Inhibition of xCT suppresses the efficacy of anti-PD-1/L1 melanoma treatment through exosomal PD-L1-induced macrophage M2 polarization.

Tumor cells increase glutamate release through the cystine/glutamate transporter cystine-glutamate exchange (xCT) to balance oxidative homeostasis in tumor cells and promote tumor progression. Although clinical studies have shown the potential of targeting programmed cell death 1 (PD-1)/programmed death ligand 1 (PD-L1) signaling in melanoma, response rates are low. However, it remains unclear how glutamate metabolism affects anti-PD-1/PD-L1 treatment efficacy in melanoma.

CD147 regulates melanoma metastasis via the NFAT1-MMP-9 pathway.

Although accumulating evidence had revealed that NFAT1 has oncogenic characteristics, the role of this molecule in melanoma cells remains unclear. Previous studies proved that CD147 plays a crucial function in melanoma cell metastasis and invasion through matrix metalloproteinase 9 (MMP-9) expression; however, the details of how CD147 regulates MMP-9 expression remain elusive. In this study, we demonstrated that CD147 and NFAT1 are overexpressed in the tissues of patients with primary and metastatic melanoma, which has shown a positive correlation.

A novel chalcone derivative has antitumor activity in melanoma by inducing DNA damage through the upregulation of ROS products.

Background: Melanoma is one of the most aggressive tumors with the remarkable characteristic of resistance to traditional chemotherapy and radiotherapy. Although targeted therapy and immunotherapy benefit advanced melanoma patient treatment, BRAFi (BRAF inhibitor) resistance and the lower response rates or severe side effects of immunotherapy have been observed, therefore, it is necessary to develop novel inhibitors for melanoma treatment.

Methods: We detected the cell proliferation of lj-1-59 in different melanoma cells by CCK 8 and colony formation assay.

Full dose, half dose, or discontinuation of etanercept biosimilar in early axial spondyloarthritis patients: a real-world study in China.

Introduction: To investigate the effect of dose maintenance, reduction, or discontinuation of the etanercept biosimilar Yisaipu (YSP) on early axial spondyloarthritis (axSpA) patients in remission with YSP 50 mg once weekly (QW).

Material And Methods: Patients were enrolled in three groups: full dose (YSP50), half dose (YSP25), and discontinuation (YSP0). Patients were assessed by the same rheumatologist every 8 weeks for 48 weeks.

TRAF6 regulates EGF-induced cell transformation and cSCC malignant phenotype through CD147/EGFR.

TRAF6, a well-known adapter molecule, plays pivotal role in TLR/IL-1R associated signaling pathway. Although TRAF6 has been shown to have oncogenic activity in various malignant tumors, the details remain unclear. In this study, we demonstrated that TRAF6 facilitates Ras (G12V) and EGF-induced cellular transformation through EGFR.

Mechanisms underlying the wound healing potential of propolis based on its in vitro antioxidant activity.

Background: Propolis is a resinous substance collected by honeybees, Apis mellifera, from various plant sources. Having various pharmacological and biological activities, it has been used in folk medicine and complementary therapies since ancient times.

Purpose: To evaluate the effects and underlying mechanism of the protective effects of the ethanol extract of Chinese propolis (EECP) on L929 cells injured by hydrogen peroxide (HO).

Does the choice of tariff matter?: A comparison of EQ-5D-5L utility scores using Chinese, UK, and Japanese tariffs on patients with psoriasis vulgaris in Central South China.

There is an increasing trend globally to develop country-specific tariffs that can theoretically better reflect population's preferences on health states for preference-based health-related quality-of-life instruments, also known as multiattribute utility instruments. This study focused on the most recently developed 5-level version of EuroQol-5 Dimension (EQ-5D) questionnaire, 1 of the world's most well-known multiattribute utility instruments, and aimed to empirically explore the agreements and known-group validities of applying the country-specific tariff versus tariffs developed from other countries using a sample of psoriasis vulgaris patients in Mainland China.A convenience sampling framework was adopted to recruit patients diagnosed with psoriasis vulgaris from Xiangya Hospital, Central South University, China, between May 2014 and February 2015.

[Clinical characteristics of urticaria in children versus adults].

Objective: To study the clinical characteristics of urticaria in children versus adults, and to provide reference for the etiological analysis, disease evaluation, and treatment of urticaria in children.

Methods: The clinical data of 2 411 patients with urticaria who visited the Department of Dermatology at Xiangya Hospital of Central South University from January 2013 to May 2017 were collected to study their socio-demographic characteristics. The clinical characteristics of urticaria were compared between the 68 children and 672 adults of the 740 patients with complete follow-up data.

Evidence of Apis cerana Sacbrood virus Infection in Apis mellifera.

Sacbrood virus(SBV) is one of the most destructive viruses in the Asian honeybee Apis cerana but is much less destructive in Apis mellifera In previous studies, SBV isolates infecting A. cerana(AcSBV) and SBV isolates infecting A. mellifera(AmSBV) were identified as different serotypes, suggesting a species barrier in SBV infection.

[A clinical analysis of 509 cases of sacroiliitis].

Objective: To study the clinical features of sacroiliitis and differential diagnosis.

Methods: Totally 509 patients with chief complaints of back pain and diagnosed as sacroiliitis from January 2007 to January in Chinese PLA General Hospital were enrolled. The clinical manifestations, laboratory examinations, imaging and pathological data of the 509 patients were retrospectively analyzed.

[The clinical characteristics of 26 cases of amyopathic dermatomyositis].

Objective: To analyze the clinical characteristics of amyopathic dermatomyositis (ADM).

Methods: Twenty six patients diagnosed as ADM from January 2006 to January 2010 in PLA General Hospital were retrospectively analyzed. The clinical manifestation, laboratory findings, imaging manifestations, treatment and prognosis of the 26 patients were recorded.

