Analysis of the Development Trend in Forensic Odontology Based on CiteSpace.

Objectives: To realize the dynamic visualization of forensic odontology based on the bibliometrics methods, and capture the research hotspots and identify the future development trend.

Methods: Literature articles published from January 1995 to December 2020 were searched according to specific subject words in the core data set of Web of Science. The visualization analysis of publishing country, institution, discipline, author, co-cited journal and keywords was performed by CiteSpace 5.

Activation of the Vpdm-VPM pathway contributes to anxiety-like behaviors induced by malocclusion.

Occlusal disharmony has a negative impact on emotion. The mesencephalic trigeminal nucleus (Vme) neurons are the primary afferent nuclei that convey proprioceptive information from proprioceptors and low-threshold mechanoreceptors in the periodontal ligament and jaw muscles in the cranio-oro-facial regions. The dorsomedial part of the principal sensory trigeminal nucleus (Vpdm) and the ventral posteromedial nucleus (VPM) of thalamus have been proven to be crucial relay stations in ascending pathway of proprioception.

Cellular Inflammatory Response of the Spleen After Acute Spinal Cord Injury in Rat.

Spinal cord injury (SCI) involves both primary and secondary damages. After the phase of primary injury, a series of inflammatory responses initiate, which belong to the secondary injury. There has been little investigation into the cellular inflammatory response of the spleen to SCI.

Expression of NG2 and platelet-derived growth factor receptor alpha in the developing neonatal rat brain.

Platelet-derived growth factor receptor alpha (PDGFRα) is a marker of oligodendrocyte precursor cells in the central nervous system. NG2 is also considered a marker of oligodendrocyte precursor cells. However, whether there are differences in the distribution and morphology of oligodendrocyte precursor cells labeled by NG2 or PDGFRα in the developing neonatal rat brain remains unclear.

Contents of Heavy Metals in Chinese Edible Herbs: Evidence from a Case Study of Epimedii Folium.

Toxic heavy metal contamination in Chinese edible herbs has raised a worldwide concern. In this study, heavy metals in Epimedii Folium, an edible medicinal plant in China, were quantitatively analyzed. Variations of heavy metals in different species, in various organs (i.

[The role of histone acetylation in the basolateral amygdala in morphine-associated memory in rats].

To examine the regulatory effect of histone acetylation on memory related molecules, 34 healthy male SD rats were randomly divided into control and basolateral amygdala (BLA) intracranial positioning operation groups. In the process of conditioned place preference (CPP) training, Trichostafin A (TSA) was administrated by the route of BLA and morphine was injected into enterocoelia with dimethyl sulfoxide or saline as control. Expression levels of H3K14 acetylation and brain-derived neurotrophic factor (BDNF) in BLA were evaluated by Western blotting.

Analysis of variations in the glutamate receptor, N-methyl D-aspartate 2A (GRIN2A) gene reveals their relative importance as genetic susceptibility factors for heroin addiction.

The glutamate receptor, N-methyl D-aspartate 2A (GRIN2A) gene that encodes the 2A subunit of the N-methyl D-aspartate (NMDA) receptor was recently shown to be involved in the development of opiate addiction. Genetic polymorphisms in GRIN2A have a plausible role in modulating the risk of heroin addiction. An association of GRIN2A single-nucleotide polymorphisms (SNPs) with heroin addiction was found earlier in African Americans.

Association of TNF-α and Fas gene promoter polymorphism with the risk of Kashin-Beck disease in Northwest Chinese population.

The objective of this study is to investigate the relationship between single-nucleotide polymorphisms (SNPs) of the tumor necrosis factor-α (TNF-α) and Fas genes and Kashin-Beck disease (KBD) in Shaanxi province, Northwest in China. Blood samples of 388 residents were collected from 14 KBD villages in Linyou and Yongshou counties, Shaanxi, Northern of China. One hundred eighty-six cases with KBD and 202 cases of health in KBD areas were diagnosed by "Diagnosis Criterion of Kashin-Beck disease in China (WS/T207- 2010)".

