Publications by authors named "Jiangting Li"

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  • The switch from oxidative phosphorylation to glycolysis is essential for activating microglia, particularly in the context of Parkinson's disease (PD).
  • Recent research shows that inhibiting glycolysis can reduce inflammation and protect dopaminergic neurons in PD mice by decreasing lactate levels.
  • The study identifies a significant role of histone lactylation, specifically H3K9, in promoting microglial activation, suggesting potential therapeutic avenues for managing neuroinflammation in PD.
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Optical metrology is a well-established subject, dating back to early interferometry techniques utilizing light's linear momentum through fringes. In recent years, significant interest has arisen in using vortex light with orbital angular momentum (OAM), where the phase twists around a singular vortex in space or time. This has expanded metrology's boundaries to encompass highly sensitive chiral interactions between light and matter, three-dimensional motion detection via linear and rotational Doppler effects, and modal approaches surpassing the resolution limit for improved profiling and quantification.

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  • Gallium nitride (GaN) is a promising semiconductor for biomedical devices due to its excellent photoelectric properties, chemical stability, and biocompatibility, allowing it to interact with biological components.
  • Research demonstrated that exposing neural stem cells (NSCs) to GaN with ultraviolet (UV) irradiation promotes their differentiation into neurons, as evidenced by increased neuron formation and enhanced expression of neuron-related markers.
  • Experiments indicated that NSCs cultured on GaN with UV irradiation had a higher cell membrane potential, potentially due to the presence of more photogenerated free charge carriers, supporting GaN's use in future biomedical applications.
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Hepatocellular carcinoma (HCC) is a highly prevalent cancer with a significant impact on human health. Curcumin, a natural compound, induces cytoskeletal changes in liver cancer cells and modifies the distribution of lipids, proteins, and polysaccharides on plasma membranes, affecting their mechanical and electrical properties. In this study, we used nanomechanical indentation techniques and Kelvin probe force microscopy (KPFM) based on atomic force microscopy (AFM) to investigate the changes in surface nanomechanical and electrical properties of nuclear and cytoplasmic regions of HepG2 cells in response to increasing curcumin concentrations.

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Fast increased amount of excess activated sludge (EAS) from wastewater treatment plants has aroused universal concerns on its environmental risks and demands for appropriate treatments, while effective treatment is dependent upon proper pretreatment. In this study, air-supplied microbubbles (air-MBs) with generated size of 25.18 to 28.