[Advance in studies on antioxidant activity of propolis and its molecular mechanism].

Propolis is an adhesive substance mixed with plant resins collected by honeybees (Apis mellifera) and secretions from their mandibular gland and wax gland, with wide pharmacological activity and healthcare functions. Its antioxidant activity has long been regarded as one of the most important biological activities of propolis. This article summarizes studies on the antioxidant activity of propolis extracts from different geographic origins and with different extraction methods, as well as several important monomer active ingredients in propolis, and concludes the potential molecular mechanism of antioxidant activity of propolis and its monomer ingredients, with the aim of providing ideas for further studies on pharmacological activity of propolis, as well as reference for in-depth development of propolis products.

[Relationship between sleep quality and nocturnal pain in ankylosing spondylitis].

Objective: To evaluate the relationship between sleep quality and nocturnal pain in ankylosing spondylitis (AS) patients.

Methods: A total of 157 AS patients were recruited. Pittsburgh sleeping quality index (PSQI) and visual analogue scale (VAS) were used to assess sleep quality and nocturnal pain respectively.

[Inhibitory effect of human umbilical cord-derived mesenchymal stem cells on interleukin-17 production in peripheral blood T cells from spondyloarthritis patients].

In this study, the inhibitory effect of human umbilical cord-derived mesenchymal stem cells (hUCMSC) on interleukin-17 (IL-17) production in peripheral blood T cells from patients with spondyloarthritis (SpA) were investigated, in order to explore the therapeutic potential of hUCMSC in the SpA. Peripheral blood mononuclear cells (PBMNC) were isolated from patients with SpA (n = 12) and healthy subjects (n = 6). PBMNC were cultured in vitro with hUCMSC or alone.

[The efficacy of etanercept in enthesitis in ankylosing spondylitis and an evaluation method for enthesitis].

Objective: To evaluate the efficacy of etanercept in the treatment of active ankylosing spondylitis (AS) with enthesitis and explore an easy and accurate scoring method.

Methods: We designed this 12-week double-blind, placebo-controlled, randomized clinical study in active AS patients. The first part was a 6-week placebo-controlled period that patients received etanercept or placebo, followed by a 6-week open-label period that all patients received etanercept.

[The diagnostic significance of nailfold video-capillaroscopy in systemic sclerosis].

Objective: To observe nailfold capillary changes in a cohort of connective tissue disease (CTD) with Raynaud's phenomenon (RP) and to explore the diagnostic value of nailfold video-capillaroscopy (NVC) in systemic sclerosis (SSc).

Methods: Sixty CTD patients with RP divided into SSc group (n = 36) and non-SSc group (n = 24) were referred to an experienced operator for NVC.

Results: The patients had decreased capillary loops in SSc group with the capillary diameter more enlarged in SSc group than non-SSc group.

[Delayed hypersensitivity to infliximab retreatment in two patients and literature review].

Objective: To improve the understanding of severe anaphylactic reactions to infliximab retreatment.

Methods: Delayed hypersensitivity to infliximab in two patients with ankylosing spondylitis who had previously received infliximab and resumed after discontinuation over 4 years were reported and the related literatures were reviewed.

Results: Two patients (1 male, 1 female) who were diagnosed with ankylosing spondylitis for more than 10 years, both individuals had received infliximab treatment during a clinical trial approximately 4 - 5 years prior to further therapy.

[A randomized, single-blind, parallel, controlled clinical study on single intra-articular injection of etanercept in treatment of inflammatory knee arthritis].

Objective: To evaluate the efficacy and safety of single intra-articular etanercept injection in patients with rheumatoid arthritis (RA) and spondyloarthropathy (SpA) who had knee arthritis.

Methods: This was a randomized, single-blind, parallel, controlled clinical trial. The subjects were the RA or SpA patients with the knee arthritis without deformity, moderate or severe bone erosion and obvious joint space narrowing in radiography in the target knees, who had taken at least 6-week therapy with routine dosage of disease modifying anti-rheumatic drugs (DMARDs) before the study.

[The efficacy and safety of long-term thalidomide in the treatment of ankylosing spondylitis].

Objective: To investigate the long term efficacy and safety of thalidomide in the treatment of refractory ankylosing spondylitis.

Methods: A total of 232 patients with refractory ankylosing spondylitis were recruited into open study using thalidomide at a dose of 150 mg/d, bath ankylosing spondylitis disease activity index (BASDAI), spinal pain score and thalidomide related side effects were observed regularly.

Results: From the third month, BASDAI and spine pain score decreased significantly when compared with those of the base line (P<0.

Idiopathic retroperitoneal fibrosis (RPF): clinical features of 61 cases and literature review.

The objective of this study is to describe the clinical characteristics of patients with idiopathic retroperitoneal fibrosis (RPF). A retrospective analysis of patients diagnosed with idiopathic RPF in Chinese People's Liberation Army General Hospital was conducted. Sixty-one patients with idiopathic RPF were identified.

[The clinical characters of 30 patients with enteropathic arthritis and literature review].

Objective: To better understand the clinical characters of enteropathic arthritis patients.

Methods: The clinical, laboratory and X-rays data of 30 enteropathic arthritis in-patients were analyzed.

Results: Among the 30 patients, 14 were male, 16 were female.

[Idiopathic retroperitoneal fibrosis:clinical characteristics of 61 cases and literature review.].

Objective: We reviewed the data of 61 cases with idiopathic retroperitoneal fibrosis (IRF). The purpose was to understand the feature of the disease in order to improve its diagnosis and treatment.

Methods: The clinical data of 61 cases discharged from our hospital were analyzed retrospectively.