Dysregulation of Iron Homeostasis Mediated by FTH Increases Ferroptosis Sensitivity in TP53-Mutant Glioblastoma.

Iron metabolism is a critical factor in tumorigenesis and development. Although TP53 mutations are prevalent in glioblastoma (GBM), the mechanisms by which TP53 regulates iron metabolism remain elusive. We reveal an imbalance iron homeostasis in GBM via TCGA database analysis.

Programmable Persistent Room Temperature Phosphorescence Switches through Wavelength-Selective Photoactivation.

Controlling multicolor persistent room-temperature phosphorescence (RTP) through photoirradiation holds fundamental significance but remains a significant challenge. In this study, we engineered a wavelength-selective photoresponsive system utilizing the Förster resonance energy transfer strategy. This system integrates a photoactivated long-lived luminescent material as the energy donor with a fluorescent photoswitch as the energy acceptor, facilitating programmable persistent luminescence switches.

Mo-Doped NaFe(PO)PO/C Composites for High-Rate and Long-Life Sodium-Ion Batteries.

NaFe(PO)PO/C (NFPP) is a promising cathode material for sodium-ion batteries, but its electrochemical performance is heavily impeded by its low electronic conductivity. To address this, pure-phase Mo-doped NaFeMo(PO)PO/C (Mox-NFPP, x = 0, 0.05, 0.

Selective Memory Recursive Least Squares: Recast Forgetting Into Memory in RBF Neural Network-Based Real-Time Learning.

In radial basis function neural network (RBFNN)-based real-time learning tasks, forgetting mechanisms are widely used such that the neural network can keep its sensitivity to new data. However, with forgetting mechanisms, some useful knowledge will get lost simply because they are learned a long time ago, which we refer to as the passive knowledge forgetting phenomenon. To address this problem, this article proposes a real-time training method named selective memory recursive least squares (SMRLS) in which the classical forgetting mechanisms are recast into a memory mechanism.

Influence of Fertilization Methods and Types on Wheat Rhizosphere Microbiome Community and Functions.

To investigate the effects of fertilization methods and types on wheat rhizosphere microorganisms, macroelement (N, K) and microelement (Zn) fertilizers were applied on wheat by foliar spraying (FS) and root irrigation (RI) methods in a field experiment. The results indicated that fertilization methods and types can have significant impacts on the diversity and structure of rhizospheric microorganisms in wheat. The application method produced more significant effects than the fertilizer type.

Simultaneously enhancing organic phosphorescence quantum yields and lifetimes for triphenylphosphine salt doped polymer films.

Simultaneously enhancing the quantum yields and luminescence lifetimes of organic persistent room temperature phosphorescence (RTP) molecules is a priority in the organic photonic area, but it remains a formidable challenge. Here, an effective strategy was proposed to improve both quantum efficiencies and emission decay times for phosphorescent triphenylphosphine salts. This approach involves integrating an electron donor unit into a triphenylphosphine salt an alkyl chain.

Research on dynamic characteristics and structural optimization of porous gas bearings in linear compressors.

In order to study the influence of structural parameters of porous gas bearing and operating parameters of linear compressor on the static and dynamic performance of porous gas bearing, based on gas lubrication theory, Darcy's law and Reynolds equation, the mathematical model and simulation model of porous gas bearing of linear compressor are derived and established. The static and dynamic characteristics of the porous gas bearing of the linear compressor are studied by using Fluent software simulation. According to the simulation results, the effects of inlet pressure, porous material thickness and gas gap on the gas consumption and bearing capacity of the porous gas bearing under different eccentricities are analyzed.

Thermal-Conductivity-Enhancing Copper-Plated Expanded Graphite/Paraffin Composite for Highly Stable Phase-Change Materials.

Paraffin (PA)/expanded graphite (EG) is an important composite phase change material with low cost, high heat storage, good thermal conductivity and cycling stability. Its thermal conductivity needs to be further improved for application in the thermal management system of power lithium-ion batteries. In this paper, copper plated expanded graphite (CPEG) with 3D porous structure was prepared by electroless copper plating method, which was used as thermal conductivity enhancing material to replace part of EG in PA/EG composite materials.

Dynamic Metal-ligand Coordination for Fluorescence Color Regulation of Hydrazone-based Bistable Photoswitches.

Achieving effective manipulation of emission color in photoresponsive materials is crucial for various advanced photonic applications. In this study, we designed and synthesized a hydrazone compound 1, ethyl (Z)-2-(2-([2,2':6',2''-terpyridin]-4'-yl)hydrazineylidene)-2-(4-(diphenylamino)phenyl)acetate, which possesses a push-pull structure incorporating triphenylamine and terpyridine. The emission intensity of compound 1 can be repeatedly switched "off" and "on" by irradiation with visible light and UV light, which induces the isomerization transition between the Z and E forms.

Efficacy of neurointerventional therapy in patients with ischemic stroke and risk factors affecting cognitive function recovery.

Objective: To investigate the efficacy of neurointervention combined with intravenous thrombolysis in ischemic stroke patients and the risk factors affecting cognitive function recovery.

