Publications by authors named "Jiang-hua Zhong"
Twin Phenomena of Hypertrophic Cardiomyopathy: A Reported Case Series.
Anatol J Cardiol
November 2024
Article Synopsis
- Hypertrophic cardiomyopathy (HCM) is a common genetic heart disease marked by thickening of the left ventricular wall, often seen in families with a genetic predisposition.
- The rarity of HCM in twins provides a unique insight into the genetic and environmental factors that can affect the disease's expression, even among genetically identical individuals.
- This review analyzes global clinical studies on HCM in twins, stressing the importance of genetic screening for early diagnosis and the potential for personalized treatment strategies based on a deeper understanding of HCM's genetic complexities.
Purpose Of Review: The primary objective of this review is to explore the pathophysiological roles and clinical implications of lipoprotein(a) [Lp(a)] in the context of atherosclerotic cardiovascular disease (ASCVD). We seek to understand how Lp(a) contributes to inflammation and arteriosclerosis, aiming to provide new insights into the mechanisms of ASCVD progression.
Recent Findings: Recent research highlights Lp(a) as an independent risk factor for ASCVD.
Article Synopsis
- Ischemic ulcers, common in patients with atherosclerosis, present complex challenges due to poor healing; this study aimed to understand how Transforming Growth Factor Beta 3 (TGF-β3) influences healing and inflammation in these ulcers.
- Conducted on 428 patients in Haikou, China, the research revealed that TGF-β3 levels varied through different healing stages, being higher in the inflammation phase and more pronounced in larger, deeper ulcers.
- Topical application of TGF-β3 showed promising therapeutic effects, improving ulcer healing by reducing depth and size, indicating its dual role in managing inflammation and promoting tissue repair.
Role of pyroptosis in diabetic cardiomyopathy: an updated review.
Front Endocrinol (Lausanne)
January 2024
Article Synopsis
- * Pyroptosis, a type of programmed cell death linked to inflammation, has been found to worsen the progression of DCM, suggesting its role in the condition's development.
- * The review summarizes mechanisms of how pyroptosis contributes to DCM and highlights potential treatments targeting the NLRP3 inflammasome, aiming to provide new insights for developing therapies for DCM.
Objective: To observe the effects of angiotensin Ⅱ(Ang Ⅱ) perfusion on transmural heterogeneity of Cx43 expression in the rabbit model with acute myocardial ischemia reperfusion (MIR), and investigate the role of rennin-angiotensin system in malignant ventricular arrhythmia induced by MIR.
Methods: Twenty rabbits were randomly divided into MIR group (n = 10) and Ang Ⅱ group (n = 10). MIR model was produced with traditional ligation and opening of the anterior descending coronary artery in all animal.
Objective: To investigate the protective effect of different cyclosporin A (CsA) doses on myocardial ischemia/reperfusion injury in rat models.
Methods: A rat model of myocardial ischemia/reperfusion injury was established in vivo and the rats were randomly divided into four groups: placebo (PBS; T1), low-dose (CsA dose: 1.0 mg/kg; T2), medium-dose (CsA dose: 2.
Article Synopsis
- - The study investigates how low potassium levels (hypokalemia) affect the electrical behavior of the heart's left ventricle in rabbits, particularly focusing on ventricular repolarization and the potential risk for dangerous heart rhythms (malignant ventricular arrhythmia).
- - Twenty rabbits were divided into control (normal potassium) and hypokalemic groups to test differences in electrical properties like action potential duration and ventricular fibrillation threshold, revealing significant alterations in the hypokalemic group.
- - Results showed that hypokalemia prolonged repolarization duration and reduced the voltage required to induce fibrillation, indicating an increased risk for serious heart arrhythmias, especially associated with changes in specific protein expression related to heart muscle function.
Aim: To study the effects of carvedilol on the transmural heterogeneity of ventricular repolarization in rabbits with congestive heart failure (CHF).
Methods: Rabbits were randomly divided into 3 groups: control, CHF and carvedilol treated CHF group. Monophasic action potential duration (MAPD) in the 3 myocardial layers was simultaneously recorded.
Effect of benazepril on heart rate turbulence in patients with dilated cardiomyopathy.
Clin Exp Pharmacol Physiol
July 2007
1. Heart rate (HR) turbulence describes short-term sinus rhythmic fluctuation after a single premature ventricular beat. Turbulence onset (TO) and turbulence slope (TS) are two essential parameters in HR turbulence.
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