Regulatory roles of KDR antisense oligonucleotide on the proliferation of human prostate cancer cell line PC-3.

Purpose: To explore the regulatory roles of antisense oligonucleotide (ASODN) of vascular endothelial growth factor receptor 2/ VEGFR2 (kinase insert domain-containing receptor, KDR) on the proliferation of PC-3 human prostate cancer cell line.

Methods: Different concentrations of synthetic sense and antisense KDR oligonucleotides were transfected into PC-3 human prostate cancer cell line. The inhibitory effects of oligonucleotides on tumor cell proliferation, KDR mRNA expression, cell cycle distribution and cell apoptosis were analyzed.

[Relationship between resting heart rate and carotid artery structure in young hypertensive patients].

Objective: To investigate the relationship between resting heart rate (RHR) and carotid artery structure in young hypertensive patients.

Methods: A total of 663 primary hypertensive patients aged between 18 and 45 (38.01 ± 5.