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  • Parkinson's disease (PD) is linked to lost dopaminergic neurons and neuroinflammation, with microRNA-218-5p potentially playing a role in its progression.
  • In a study using a mouse model of PD, overexpressing miR-218-5p reduced neuroinflammation, protected DA neurons, and improved motor function, suggesting its protective effects against PD pathology.
  • Additionally, experiments indicated that miR-218-5p targets the gene Ddx41 and modulates type I interferon pathways, highlighting its regulatory role in neuroinflammation related to PD.
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  • CCL5 is linked to the progression of Parkinson's disease by promoting Th17 cell differentiation and increasing their infiltration into the substantia nigra (SN), which is critical for dopamine neuron survival.
  • The study shows that CCL5 enhances LFA-1 expression on Th17 cells and that this process is mediated by activating tyrosine kinases LCK and ZAP70 in naive CD4 T cells.
  • Inhibiting these kinases significantly reduces Th17 cell numbers and LFA-1 expression, suggesting potential therapeutic targets for mitigating dopamine neuron loss in Parkinson's disease.
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  • - The study investigates the connection between kidney function (measured primarily through eGFR) and cognitive impairment in Parkinson's disease patients, highlighting that this relationship is not well understood.
  • - Findings reveal that lower eGFR is linked to increased risk of cognitive decline and may predict changes in key biomarkers related to neurodegeneration.
  • - The research indicates that monitoring eGFR could help identify Parkinson’s patients at risk of rapid cognitive decline and may have implications for future treatment strategies.
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  • Apathy is a common and challenging symptom in Parkinson's disease (PD), with a study suggesting that abnormal iron metabolism may be linked to it.
  • Researchers analyzed data from 201 PD patients, using assessments like the Apathy Scale (AS) and serum iron levels to find correlations, particularly in male participants.
  • A nomogram was created to predict apathy based on five parameters, showing good accuracy and indicating that factors like total iron binding capacity (TIBC) and depression scores are useful for identifying apathetic PD patients.
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  • Neuroinflammation is linked to Parkinson's disease (PD), with multiple studies analyzing inflammatory markers in blood and cerebrospinal fluid (CSF) of PD patients compared to controls.
  • Data from 152 studies showed increased levels of several inflammatory markers (like IL-6 and TNF-α) and decreased levels of others (like INF-γ) in the PD group, indicating significant inflammation associated with the disease.
  • The findings confirm that PD involves altered inflammatory responses both in peripheral blood and CSF, supporting the theory of neuroinflammation's role in PD pathogenesis.
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  • Parkinson's disease (PD) is linked to an imbalance of immune cells, specifically an increase in Th17 cells and a decrease in regulatory T cells (Tregs), which is correlated with the loss of dopaminergic neurons and motor symptoms in patients.
  • Research showed that the presence of alpha-Synuclein (α-Syn) drives changes in Tregs, leading to their dysfunction and promoting Th17 cell differentiation, which further contributes to the pathology of PD.
  • Inhibiting the transcription factor RORγt can counteract the adverse effects caused by α-Syn stimulation, suggesting a potential therapeutic target for restoring immune balance and protecting dopaminergic neurons in PD.
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  • FOG (Freezing of gait) is linked to worse cognitive performance in individuals with Parkinson's disease, indicating that those experiencing FOG are more likely to have cognitive impairments compared to those without.
  • Patients who exhibited progressive FOG over time showed greater cognitive declines, suggesting a significant relationship between worsening gait and cognitive function.
  • The study highlights the importance of monitoring cognitive changes and developing specific interventions for Parkinson's patients who experience FOG to help address cognitive impairments early.
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  • The study investigates the role of soluble TREM2 (sTREM2) in cerebrospinal fluid (CSF) as a potential biomarker for cognitive decline in Parkinson's disease (PD), finding it is elevated in cases of cognitive decline but not distinctly different between PD patients and healthy individuals.
  • Analysis of 219 PD patients showed that higher baseline levels of sTREM2 correlate with an increased risk of cognitive decline over time, particularly in certain subgroups based on CSF pathology.
  • The findings suggest sTREM2 may be useful for monitoring neuronal injury and microglial activity in PD but are less effective as a direct diagnostic marker.
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  • Sleep disorders are common and significantly impact patients with Parkinson's disease (PD), affecting both motor and non-motor symptoms.
  • Researchers studied 328 participants using sleep quality assessments and various analyses to explore these associations.
  • The findings revealed that poor sleep correlates with more severe PD symptoms, with specific sleep durations linked to increased non-motor symptom burdens, highlighting the need for better sleep management in PD treatment.
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Orbital angular momentum (OAM) mode crosstalk induced by atmospheric turbulence is a challenging phenomenon commonly occurring in OAM-based free-space optical (FSO) communication. Recent advances have facilitated new practicable methods using abruptly autofocusing light beams for weakening the turbulence effect on the FSO link. In this work, we show that a circular phase-locked Airy vortex beam array (AVBA) with sufficient elements has the inherent ability to form an abruptly autofocusing light beam carrying OAM, and its focusing properties can be controlled on demand by adjusting the topological charge values and locations of these vortices embedded in the array elements.

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We introduce an alternative distribution to the gamma-gamma (GG) distribution, called inverse Gaussian gamma (IGG) distribution, which can efficiently describe moderate-to-strong irradiance fluctuations. The proposed stochastic model is based on a modulation process between small- and large-scale irradiance fluctuations, which are modeled by gamma and inverse Gaussian distributions, respectively. The model parameters of the IGG distribution are directly related to atmospheric parameters.

