A sensitive UPLC-MS/MS method for simultaneous quantification of one-carbon metabolites & co-factors in human plasma.

One-carbon metabolism is an important metabolic pathway involved in many diseases, such as congenital malformations, tumours, cardiovascular diseases, anaemia, depression, cognitive diseases and liver disease. However, the current methods have specific defects in detecting and qualifying the related compounds of one-carbon metabolism. In this study, a validated method was established to simultaneously quantify 22 one-carbon metabolites & co-factors in human plasma and applied to the study of correlation between one-carbon metabolism and colorectal cancer in human plasma samples, which were from 44 healthy subjects and 55 colorectal cancer patients.

Femtosecond Laser Thermal Accumulation-Triggered Micro-/Nanostructures with Patternable and Controllable Wettability Towards Liquid Manipulating.

Versatile liquid manipulating surfaces combining patternable and controllable wettability have recently motivated considerable attention owing to their significant advantages in droplet-solid impacting behaviors, microdroplet self-removal, and liquid-liquid interface reaction applications. However, developing a facile and efficient method to fabricate these versatile surfaces remains an enormous challenge. In this paper, a strategy for the fabrication of liquid manipulating surfaces with patternable and controllable wettability on Polyimide (PI) film based on femtosecond laser thermal accumulation engineering is proposed.

Hardware implementation of photoelectrically modulated dendritic arithmetic and spike-timing-dependent plasticity enabled by an ion-coupling gate-tunable vertical 0D-perovskite/2D-MoS hybrid-dimensional van der Waals heterostructure.

Brain-inspired nanodevices have been demonstrated to possess outstanding characteristics for implementing neuromorphic computing. Among these devices, photoelectrically modulated neuromorphic transistors are regarded as the basic building blocks for applications in emerging brain-like devices. However, to date, efficient optoelectronic-hybrid neuromorphic devices are still lacking.

Efficacy and safety of Levetiracetam as adjunctive treatment in children with focal onset seizures: A systematic review and meta-analysis.

Objective: To assess the efficacy and safety of levetiracetam (LEV) as adjunctive treatment in children (0-18 years) with focal-onset seizures (FOS) with a larger dataset.

Methods: A pooled analysis would be performed for prospective clinical trials and a meta-analysis for controlled studies. Retrospectives studies were also summarized using descriptive statistics.

2D electric-double-layer phototransistor for photoelectronic and spatiotemporal hybrid neuromorphic integration.

The hardware implementation of neuromorphic computing has attracted growing interest as a promising candidate for confronting the bottleneck of traditional von Neumann computers. However, most previous reports are focusd on emulating the synaptic behaviors by a mono-mode using an electric-driving or photo-driving approach, resulting in a big challenge to synchronously handle the natural photoelectric information. Herein, we report a multifunctional photoelectronic hybrid-integrated synaptic device based on the electric-double-layer (EDL) MoS2 phototransistor.

Transient security transistors self-supported on biodegradable natural-polymer membranes for brain-inspired neuromorphic applications.

Transient electronics, a new generation of electronics that can physically or functionally vanish on demand, are very promising for future "green" security biocompatible electronics. At the same time, hardware implementation of biological synapses is highly desirable for emerging brain-like neuromorphic computational systems that could look beyond the conventional von Neumann architecture. Here, a hardware-security physically-transient bidirectional artificial synapse network based on a dual in-plane-gate Al-Zn-O neuromorphic transistor was fabricated on free-standing laterally-coupled biopolymer electrolyte membranes (sodium alginate).