A reduction pathway was developed to tune the fluorescence quantum yield (QY) and emission wavelength of carbon dots (CDs). Reducing the original CDs (QY ca. 1.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
August 2018
Amyloid-beta peptide 1-42 (Aβ) is known as a component of amyloid plaques in association with Alzheimer's disease. Herein, we developed a reliable and remarkably sensitive sandwich immunoassay to detect the Aβ using quantum dots (QDs) as fluorescent label. In the presence of Aβ, the biotinylated Anti-beta Amyloid 1-16 (N-Ab) recognized the target and formed C-Ab-Aβ-N-Ab sandwich immunocomplexes.
View Article and Find Full Text PDFThe extent of resection is a significant prognostic factor in glioma patients. However, the maximum safe resection level is difficult to determine due to the inherent infiltrative character of tumors. Recently, fluorescence-guided surgery has emerged as a new technique that allows safe resection of glioma.
View Article and Find Full Text PDFDelivery of imaging agents to brain glioma is challenging because the blood-brain barrier (BBB) functions as a physiological checkpoint guarding the central nervous system from circulating large molecules. Moreover, the ability of existing probes to target glioma has been insufficient and needs to be improved. In present study, PEG-based long circulation, CdSe/ZnS quantum dots (QDs)-based nanoscale and fluorescence, asparagines-glycine-arginine peptides (NGR)-based specific CD13 recognition were integrated to design and synthesize a novel nanoprobe by conjugating biotinylated NGR peptides to avidin-PEG-coated QDs.
View Article and Find Full Text PDFAlzheimer's disease (AD) is the primary cause of dementia over the age of 60, affecting more than 35 million people worldwide. Methods for early diagnosis of AD are critical for the development of effective treatments to combat this debilitating disease. It was confirmed that amyloid-beta peptide 1-42 (Aβ(1-42)) is the biomarker of its early diagnosis.
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