still uncertainty about the complex relationships between leaf and root traits influenced by environmental factors and microbial strategies.
  • This study analyzed the relationships between pairs of leaf and fine root traits in alpine meadow plants, revealing two main dimensions: collaboration gradient, which balances lifespan and resource efficiency, and conservation gradient, focusing on resource uptake strategies.
  • It was found that climatic factors primarily drive these traits, with strong connections to soil microbial strategies, suggesting that both leaf and root traits are part of a multidimensional adaptation strategy to their environments that also involves microbial interactions.
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Large floating raft vibration isolation systems (FRVISs) based on high-static-low-dynamic stiffness (HSLDS) technology offer excellent low frequency vibration isolation performance with broad application prospects. However, the design process for these complex high-dimensional coupled nonlinear systems remains poorly developed, particularly when applied for ocean-going vessels that experience rolling and pitching motions. The present work addresses this issue by establishing a six-degree-of-freedom HSLDS vibration isolation model for FRVISs composed of eight isolators, and the model is applied to fully analyze the swing stability and multidimensional vibration isolation performance of these systems.

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Herein, a magnetic bead-based chemiluminescence assay is reported to detect type IV collagen (col-IV) in serum samples. Magnetic beads (MBs) exhibit biocompatibility. Taking advantage of this property, they were conjugated with the col-IV antibody.

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Aims: To explore the effect of blocking galectin-3 in the bladder pain syndrome associated with interstitial cystitis.

Methods: A galectin-3 inhibitor was used to treat mice with cyclophosphamide-induced cystitis. The expression of galectin-3 in bladder tissues and urine was examined by immunohistochemistry and enzyme-linked immunosorbent assay (ELISA), respectively.

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Breast cancer has become the most common cancer worldwide, and early screening improves the patient's survival rate significantly. Although pathology with needle-based biopsy is the gold standard for breast cancer diagnosis, it is invasive, painful, and expensive. Meanwhile it makes patients suffer from misplacement of the needle, resulting in misdiagnosis and further assessment.

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  • TL-895 is a potent and selective second-generation drug that irreversibly inhibits Bruton's tyrosine kinase (BTK), showing strong potential in treating B-cell lymphomas.
  • The drug was assessed for its effectiveness in various models, demonstrating significant inhibition of BTK activity, auto-phosphorylation, and tumor growth in multiple types of lymphoma cells and xenograft models.
  • Despite some effects on antibody-dependent cell-mediated cytotoxicity, TL-895 proved to be mainly effective at higher exposure levels, indicating its promising role in B-cell lymphoma treatment.
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Soil heavy metal contamination and salinity constitute a major environmental problem worldwide. The affected area and impact of these problems are increasing day by day; therefore, it is imperative to restore their potential using environmentally friendly technology. Plant growth-promoting rhizobacteria (PGPR) provides a better option in this context.

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  • - This study investigated how combining total prostate-specific antigen (TPSA) with other laboratory indicators can enhance the diagnosis of prostate cancer (PCa).
  • - Researchers analyzed data from 291 patients who had prostate biopsies, comparing those with benign prostatic hyperplasia to those with PCa, and further categorized them based on their TPSA levels.
  • - The results showed that combining TPSA with additional metrics led to better diagnostic accuracy, particularly for patients with higher TPSA levels (>10 ng/mL).
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