Methods: A total of 114 patients with acute ischemic stroke (AIS) treated in Baoji People's Hospital from January 2017 to December 2020 were retrospectively selected and divided into an observation group and a control group according to different treatment methods. The observation group was treated with neurointervention + intravenous thrombolysis (n = 64), and the control group underwent intravenous thrombolysis (n = 50).

Diseased-induced multifaceted variations in community assembly and functions of plant-associated microbiomes.

Plant-associated microorganisms are believed to be part of the so-called extended plant phenotypes, affecting plant growth and health. Understanding how plant-associated microorganisms respond to pathogen invasion is crucial to controlling plant diseases through microbiome manipulation. In this study, healthy and diseased (bacterial wilt disease, BWD) tomato ( L.

Hsa_circRNA_001859 regulates pancreatic cancer progression and epithelial-mesenchymal transition through the miR-21-5p/SLC38A2 pathway.

Objective: This study attempts to investigate whether hsa_circRNA_001859 (circ_001859) could regulate the proliferation and invasion of pancreatic cancer through the miR-21-5p/SLC38A2 pathway.

Methods: GSE79634 microarray was analyzed with R package. The expression of circ_001859 in pancreatic cancer tissues and cells was verified by qRT-PCR.

Double-Center-Based Iris Localization and Segmentation in Cooperative Environment with Visible Illumination.

Iris recognition has been considered as one of the most accurate and reliable biometric technologies, and it is widely used in security applications. Iris segmentation and iris localization, as important preprocessing tasks for iris biometrics, jointly determine the valid iris part of the input eye image; however, iris images that have been captured in user non-cooperative and visible illumination environments often suffer from adverse noise (e.g.

Conformation-dependent dynamic organic phosphorescence through thermal energy driven molecular rotations.

Organic room-temperature phosphorescent (RTP) materials exhibiting reversible changes in optical properties upon exposure to external stimuli have shown great potential in diverse optoelectronic fields. Particularly, dynamic manipulation of response behaviors for such materials is of fundamental significance, but it remains a formidable challenge. Herein, a series of RTP polymers were prepared by incorporating phosphorescent rotors into polymer backbone, and these materials show color-tunable persistent luminescence upon excitation at different wavelengths.

Root Exudates of Ginger Induced by Infection Could Inhibit Bacterial Wilt.

Bacterial wilt caused by (Rs) is one of the most important diseases found in ginger; however, the disease resistance mechanisms dependent on root bacteria and exudates are unclear. In the present study, we analyzed the changes in the composition of rhizobacteria, endobacteria, and root exudates during the pathogenesis of bacterial wilt using high-throughput sequencing and gas chromatography-mass spectrometry (GC-MS). Rs caused bacterial wilt in ginger with an incidence of 50.

Deterministic learning-based neural network control with adaptive phase compensation.

Under the persistent excitation (PE) condition, the real dynamics of the nonlinear system can be obtained through the deterministic learning-based radial basis function neural network (RBFNN) control. However, in this scheme, the learning speed and accuracy are limited by the tradeoff between the PE levels and the approximation capabilities of the neural network (NN). Inspired by the frequency domain phase compensation of linear time-invariant (LTI) systems, this paper presents an adaptive phase compensator employing the pure time delay to improve the performance of the deterministic learning-based adaptive feedforward control with the reference input known a priori.

Significant differences in the electrochemical activity of black phosphorus anodes prepared under different atmospheres.

The effects of atmosphere and temperature on the electrochemical reversibility of black phosphorus (BP) anodes were investigated. BP anodes prepared in ambient air exhibited much-enhanced electrochemical activity due to the newly formed CuP phase. This work highlights the importance of maintaining intragranular electronic conduction for developing advanced BP-based anodes with high reversible capacities.

Realization of thousand-second improved confinement plasma with Super I-mode in Tokamak EAST.

Mastering nuclear fusion, which is an abundant, safe, and environmentally competitive energy, is a great challenge for humanity. Tokamak represents one of the most promising paths toward controlled fusion. Obtaining a high-performance, steady-state, and long-pulse plasma regime remains a critical issue.

Rapid discrimination of the authenticity and geographical origin of bear bile powder using stable isotope ratio and elemental analysis.

Bear bile powder (BBP) is one of the most famous traditional Chinese medicines derived from animals. It has a long history of medicinal use and is widely used in the treatment of hepatobiliary and ophthalmic diseases. Due to its similar morphological characterizations and chemical composition compared with other bile powders, it is difficult to accurately identify its authenticity.

Identification and Quality Evaluation of Velvet Antler by DNA Barcoding and Stable Isotope Techniques Combined with Chemometrics.

This study aimed to identify Velvet antler and its counterfeits and to further evaluate their quality. Mitochondrial cytochrome (Cytb) was used as a target gene to identify Velvet antler samples, and a DNA barcoding method was established for species origin identification in Velvet antlers. After identification, the stable isotope contents and ratios were adopted to evaluate the quality of different specifications of authentic Velvet antler in combination with chemometrics.