Simultaneous Analysis of the Metabolome and Lipidome Using Polarity Partition Two-Dimensional Liquid Chromatography-Mass Spectrometry.

Comprehensive metabolic profiling is a considerable challenge for systems biology since the metabolites in biological samples have significant polarity differences. A heart-cutting two-dimensional liquid chromatography-mass spectrometry (2D-LC-MS) method-based polarity partition was established to analyze both the metabolome and lipidome in a single run. Based on the polarity partition strategy, metabolites with high polarity were retained and separated by one-dimensional hydrophilic chromatography, while low- and medium-polarity lipids were collected into a sample loop and injected into two-dimensional reversed-phase chromatography for separation.

Brominated flame retardants in black plastic kitchen utensils: Concentrations and human exposure implications.

Concerns exist that restricted brominated flame retardants (BFRs) present in waste polymers may have, as a result of recycling, inadvertently contaminated items not required to meet flame retardancy regulations (e.g. plastic kitchen utensils).

Vehicles as outdoor BFR sources: Evidence from an investigation of BFR occurrence in road dust.

The distribution of brominated flame retardants (BFRs) including ∑PBDEs, DBDPE, BTBPE, EH-TBB, BEH-TEBP and PBEB in road dust (RD) collected in Xinxiang, China was characterized. Analysis of RD samples indicated that the BFR abundance declined as traffic density decreased, with total mean levels of 292, 184, 163, 104 and 70 ng g dust at sites from traffic intersections, main roads, collector streets, bypasses and parks, respectively. A possible explanation for this phenomenon is that the majority of BFRs may be emitted from the interior of vehicles via their ventilation systems.

Ozonation of indomethacin: Kinetics, mechanisms and toxicity.

Ozonation of a commonly used non-steroidal anti-inflammatory drug indomethacin (IM) was studied. Kinetic constants of IM with ozone and hydroxyl radicals were measured at an order of magnitude of 10Ms and 10Ms, respectively. IM was degraded within 7min under the lowest ozone dose, but TOC removal was only 50% even under the highest ozone dose used in the experiments.

Concentrations of "legacy" and novel brominated flame retardants in matched samples of UK kitchen and living room/bedroom dust.

Concentrations of polybrominated diphenyl ethers (PBDEs), hexabromocyclododecanes (HBCDDs) and 5 novel brominated flame retardants (NBFRs) were measured in paired samples of kitchen and living room/bedroom dust sampled in 2015 from 30 UK homes. BDE-209 was most abundant (22-170,000 ng/g), followed by γ-HBCDD (1.7-21,000 ng/g), α-HBCDD (5.

Ozonation of trimethoprim in aqueous solution: identification of reaction products and their toxicity.

This work aimed to better understand the ozonation process of a typical antibiotic pharmaceutical, trimethoprim in aqueous solution. The parent compound was almost completely degraded with ozone dose up to 3.5 mg/L with no mineralization.