Comparative efficacy of multiple non-invasive brain stimulation to treat major depressive disorder in older patients: A systematic review and network meta-analysis study based on randomized controlled trials.

Background: Major depressive disorder (MDD) is prevalent among older patients and is frequently associated with cognitive decline and a reduced quality of life. Non-invasive brain stimulation (NIBS) techniques show promise for treating MDD, but their comparative efficacy and safety older populations remain unclear. This study aimed to compare the efficacy and cognitive effects of various NIBS techniques in treating MDD in older patients.

Insufficient Effective Time of Suberanilohydroxamic Acid, a Deacetylase Inhibitor, Treatment Promotes PC3 Cell Growth.

Castration-resistant prostate cancer (CRPC) contributes mostly to prostate cancer-specific mortality, and conventional castration therapy is almost ineffective, new therapies are needed. As a new potential anti-cancer drug, histone deacetylases (HDACs) inhibitors were demonstrated to be effective in inhibiting drug-resistance cancers in preclinical studies, but the results from clinical trials on CRPC patients were disappointing, and the reasons are unknown. In this study, we investigated the effect of suberanilohydroxamic acid (SAHA), a broad-spectrum pan-HDAC inhibitor, on proliferation, apoptosis, cell cycle progression in PC3 cells, and found that, unlike significant inhibiting effects at high-dose, low-dose SAHA significantly promoted PC3 cell growth.

Rapid, in-situ evaluation of sunflower seed freshness and vigor using Raman microspectroscopy scanning of carotenoids.

An ultra-rapid, in-situ Raman microscopy strategy was developed for judging both seed freshness and seed vigor based on relative quantification of carotenoids content during sunflower seed germination. The carotenoids content was determined using the ratio of the Raman peak intensities at 1525 and 1268 cm (I). When different samples (harvest times and storage conditions) were soaked in water for 0-24 h, the carotenoids content in the embryonic axes gradually increased, with the carotenoids higher in fresher seeds.

Microwave hyperthermia enhances radiosensitization by decreasing DNA repair efficiency and inducing oxidative stress in PC3 prostatic adenocarcinoma cells.

Purpose: Radiotherapy (RT) is the primary treatment for prostate cancer (PCa); however, the emergence of castration-resistant prostate cancer (CRPC) often leads to treatment failure and cancer-related deaths. In this study, we aimed to explore the use of microwave hyperthermia (MW-HT) to sensitize PCa to RT and investigate the underlying molecular mechanisms.

Methods: We developed a dedicated MW-HT heating setup, created an and MW-HT + RT treatment model for CRPC.

Fabricating the multibranch carboxyl-modified cellulose for hemorrhage control.

Excessive bleeding is associated with a high mortality risk. In this study, citric acid and ascorbic acid were sequentially modified on the surface of microcrystalline cellulose (MCAA) to increase its carboxyl content, and their potential as hemostatic materials was investigated. The MCAA exhibited a carboxylic group content of 9.

Dosage effect of micron zero-valent iron during thermophilic anaerobic digestion of waste activated sludge: Performance and functional community.

This work examined the performance and microbial traits in a thermophilic anaerobic digestion (TAD) of waste activated sludge that was impacted by micron zero valent iron (mZVI). Results showed that methane production was promoted by 0.8, 11.

Tc-pertechnetate thyroid static scintigraphy unexpectedly revealed ectopic gastric mucosa of upper esophagus.

Technetium-99m (Tc)-pertechnetate can be taken up by both gastric mucosa and thyroid tissue. Ectopic gastric mucosa of upper esophagus found in thyroid scintigraphy is rare. We reported a 31-year-old woman who underwent Tc-pertechnetate thyroid static scintigraphy for abnormal ultrasound findings.

H NMR-based metabolomics combined with chemometrics to detect edible oil adulteration in huajiao (Zanthoxylum bungeanum Maxim.).

Huajiao is a highly valued spice that is susceptible to fraudulent adulteration, particularly the addition of edible oils to increase weight and improve color. Nuclear magnetic resonance (H NMR) and chemometrics were used to analyze 120 huajiao samples adulterated with different types and levels of edible oils. Using untargeted data and partial least squares-discriminant analysis (PLS-DA), the discrimination rate between types of adulteration reached 100% accuracy, and the R value of the prediction set for the level of adulteration using the targeted analysis dataset combined with PLS-regression methods reached 0.

