New Polyene Macrolide Compounds from Mangrove-Derived Strain GXIMD 06359: Isolation, Antifungal Activity, and Mechanism against .

Mangrove-derived actinomycetes represent a rich source of novel bioactive natural products in drug discovery. In this study, four new polyene macrolide antibiotics antifungalmycin B-E (-), along with seven known analogs (-), were isolated from the fermentation broth of the mangrove strain GXIMD 06359. All compounds from this strain were purified using semi-preparative HPLC and Sephadex LH-20 gel filtration while following an antifungal activity-guided fractionation.

Ursolic acid induces human hepatoma cell line SMMC-7721 apoptosis via p53-dependent pathway.

Background: Ursolic acid (UA) is a ubiquitous molecule in the plant kingdom with specific anticancer effects that have been shown in vitro and in vivo. Although UA can inhibit the proliferation of liver cancer cells and induce apoptosis of many types of tumor cells, the molecular mechanism of its anti-hepatoma activity is still not well defined. The objective of this study was to investigate the inhibitory effect and mechanisms of UA on the human hepatoma cell line SMMC-7721.