Design, synthesis and antibacterial activity of novel 7-thiazolo[3,2-]-1,2,4-triazin-7-one derivatives.

Based on the observed biological activity of 1,2,4-triazin-5-one derivatives and their cyclic analogues, a novel series of 7-thiazolo[3,2-]-1,2,4-triazin-7-one derivatives that contain ester moiety compounds carboxylic acid moiety compounds and piperazine amide moiety compounds at position-3 of the thiazolotriazinone scaffold were synthesized. The intermolecular cyclization occurred regioselectively at N2-position of 1,2,4-triazine ring was characterized by X-ray single-crystal diffraction analysis. The biological activities of the target compounds were assayed against some bacterial strains.