African Swine Fever Virus MGF505-7R Interacts with Interferon Regulatory Factor 9 to Evade the Type I Interferon Signaling Pathway and Promote Viral Replication.

African swine fever (ASF) is an acute and severe infectious disease caused by the ASF virus (ASFV). The mortality rate of ASF in pigs can reach 100%, causing huge economic losses to the pig industry. Here, we found that ASFV protein MGF505-7R inhibited the beta interferon (IFN-β)-mediated Janus-activated kinase-signal transducer and activation of transcription (JAK-STAT) signaling.

Accelerated Evolution of H7N9 Subtype Influenza Virus under Vaccination Pressure.

No avian H7N9 outbreaks have occurred since the introduction of H7N9 inactivated vaccine in the fall of 2017. However, H7N9 is still prevalent in poultry. To surveil the prevalence, genetic characteristics, and antigenic changes of H7N9, over 7000 oropharyngeal and cloaca swab specimens were collected from live poultry markets and farms in 15 provinces of China from 2017 to 2019.

Genetic Evolution Characteristics of Genotype G57 Virus, A Dominant Genotype of H9N2 Avian Influenza Virus.

This study aimed to investigate the genetic evolution of the H9N2 avian influenza virus (AIV). Whole genome phylogenetic trees were constructed based on 306 H9N2 avian influenza strains collected in China from 2014 to 2019. The results showed that eight gene sequences were clustered separately according to their dominant clades, and a total of 10 genotypes were identified (seven of which were novel types).

Isolation and Characterization of Human Synovial Fluid-Derived Mesenchymal Stromal Cells from Popliteal Cyst.

Mesenchymal stem cells (MSCs) are multipotent progenitor cells in adult tissues. The aim of this study is to isolate and identify synovial fluid-derived mesenchymal stromal cells (SF-MSCs) from the popliteal cyst fluid of pediatric patients. SF-MSCs were collected from the popliteal cyst fluid of pediatric patients during cystectomy surgery.

New molecular evolutionary characteristics of H9N2 avian influenza virus in Guangdong Province, China.

To understand the evolution of H9N2 avian influenza virus genotype and its molecular evolution rate, we systematically analyzed 72 H9N2 avian influenza virus sequences isolated from Guangdong province from 2014 to 2018. We found three genotypes (G57, G68, and G118) of the H9N2 avian influenza virus, of which G118 is a newly discovered genotype and G57 is the dominant genotype. The internal gene cassette of the G57 genotype H9N2 avian influenza virus is a stable combination that can easily transport internal genes to other novel avian influenza viruses, and the internal gene cassettes of the G68 and G118 are identical to those of G57.

Sorption isotherms of brominated diphenyl ethers on natural soils with different organic carbon fractions.

Sorption isotherms of BDE-28 and BDE-47 on natural soils with different contents of soil organic matter (SOM) were investigated. Due to low water solubility of BDEs and resulted narrow ranges of aqueous equilibrium concentration, the linear distribution model showed similar and good fitting efficiency to the linear portion of nonlinear Freundlich curve. For the same sample, the linear and nonlinear model fitting sorption coefficients were close.

[Sorption behaviors of BDE-28 on natural soils].

The sorption kinetics and isotherms of BDE-28 on three natural soils with different soil organic matter fractions (f(oc)) were investigated. The results indicated that a two (fast and slow)-compartment first-order model was more appropriate for describing the sorption kinetic data, compared to a one-compartment first-order model, especially in the initial sorption stage within 25 h. The fast sorption was predominant during the whole sorption process from beginning to the apparent sorption equilibrium; while the contribution of the slow sorption to the total sorption amount gradually increased and then achieved a plateau at 49 h or 55 h.

[Distribution characteristics of trace pollutants in benthic mussels from the coastal areas of Bohai Sea and North Yellow Sea].

