Publications by authors named "Jianghong Cao"
Nomogram for the prediction of tigecycline-induced hypofibrinogenaemia in a Chinese population.
Int J Antimicrob Agents
February 2024
Article Synopsis
- Tigecycline is used for multi-drug-resistant infections in China, but its combination with drugs like valproic acid or voriconazole may increase the risk of hypofibrinogenaemia, a condition marked by low fibrinogen levels.
- A study developed a predictive nomogram using data from 611 patients to identify factors leading to tigecycline-induced hypofibrinogenaemia, which included total dose, age, and blood clotting metrics.
- The results indicated that using tigecycline with voriconazole heightens the risk of hypofibrinogenaemia, particularly in patients with malignant hematologic diseases, with recommended treatment durations of 10 days for the general population and
Cardiac insufficiency has been considered to be a common cause of extubation failure. Some studies have shown that central venous pressure (CVP) and brain natriuretic peptide (BNP) are able to predict extubation outcomes. Therefore, we conducted a pooled analysis to evaluate the potential of CVP and BNP levels as predictors of extubation outcomes, using a cohort of critically ill patients who were on mechanical ventilation (MV).
View Article and Find Full Text PDFBackground: We intended to investigate the function of circular RNA RasGEF domain family member 1B (circ_RASGEF1B) in lipopolysaccharide (LPS)-induced septic acute kidney injury (AKI) cell model and its associated mechanism.
Methods: TCMK-1 cells were exposed to 10 μg/mL LPS for 24 h to establish a septic AKI cell model. Mice were intraperitoneally injected with 10 mg/kg LPS to establish a septic AKI mice model.
Background: Acute lung injury (ALI) is an early complication of sepsis and it is also considered as an important cause of high mortality in sepsis patients. This research aimed to explore the potential role and mechanism of long non-coding RNA (lncRNA) cancer susceptibility candidate 2 (CASC2) in sepsis-induced ALI.
Methods: The levels of CASC2, microRNA-152-3p (miR-152-3p) and pyruvate dehydrogenase kinase 4 (PDK4) in sepsis patients and LPS-treated HPAEpiC were detected by quantitative real-time PCR and western blot.