LncRNA MALAT1 Promotes Neuronal Apoptosis During Spinal Cord Injury Through miR-199a-5p/ PRDM5 Axis.

Aim: To determine the regulation of long non-coding RNA (lncRNA) MALAT1 on neuronal apoptosis during spinal cord injury (SCI) and to explore its possible mechanisms.

Material And Methods: The motor ability of SCI rat models and apoptosis in spinal cord tissue were evaluated. Primary spinal cord neurons (SCNs) were isolated and treated with H2O2 before cell transfection.

Blockage of miR-485-5p on Cortical Neuronal Apoptosis Induced by Oxygen and Glucose Deprivation/Reoxygenation Through Inactivating MAPK Pathway.

This study is designed to explore the role of miR-485-5p in hypoxia/reoxygenation-induced neuronal injury in primary rat cortical neurons. Hypoxia/reoxygenation model was established through oxygen and glucose deprivation/reoxygenation (OGD/R). RN-c cells were transfected with miR-485-5p mimics, miR-485-5p inhibitors, si-SOX6, pCNDA3.

Completely resorption of autologous skull flap after orthotopic transplantation: a case report.

Autologous skull flaps were frequently used in craniotomy, and after craniotomy, autologous skull flaps need to be replanted in situ at most of the time, and complications such as infection and resorption may occur. Ultimately, resorption may result in dislocation of the autologous skull flaps. Here we describe a case of completely resorption of autologous skull flap shortly after orthotopic transplantation which required an extra cranioplasty and potential causes were discussed.

Solitary skull metastasis as the first symptom of hepatocellular carcinoma: case report and literature review.

Skull metastasis from hepatocellular carcinoma (HCC) is reported rarely. In addition, solitary skull metastasis as the first symptom of HCC is reported even less. Here, we reported a case of solitary skull metastasis as the first symptom of HCC and reviewed the literature on skull metastasis.