Based on the recent monitoring results, the concentration and distribution of persistent toxic substances in the benthic mussels from the coastal areas of Bohai Sea and North Yellow Sea were determined. The results indicated that, at over 36% of the total sampling sites, the tissue concentrations of petroleum hydrocarbons were higher than the Category I value (15 microg/g, wet weight) of the national marine biological quality standards, especially at the sites near Dalian Bay and Xincun in Hebei Province, the tissue concentrations even exceeded the Category III level (80 microg/g, wet weight). Moreover, higher tissue concentration of PHCs (over the Category I level) during recent years remained in the most monitoring sea areas.

Sorption kinetic characteristics of polybrominated diphenyl ethers on natural soils.

Sorption kinetic characteristics of BDE-28 and BDE-47 on five natural soils with different organic carbon fractions were investigated, and could be satisfactorily described by a two (fast and slow)-compartment first-order model with the ratio of rate constants ranged from 9 to 94 times. The fast compartment made a dominant contribution (71%-94%) to the total sorption amount in the whole process, and accounted for over 90% of the increase in the total sorption amount at initial 5 h. The influence of the slow compartment on the increase in the total sorption amount became principal (above 90%) in the subsequent stage approximately from 9 h or 25 h to the apparent equilibrium at 265 h.

[Geographical distribution of DDTs, PCBs and phthalate esters in coastal surface sediments of Yellow Sea].

Using the data of the second survey of marine pollution baseline, the geographical distribution and constitution were investigated, and preliminarily evaluated the ecological risk based on the corresponding sediment quality guidelines. The results showed that, the sites with high concentrations of PAEs over the corresponding guidelines were mainly located in the Dalian Bay (1 389.8 ng/g) and surrounding sea areas of Lvshun (1 928.

[Distribution of typical organic pollutants in benthic mussels from the inshore areas of Yellow Sea].

Based on the second national baseline survey on marine pollution, the concentration, distribution and potential ecological risk of typical organic pollutants in the benthic mussels from the inshore areas of Yellow Sea were determined. The results indicated that, at over 35% of the total sampling sites, the tissue concentrations of petroleum hydrocarbons were higher than the Category I (15 000 ng/g) of the national marine biological quality standards, and at the sites near Dalian Bay, the tissue concentrations even exceeded the Category II (50 000 ng/g). At minor sites located in Dalian Bay, Weihai and Jiaozhou Bay, relatively high concentrations of polycyclic aromatic hydrocarbons (PAHs) and phthalate esters (PAEs) occurred, while the concentrations of PAHs and PAEs in mussels at most other sites were low.

[Preparation and clinical application of an intelligent determination and analysis system for glomerular filtration rate].

Objective: To prepare an intelligent determination and analysis system for renal glomerular filtration rate(GFRBMAS), and to explore its value in clinical setting.

Methods: GFRBMAS was prepared by programming with VB 6.0 software.

Multi-residues of organic pollutants in surface sediments from littoral areas of the Yellow Sea, China.

Concentrations of all studied organic pollutants, except for DDTs, were greatest at sites in Dalian Bay, where surface sediment concentrations of PHCs, PAHs, PCBs and DDTs exceeded the corresponding ERL values. The sum concentration of DDTs was greatest in Haizhou Bay exceeding the related ERM value. In terms of compositions of PAHs and PAEs, the predominant components were the MMW and HMW compounds, DBP and DEHP, respectively.

Residual concentrations of micropollutants in benthic mussels in the coastal areas of Bohai Sea, North China.

Studies of heavy metals and organic pollutants in different benthic mussel species from Bohai Sea show that concentrations of Cd in mussels commonly exceed national biological quality standards. In addition, a site located in Laizhou Bay exhibits higher average concentrations of As, Hg and Pb with respect to the other sites. Residual levels of petroleum hydrocarbons at several sites in Liaodong Bay also exceed quality guidelines.

[Study of the clinical factors associated with glomerular filtration rate].

Objective: To investigate the relationship between glomerular filtration rate(GFR) and possible involved clinical factors and to offer an basis for building measurement GFR by the calculation method.

Methods: GFR from 46 cases of normal renal function group and 52 cases of renal insufficient group were determined by using clearance of 99mTc-DTPA, serum creatinine(SCr), urea nitrogen, uric, potassium, sodium, calcium and hemoglobin were determined. Simultaneously, heart rate, urine specific gravity, 24 hours urine protein quantum, average artery pressure, weight index and body surface area were determined.