Clinical value of CD3CD56 natural killer cells, IL-2, and IL-8 in acute exacerbation of chronic obstructive pulmonary disease in patients with respiratory failure.

Objective: This study aims to investigate the the content of CD3CD56 Natural Killer (NK) cells in peripheral blood and the serum interleukin-2 (IL-2) and interleukin-8 (IL-8) levels in patients with acute exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD) complicated by respiratory failure (RF). Besides, their diagnostic and prognostic values for AECOPD combined with RF were also explored.

Methods: This retrospective study included patients from the Affiliated Jiangning Hospital of Nanjing Medical University between December 2021 and December 2023.

Cryptococcus albidus infected pulmonary mycosis with miliary nodules in CT imaging: Two case reports.

We presented two cases of Cryptococcus albidus fungemia in men who were identified with millary nodules by chest computed tomography (CT). They present cough and fever, with no other abnormal physical examination. The patients were treated successfully with a week-long course of voriconazole tablets.

CircUBR1 knockdown relieves ventilator-induced lung injury through regulating miR-20a-5p/GGPPS1 pathway.

Objective: To assess the influences and underlying mechanism of circular RNA UBR1 (circUBR1) in ventilator-induced lung injury (VILI).

Methods: In mice and mouse alveolar epithelial cells, VILI model was established. CircUBR1 and miR-20a-5p expression was assessed via quantitative real time polymerase chain reaction.

Surface anchoring of nickel sulfide clusters as active sites and cocatalysts for photocatalytic antibiotic degradation and bacterial inactivation.

Achieving photocatalytic antibiotic degradation and bacterial inactivation with high efficiency remains a challenging mission to originate a clean environment. In this work, ultra-small NiS clusters were in-situ grew on photoactive ZnInS nanoflower supports to form a NiS/ZnInS heterojunction, in which a strong and surface-limited binding was formed between the NiS clusters and ZnInS supports. The in-situ formed NiS clusters not only appeased interfacial charge transfer resistance of the heterojunction but also eventuated a strong built-in electric field, resulting a fast electron migration from ZnInS to NiS clusters functioned as cocatalyst and active sites to boost the separation efficiency of photogenerated carriers.

Embedding Cu3P quantum dots onto BiOCl nanosheets as a 0D/2D S-scheme heterojunction for photocatalytic antibiotic degradation.

The development of highly efficient photocatalysts is vital for solvinge the problem of environmental pollution. In this study, a novel zero-/two-dimensional (0D/2D) S-scheme heterojunction was fabricated by integrating 0D copper phosphide (CuP) quantum dots (QDs) with a size in the range of 3-8 nm onto 2D bismuth oxychloride (BiOCl) nanosheets using a self-assembly tactic. The CuP/BiOCl presented intimate interface contact and high photocatalytic activity for the degradation of antibiotics (tetracycline hydrochloride (TC), oxytetracycline, ofloxacin).

Elaborate the Mechanism of Ancient Classic Prescriptions (Erzhi Formula) in Reversing GIOP by Network Pharmacology Coupled with Zebrafish Verification.

Osteoporosis is a degenerative disease that endangers human health. At present, chemical drugs used for osteoporosis have serious side effects. Therefore, it is valuable to search herbs with high safety and good curative effect in antiosteoporosis.

Characteristics and outcome-related factors of seizure at the first onset of autoimmune encephalitis: A retrospective study.

Aims: Seizure outcome of autoimmune encephalitis (AE) varies from seizure-free to refractory epilepsy, and the associated factors remain unclear. We aimed to describe seizure characteristics, identify seizure outcome-related factors, and discuss the medication strategy of antiepileptic drugs (AEDs) at the first onset of AE.

Methods: We retrospectively studied the data of 86 patients with clinically diagnosed AE.

Protective Effect of Zuojin Fang on Lung Injury Induced by Sepsis through Downregulating the JAK1/STAT3 Signaling Pathway.

Lung injury was the common and serious complication of sepsis, a systemic inflammatory response syndrome caused by severe infections. Chinese medicine had unique advantages in attenuating inflammatory response, such as Zuojinfang (ZJF). ZJF was a classical compound herb formula composed of Coptidis Rhizoma and Euodiae Fructus in a ratio of 6 : 1.

A meta-analysis of case studies and clinical characteristics of hypertrophic olivary degeneration secondary to brainstem infarction.

Transsynaptic degeneration in the cerebellum and brainstem may give rise to a rare neurological condition with various clinical manifestations, namely hypertrophic olivary degeneration. The classical manifestations of hypertrophic olivary degeneration comprise myoclonus, palatal tremor, ataxia, and ocular symptoms. Any lesions interrupting the dentate-rubro-olivary pathway, referred to as the anatomic Guillain-Mollaret triangle, contribute to the broad aetiologies of hypertrophic olivary degeneration.

Protective Effects of Specneuzhenide on Renal Injury in Rats with Diabetic Nephropathy.

Background: We aim to investigate the protective effects and potential mechanisms in specneuzhenide (SPE) on renal injury in rats with diabetic nephropathy (DN).

Results: SPE could inhibit the decrease of body weight compared with the model group (P<0.05), and trigger improvement in the renal index (P<0.

Erzhi Formula Extracts Reverse Renal Injury in Diabetic Nephropathy Rats by Protecting the Renal Podocytes.

Podocytes injury was a crucial factor resulting in diabetic nephropathy (DN). Erzhi formula extract (EZF) was a clinical effective Chinese medicine on DN, but its mechanism was unclear. In this study, the main compounds of EZF and their pharmacokinetics in rat were detected by HPLC-MS/MS.

Umbelliferone alleviates hepatic injury in diabetic db/db mice via inhibiting inflammatory response and activating Nrf2-mediated antioxidant.

The current study was designed to investigate the protective effect and possible mechanisms of umbelliferone (Umb) on liver injury in diabetic C57BL/KsJ-db/db (dbdb) mice. Mice were divided into five groups: wild-type mice group (WY), dbdb mice group, dbdb mice + Metformin (100 mg/kg) group, dbdb mice + Umb (20, 40 mg/kg) group. Blood glucose regulation was assessed by an oral glucose tolerance test (OGTT).

Dihydrotestosterone modulates endothelial progenitor cell function via RhoA/ROCK pathway.

Background: Previous findings indicate that testosterone level is negatively correlated with the incidence and mortality of cardiovascular diseases in men. Endothelial progenitor cells (EPCs) play a critical role in endothelial healing and vascular integrity. This study aimed to examine the effects of dihydrotestosterone (DHT), an active metabolite of testosterone, on human EPC function and investigate the underlying mechanism.

Association between retinol-binding protein 4 and polycystic ovary syndrome: a meta-analysis.

Studies have examined the association between retinol-binding protein 4 (RBP4) and polycystic ovary syndrome (PCOS). However, the results have been inconsistent. To investigate the association between RBP4 and PCOS, we performed a meta-analysis.