[Association between polymorphism in DVWA and IL-1beta and Kashin-Beck disease].

Objective: To investigate the association between IL-1beta and DVWA gene and Kashin-Beck disease (KBD).

Methods: Peripheral genomic DNA were extracted from 105 patients with KBD and 98 healthy controls. PCR-RFLP were performed to detect SNP loci of IL-1beta gene and DVWA gene.

[Genetic structure of X-STR loci in Bai, Dai and Yi ethnic groups and their affinity with five major populations of China].

To determine the genetic polymorphism of three X-STR loci for Bai, Dai, Yi ethnic groups from Yunnan Province, DXS6804, DXS6799 and DXS7132 were genotyped by multiplex PCR and Genscan. Eighteen alleles and thirty-eight genotypes were detected in 89 Bai unrelated persons. The gene frequencies ranged from 0.

[Genetic polymorphisms and application of 9 STR loci of 5 ethnic groups in Gansu and Qinghai].

Objective: To examine the genetic polymorphism of 9 STR loci in 5 ethnic groups (including Tu, Sala, Dongxiang, Baoan and Yugu) in Gansu and Qinghai, and to evaluate its application.

Methods: Nine STR loci (D3S1358, FGA, TH01, D7S820, VWA, CSF1PO, D5S818, D13S317 and TPOX) were selected as genetic markers. With STR compound amplification and genescan methods, in which STR loci were marked by fluorescence, the genotype of 5 ethnic groups were examined in 606 unrelated individuals by ABI 377 sequencer.

[Analysis of allele frequencies of 6 short tandem repeat loci on chromosome 12 in patients with Kashing-Beck disease].

Objective: To analyze the allele frequencies of 6 STR loci (D12S358, D12S1675, D12S1663, D12S1697, D12S16725 and D12S1613) on chromosome 12 among KBD patients and residents in the KBD and non-KBD areas.

Methods: EDTA-blood samples were collected from 146 unrelated Chinese Han individuals in Shaanxi Province including 57 KBD patients, 48 control subjects living in the Kashing-Beck disease(KBD) area and 48 in the non-KBD area. The DNA samples were extracted and amplified by PCR, and the PCR products were analyzed by ABI 3100 Genetic Analyzer.

[The genetic polymorphism of 9 short tandem repeat loci in Yi ethnic group of Yunnan in China].

Objective: To study the short teadem repeat(STR) genetics structure of a Chinese Yunnan Yi racial group.

Methods: Genetic distributions for nine STR loci were determined based on STR gene scan marked by fluorescence.

Results: Sixty-nine alleles and 164 kinds of genotypes were detected and identified from 84 unrelated Yi racial individuals.

[Analysis of genetic polymorphism of 7 STR loci on chromosome 12 in Shaanxi Han populations].

To analyze the genetic polymorphism of 7 STR loci (D12S1718,D12S1675, D12S358, D12S367, D12S1638, D12S1646 and D12S1682) on chromosome 12 in Shaanxi Hans. EDTA-blood specimens were collected from 80 unrelated individuals from Chinese Han population in Shaanxi province. The DNA samples were extracted and relevant fragments were amplified by polymerase chain reaction (PCR).

[Study on 9 STR loci polymorphism from Chinese Yao ethnic group(Guangxi)].

Genetic polymorphism of nine STR loci was investigated from a Chinese Yao population based on STR Genescan. Sixty one alleles was determined for 9 loci, such as D3S1358,vWA,FGA,THO1,TPOX,CSF1P0,D5S818,D13S317 and D7S820 with their frequencies 0.0054-0.

[Genetic polymorphisms of 9 STR loci in Dongxiang ethnic group of China].

