Optimization of Plasma Welding Sequence and Performance Verification for a Fork Shaft: A Comparison of Same-Direction and Reverse-Direction Welding.

The shift fork shaft is a key component in transmissions, connecting the shift fork in order to adjust the gear engagement. This study investigates the effects of different welding sequences on deformation and residual stress during plasma welding of the shift fork shaft. A temperature-displacement coupled finite element method, using ABAQUS simulation software and a double ellipsoid heat source model, was employed for the numerical analysis.

Evaluation of a biomarker (NO) dynamics in inflammatory zebrafish and periodontitis saliva samples via a fast-response and sensitive fluorescent probe.

Many pathological processes include nitric oxide (NO), a signaling transduction molecule. Tumors, cardiovascular, cerebrovascular, neurodegenerative, and other illnesses are linked to abnormal NO levels. Thus, evaluating NO levels in vitro and in vivo is crucial for studying chemical biology process of associated disorders.

Pharmacokinetics of 4-Hydroxybenzaldehyde in Normal and Cerebral Ischemia-Reperfusion Injury Rats Based on Microdialysis Technique.

Aim: 4-Hydroxybenzaldehyde (4-HBd) is used for the treatment of headaches, dizziness, and convulsions. The objective of this study was to characterize the pharmacokinetics of 4-HBd in cerebral ischemia-reperfusion injury (CIRI) rats by microdialysis technology with high-performance liquid chromatography with diode-array detection (HPLC-DAD) and ultra-performance liquid chromatography-mass spectrometry (UPLC-MS).

Methods: Microdialysis was used to collect blood, feces, and urine of normal and CIRI model rats.

Stable Loading and Delivery of Icaritin Using PEG-PCL Micelles for Effective Treatment of Oral Squamous Cell Carcinoma.

Background: Icaritin can inhibit cell proliferation and induce apoptosis in Oral Squamous Cell Carcinoma (OSCC). However, low solubility limits its clinical usage.

Objectives: To improve the efficacy of icaritin treatment, a micelle system was designed for targeted delivery of drugs to OSCC cells.

Reduced glutathione does not further reduce contrast-induced nephropathy in elderly patients with diabetes receiving percutaneous coronary intervention.

Objective: To investigate the preventive effect of hydration combined with reduced glutathione on contrast-induced nephropathy (CIN) after coronary intervention therapy in elderly Chinese patients with diabetes.

Methods: Patients with diabetes aged ≥65 years, who received percutaneous coronary intervention (PCI) between 1 August 2016 and 31 December 2018, were enrolled and randomized into two groups: patients treated with hydration combined with reduced glutathione (treatment group) and patients who received hydration alone (controls). Serum creatinine and creatinine clearance levels were measured in all patients before PCI and then daily for 3 days after PCI.

Targeting CD47 Inhibits Tumor Development and Increases Phagocytosis in Oral Squamous Cell Carcinoma.

Background: Our previous work demonstrated upregulated CD47 in Oral Squamous Cell Carcinoma (OSCC).

Objective: In the present study, we aimed to investigate the effects of CD47 on tumor cell development and phagocytosis in OSCC and elucidate the underlying mechanisms.

Methods: The proliferation, apoptosis, migration, and invasion of oral cancer cells were analyzed after knocking down the expression of CD47.

A case of simultaneous acute cardio-cerebral infarction in a woman with essential thrombocythemia.

Essential thrombocythemia (ET) can cause arterial embolism. Patients with arterial thrombosis usually have additional risk factors, such as smoking and hypertension. We report a 70-year-old woman with ET who had no risk factors, except for age.

Acute myocardial infarction in pregnancy: spasm caused by hyperthyroidism?

We present a 26-year-old woman with ST-segment elevation myocardial infarction in the 14th week of pregnancy. Coronary angiography revealed no abnormalities in the coronary arteries. She had no history of coronary risk factors such as smoking, diabetes mellitus, hypertension, or dyslipidemia.

Osthole protects against Ang II-induced endotheliocyte death by targeting NF-κB pathway and Keap-1/Nrf2 pathway.

Osthole, the main active constituents in traditional Chinese medicine fructus cnidii, has anti-inflammatory and anti-oxidant activities. Apoptosis of vascular endothelial cells is an important cause of cardiovascular disease. Inflammation and oxidative stress are two key factors in injury of endotheliocyte.

Co-Delivery of Rose Bengal and Doxorubicin Nanoparticles for Combination Photodynamic and Chemo-Therapy.

Carboxymethyl chitosan (CMCS) is applied as a nanodelivery system carrier for sustained intracellular release of rose bengal (RB) and doxorubicin (DOX) to achieve combinational drug treatments. An integral analytical method was used to characterize the structure of CMCS-RB, the amount of RB and DOX, the average particle size, the zeta potential, and the morphology, including Fourier transform infrared (FTIR), nuclear magnetic resonance (H NMR), ultraviolet visible spectroscopy (UV-Vis), scanning electron microscope (SEM), laser particle size analyzer and transmission electron microscopy (TEM). The results revealed that the maximum encapsulation efficiency and loading capacity of DOX into the CMCS-RB-DOX nanoparticles was 13.

Electrochemical mechanism of tin membrane electrodeposition under ultrasonic waves.

Tin was electrodeposited from chloride solutions using a membrane cell under ultrasonic waves. Cyclic voltammetry (CV), linear sweep voltammetry (LSV), chronoamperometry (CHR), and chronopotentiometry were applied to investigate the electrochemical mechanism of tin electrodeposition under ultrasonic field. Chronoamperometry curves showed that the initial process of tin electrodeposition followed the diffusion controlled three-dimensional nucleation and grain growth mechanism.

