Study on Antidepressant Effect and Mechanism of Crocin Mediated by the mTOR Signaling Pathway.

Crocin is a monomer of Chinese traditional herbs extracted from saffron, relieving depression-like behavior. However, its underlying mechanism of action remains unclear. Herein, we explored whether crocin's antidepressant effect depended on the mammalian target of the rapamycin (mTOR) signaling pathway.

The C-terminal domains of Arabidopsis GL3/EGL3/TT8 interact with JAZ proteins and mediate dimeric interactions.

The phytohormone jasmonates (JAs) regulate plant development, growth, secondary metabolism, and defense responses. JAs act through CORONATINE INSENSITIVE1 (COI1) to induce the degradation of JA ZIM-domain (JAZ) proteins, and activate JAZ-repressed transcription factors to regulate plant response. We previously showed that the basic helix-loop-helix (bHLH) and MYB members of the WD-repeat/bHLH/MYB complex interacted with JAZs and mediated JA-induced anthocyanin accumulation and trichome initiation.