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Based on the complex-source-point method and the generalized Lorenz-Mie theory, the scattering properties and polarization of aerosol particles by a Hermite-Gaussian (HG) beam in marine atmosphere is investigated. The influences of beam mode, beam width, and humidity on the scattered field are analyzed numerically. Results indicate that when the number of HG beam modes u (v) increase, the radar cross section of aerosol particles alternating appears at maximum and minimum values in the forward and backward scattering, respectively, because of the special petal-shaped distribution of the HG beam.

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The probability densities of orbital angular momentum (OAM) modes of the autofocusing Airy beam (AAB) carrying power-exponent-phase vortex (PEPV) after passing through the weak anisotropic non-Kolmogorov turbulent atmosphere are theoretically formulated. It is found that the AAB carrying PEPV is the result of the weighted superposition of multiple OAM modes at differing positions within the beam cross-section, and the mutual crosstalk among different OAM modes will compensate the distortion of each OAM mode and be helpful for boosting the anti-jamming performance of the communication link. Based on numerical calculations, the role of the wavelength, waist width, topological charge and power order of PEPV in the probability density distribution variations of OAM modes of the AAB carrying PEPV is explored.

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Background: Sodium copper chlorophyllin (SCC), as one of the derivatives of chlorophyll - with its inherent green features; good stability for heat, light, acids and alkalies; unique antimicrobial capability; and particular deodori zation performance - is widely applied in some fields such as the food industry, medicine and health care, daily cosmetic industry etc. SCC, as one of the metal porphyrins, has attracted much attention because of its unique electronic band structure and photon conversion performance. To promote the application of SCC in materials science; energy research and photonics, such as fast optical communications; and its use in nonlinear optical materials, solar photovoltaic cells, all-optical switches, optical limiters and saturable absorbers, great efforts should be dedicated to studying its nonlinear optical (NLO) properties.

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An anisotropic power spectrum of the refractive-index fluctuation in hypersonic turbulence was obtained by processing the experimental image of the hypersonic plasma sheath and transforming the generalized anisotropic von Kármán spectrum. The power spectrum suggested here can provide as good a fit to measured spectrum data for hypersonic turbulence as that recorded from the nano-planar laser scattering image. Based on the newfound anisotropic hypersonic turbulence power spectrum, Rytov approximation was employed to establish the wave structure function and the spatial coherence radius model of electromagnetic beam propagation in hypersonic turbulence.

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Rytov theory was employed to establish the transmission model for the optical vortices carried by Bessel-Gaussian (BG) beams in weak anisotropic turbulence based on the generalized anisotropic von Karman spectrum. The influences of asymmetry anisotropic turbulence eddies and source parameters on the signal orbital angular momentum (OAM) mode detection probability of partially coherent BG beams in anisotropic turbulence were discussed. Anisotropic characteristics of the turbulence could enhance the OAM mode transmission performance.

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The analytical formulas for the orbital angular momentum (OAM) mode probability density, signal OAM mode detection probability, and spiral spectrum of partially coherent Laguerre-Gaussian (LG) beams with optical vortices propagation in weak horizontal oceanic turbulent channels were developed, based on the Rytov approximation theory. The effect of oceanic turbulence and beam source parameters on the propagation behavior of the optical vortices carried by partially coherent LG beams was investigated in detail. Our results indicated that optical turbulence in an ocean environment produced a much stronger effect on the optical vortex than that in an atmosphere environment; the effective range of the signal OAM mode of LG beams with a smaller ratio of the mode crosstalk was limited to only several tens of meters in turbulent ocean.

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We demonstrated an asymmetric 1,3-dipolar cycloaddition of azomethine betaines with alkylidene malonates by using a chiral N,N'-dioxide-Ni(II) complex as a catalyst. Both aromatic- and aliphatic-substituted alkylidene malonates were found to be suitable for the reaction. A range of trans-pyrazolone derivatives was exclusively obtained with excellent yields (up to 99% yield) and good enantioselectivities (up to 97% ee) under mild reaction conditions.

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