Ischemic stroke in patients with POEMS syndrome: a case report and comprehensive analysis of literature.

Background: POEMS syndrome is a rare multi-systemic disease characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes. Arterial or venous thrombosis is a less-common complication of POEMS syndrome. Ischemic stroke has also been reported sporadically.

Perimesencephalic nonaneurysmal subarachnoid hemorrhage caused by transverse sinus thrombosis: A case report and review of literature.

Rationale: Perimesencephalic nonaneurysmal subarachnoid hemorrhage (PNSAH) is characterized by a pattern of extravasated blood restricted to the perimesencephalic cisterns, normal angiographic findings, and an excellent prognosis with an uneventful course and low risks of complication. The precise etiology of bleeding in patients with PNSAH has not yet been established. The most common hypothesis is that PNSAH is venous in origin.

Icaritin Reduces Oral Squamous Cell Carcinoma Progression via the Inhibition of STAT3 Signaling.

Icaritin, a traditional Chinese medicine, possesses antitumor activity. The current study aimed to investigate icaritin effect and potential mechanism on oral squamous cell carcinoma (OSCC) development. OSCC cells proliferation, apoptosis, and autophagy were analyzed after incubation with icaritin at different concentrations and incubation times.

Different Expression of MicroRNA-146a in Peripheral Blood CD4(+) T Cells and Lesions of Oral Lichen Planus.

Oral lichen planus (OLP) is a common T cell-mediated chronic inflammatory disease of unknown etiology. Recent increasing evidence indicates that microRNA-146a (miR-146a) plays a vital role in inflammatory diseases and T cell regulation. This study aimed to investigate the expression of miRNA-146a in peripheral blood CD4(+) T cells and local OLP lesions and to evaluate its relationship with clinical forms of OLP.

A new membrane electro-deposition based process for tin recovery from waste printed circuit boards.

The current research investigated a process combining leaching, purification and membrane electrodeposition to recover tin from the metal components of WPCBs. Experimental results showed that with a solid liquid ratio of 1:4, applying 1.1 times of stoichiometric SnCl4 dosage and HCl concentration of 3.

Iron-deficiency anemia: a predictor of diminished disease-free survival of T3N0M0 stage colon cancer.

Purpose: The aim of this study was to determine whether iron-deficiency anemia (IDA) predicts long-term oncologic outcomes in patients with TNM stage II colon cancer.

Methods: Clinical and follow-up data were extracted from a prospective colon cancer database. Univariate and multivariate analyses were performed to identify IDA and other predictors of long-term oncologic outcomes.

Expression of T-bet and GATA-3 in peripheral blood mononuclear cells of patients with oral lichen planus.

Objective: Oral lichen planus (OLP) is a T-cell-mediated chronic inflammatory oral disease of unknown aetiology. Imbalanced cytokine production by Th1 and Th2 probably contributes to the pathogenesis of OLP. Growing evidence has suggested that two Th1/Th2-specific transcription factors, T-bet and GATA-3, may play a critical role in the development of Th1 and Th2 immunity.

Heavy metal removal and crude bio-oil upgrading from Sedum plumbizincicola harvest using hydrothermal upgrading process.

The main aim of this study was to separate heavy metals and yield crude bio-oil from a heavy metals hyperaccumulator harvest, Sedum plumbizincicola, through hydrothermal upgrading process. Parameters such as granularity, temperature, pressure, and duration were examined for their effect on the removal efficiency of heavy metals and upgrading efficacy of crude bio-oil. Maximum heavy metal removal efficiency of >99% and crude bio-oil upgrading efficiency of >63% were attained with an 18 mesh (1 mm) granularity, and 22.

Heavy metal removal and crude bio-oil upgrading from Sedum plumbizincicola harvest using hydrothermal upgrading process.

The main aim of this study was to separate heavy metals and yield crude bio-oil from a heavy metals hyperaccumulator harvest, Sedum plumbizincicola, through hydrothermal upgrading process. Parameters such as granularity, temperature, pressure, and duration were examined for their effect on the removal efficiency of heavy metals and upgrading efficacy of crude bio-oil. Maximum heavy metal removal efficiency of >99% and crude bio-oil upgrading efficiency of >63% were attained with an 18 mesh (1mm) granularity, and 22.

Heavy metal removal and crude bio-oil upgrade from Sedum alfredii Hance harvest using hydrothermal upgrading.

In this study, heavy metals were removed and crude bio-oil was yielded from a heavy metal hyperaccumulator harvest, Sedum alfredii Hance, through hydrothermal upgrading process. This paper reports on the optimization of process parameters for the removal of heavy metals (zinc, lead, and copper) and for the upgrading of crude bio-oil from this biomass in an autoclave. Parameters such as granularity, temperature, pressure, and duration were examined for their effect on the removal efficiency of heavy metals and upgrading efficacy of crude bio-oil.

Recovery of zinc from hyperaccumulator plants: Sedum plumbizincicola.

Hyperaccumulator biomass harvested after heavy-metal phytoremediation must be considered as hazardous waste that should be contained or treated appropriately before disposal or reuse. As a potential method to detoxify the biomass and to convert this material to a suitable fertilizer or mulch, leaching of heavy metals from Sedum plumbizincicola biomass was studied by using ammonia-ammonium chloride solution as a leaching agent. The research was carried out in two phases: (i) a leaching study to determine the heavy metal:zinc extraction efficiency of this leaching agent and (ii) a thermodynamic analysis to identify the likely reactions and stable Zn(II) species formed in the leaching systems.