Identifying Alzheimer's disease and mild cognitive impairment with atlas-based multi-modal metrics.

Introduction: Multi-modal neuroimaging metrics in combination with advanced machine learning techniques have attracted more and more attention for an effective multi-class identification of Alzheimer's disease (AD), mild cognitive impairment (MCI) and health controls (HC) recently.

Methods: In this paper, a total of 180 subjects consisting of 44 AD, 66 MCI and 58 HC subjects were enrolled, and the multi-modalities of the resting-state functional magnetic resonance imaging (rs-fMRI) and the structural MRI (sMRI) for all participants were obtained. Then, four kinds of metrics including the Hurst exponent (HE) metric and bilateral hippocampus seed independently based connectivity metrics generated from fMRI data, and the gray matter volume (GMV) metric obtained from sMRI data, were calculated and extracted in each region of interest (ROI) based on a newly proposed automated anatomical Labeling (AAL3) atlas after data pre-processing.

[Clinical application of plasma exchange combined with continuous veno-venous hemofiltration dialysis in children with refractory Kawasaki disease shock syndrome].

Objectives: To study the role of plasma exchange combined with continuous blood purification in the treatment of refractory Kawasaki disease shock syndrome (KDSS).

Methods: A total of 35 children with KDSS who were hospitalized in the Department of Pediatric Intensive Care Unit, Hunan Children's Hospital, from January 2019 to August 2022 were included as subjects. According to whether plasma exchange combined with continuous veno-venous hemofiltration dialysis was performed, they were divided into a purification group with 12 patients and a conventional group with 23 patients.

A Multi-Modal and Multi-Atlas Integrated Framework for Identification of Mild Cognitive Impairment.

Background: Multi-modal neuroimaging with appropriate atlas is vital for effectively differentiating mild cognitive impairment (MCI) from healthy controls (HC).

Methods: The resting-state functional magnetic resonance imaging (rs-fMRI) and structural MRI (sMRI) of 69 MCI patients and 61 HC subjects were collected. Then, the gray matter volumes obtained from the sMRI and Hurst exponent (HE) values calculated from rs-fMRI data in the Automated Anatomical Labeling (AAL-90), Brainnetome (BN-246), Harvard-Oxford (HOA-112) and AAL3-170 atlases were extracted, respectively.

Integrin α4β1/VCAM-1 Interaction Evokes Dynamic Cell Aggregation Between Immune Cells and Human Lung Microvascular Endothelial Cells at Infectious Hemolysis.

Bacterial and viral infection is a common cause of pneumonia, respiratory failure, and even acute respiratory distress syndrome. Increasing evidence indicates that red blood cells (RBCs) may contribute to immune response and inflammation. However, the precise molecular mechanisms that link RBC and hemolysis to the development and progression of inflammatory pathologies are not entirely understood.

Penicilliosis marneffei in HIV negative children: three case reports.

This study aimed to report the clinical characteristics of penicilliosis marneffei (PSM) in three children negative to HIV. Three children were diagnosed with PSM in the Department of Emergency Medicine, Hunan Children's Hospital between February 2016 to July 2020. The clinical characteristics, laboratory findings, and concomitant diseases were recorded, and the related literatures were reviewed.

[Impact of continuous blood purification on T cell subsets in children with severe sepsis].

Objective: To investigate the impact of continuous blood purification (CBP) on T-cell subsets and prognosis in children with severe sepsis.

Methods: A total of 42 children with severe sepsis were randomly divided into a control group (n=22) and a CBP group (n=20). The patients in the control group received conventional treatment, while those in the CBP group underwent continuous veno-venous hemofiltration daily 12-24 hours for 3 days besides conventional treatment.

[Clinical risk factors for capillary leak syndrome in children with sepsis].

Objective: To investigate the clinical features of capillary leak syndrome (CLS) in children with sepsis, and to analyze its risk factors.

Methods: Clinical data of 384 children with sepsis was studied retrospectively. They included 304 cases of general sepsis, 54 cases of severe sepsis and 26 cases of septic shock, and were divided into non-CLS (n=356) and CLS groups (n=28).

[Relationship between blood lactate level and disease severity in critically ill children].

Objective: To study the relationship between blood lactate level and disease severity in critically ill children.

Methods: The clinical data of 232 children who were critically ill between September and December, 2010 were retrospectively studied. According to blood lactate levels within 24 hrs of admission, the 232 patients were classified into three groups: normal (n=146), high lacticemia (n=72) and lactic acidosis (n=14).

[Correlation of hypoproteinemia with C-reactive protein and procalcitonin in children with sepsis].

Objective: To investigate the correlation of hypoproteinemia with inflammation parameters C-reactive protein (CRP), procalcitonin (PCT) and WBC in children with sepsis.

Methods: Seventy-three children with sepsis (including 22 severe sepsis) and 40 non-sepsis children (control group) were enrolled. Serum albumin levels were measured on admission.