Genetic distribution for nine STR loci was determined in a Chinese Dongxing ethnic group based on STR genescan marked by fluorescence. Seventy-two alleles and 182 genotypes were observed in 94 unrelated Chinese Dongxiang individuals,with the corresponding gene frequency and genotype frequency being 0.0053-0.

[Polymorphism of nine STR locus in Nu population from Yunnan Province].

In this study,blood samples were randomly drawn from 84 unrelated Nu individuals. The polymorphism of nine STR loci and Amelogenin locus were determined by DNA GeneScan. The genetic database on the distribution of gene frequency on the nine STR loci was established, statistical results showed that the genotype distributions were in agreement with Hardy-Weinberg equation.

[Analysis on HLA haplotypes of loci HLA-A, -B, and -DRB1 in northwest Chinese Han population].

Objective: To investigate HLA-A, -B and -DRB1 allele and HLA-A-B, B-DRB1, A-B-DRB1 haplotype frequencies in the northwest Chinese Han population.

Methods: The authors investigated the HLA-A, -B, -DRB1 allele and haplotype in a northwest Chinese Han population based on 62 families and 101 individuals by use of PCR-sequence specific oligonucleotide probes(PCR-SSOP) DNA typing methods.

Results: Fifteen alleles for the locus HLA-A, 28 alleles for the HLA-B locus and 13 alleles for the HLA-DRB1 were detected.

[Genetic polymorphism of 9 STR loci in Chaoxian National Minority of China].

In order to enrich the Chinese genetic database,nine polymorphic loci of STR,such as D3S1358,vWA,FGA,TH01,TPOX,CSF1PO,D5S818,D13S317 and D7S820 were studied. Based on STR gene scan marked by fluorescence,91 unrelated Chinese Chaoxian individuals were observed.81 alleles and 196 genotypes were found.

[The study on HLA-Cw polymorphism from Xi'an Han population by PCR-sequence specific oligonucleotide probe].

Objective: To determine the HLA-Cw allele and genotype frequencies from Xi'an Han population and obtain genetic data.

Methods: The results of HLA-Cw typing for 130 randomly selected from Xi'an Han population were obtained by using the PCR-Sequence Specific Oligonucleotide Probes (SSOP).

Results: In this investigation, 16 alleles were detected among 130 unrelated individuals with frequencies from 0.

[The study of HLA-Cw polymorphism in Uygur population].

The HLA-Cw loci polymorphism in Uygur population was investigated using the PCR- sequence specific oligonucleotide probe (SSOP) method,and the genetic database on the distribution of gene frequency of the HLA-Cw loci was established. From 146 individuals of Uygur population,18 HLA-Cw alleles were detected. The gene frequency was from 0.

[Genetic polymorphism of 9 STR loci in Zhuang national minority of China].

Genetic distribution for nine STR loci were determined in a Chinese Guangxi Zhuang national minority group based on STR gene scan marked by fluorescence. Sixty-two alleles and 169 genotypes were observed in 91 unrelated Zhuang individuals. The corresponding gene frequency and genotype frequency were 0.

[Studies of STR polymorphisms in Pumi and Lisu minorities in China].

In this study, we investigated the polymorphisms of STR of Pumi and Lisu minorities with STR genescan marked by fluorescence. Eighty-five alleles of 9 STR in Pumi were detected with the frequency 0.0050-0.

[STR polymorphisms in four Xinjiang ethnic groups in China].

Population genetic studies were performed in Xinjiang's Uygur, Sibe, Ozbek and Kirgiz. Allele frequency distributions were analyzed for ten loci, i.e.

[Genetic structure of STR in Naci ethnic group in China].

STR is a universal genetic marker that has changeable polymorphism and stable heredity in human genome. It is a specific DNA segment composed of 2-7 base pairs as its core sequence, and is formed through the repeated connection of the same one. Since it has the characteristics such as numerous allelic genes, highly heterozygosity and easy recognition and short PCR segment, it is employed as an ideal DNA marker in such practical fields as human genetics and forensic medicine.