Danshen modulates Nrf2-mediated signaling pathway in cisplatin-induced renal injury.

Danshen, an efficacious agent for cardiovascular diseases, has been found to play an essential role in kidney injury. In the present study, the effect of Danshen on cisplatin-induced renal dysfunction was investigated in a mouse model. Danshen was administered to mice at a dose of 3 g/kg 4 days before and 3 days after cisplatin treatment.

The influence of mutant lactobacilli on serum creatinine and urea nitrogen concentrations and renal pathology in 5/6 nephrectomized rats.

Objectives: To explore the capacity of mutant lactobacilli to remove creatinine (Cr) and urea nitrogen (UN) via the gastrointestinal tract and its effects on renal pathology in the 5/6 nephrectomized rat model of chronic renal failure.

Methods: Sixty Sprague-Dawley rats were randomly divided into a Sham group, a Model group, a wide-type Lactobacilli group (L.B group), and a Mutant Lactobacilli group (Mut-L.

Lactobacillus bulgaricus mutants decompose uremic toxins.

Background/aims: We aim to obtain a probiotic strain from Lactobacillus bulgaricus by testing its capability to decompose uremic toxins to provide new intestinal bacteria for the treatment of chronic renal failure.

Methods: Original L. bulgaricus was cultured with the serum of uremic patients and then mutated by physical (ultraviolet) and chemical (diethyl sulfate) methods repeatedly.

Shenfushu granule and atropine attenuate microvasculature loss in rat models with 5/6 nephrectomy.

Objective: To investigate the effect of Shenfushu granule (SFSG) and atropine treatment on microvessels of the kidney and intestine after chronic renal failure (CRF) induced by 5/6 nephrectomy.

Methods: Sprague Dawley rats were randomly divided into a sham group, a model group, an SFSG group, and an SFSG + atropine group. SFSG was administered daily 1 week after inducing CRF.

Isolation and characterization of polymorphic microsatellite loci in Camellia nitidissima Chi (Theaceae).

Premise Of The Study: Microsatellite markers were developed in Camellia nitidissima for further population genetic studies. •

Methods And Results: Eight microsatellite markers were newly developed from C. nitidissima and 7 were transferred from other Camellia species.

[Effect of potassium iodide on prevention of experimental lead nephropathy and expression of nuclear factor-kappaB and fibronectin].

Objective: To investigate the effect of potassium iodide on the expression of nuclear factor-kappaB and fibronectin.

Methods: The experiment was performed with 72 SD rats weighing about 180-220 g. The animals were randomly assigned into nine groups.

[Investigation and controlling measure of main diseases and pests on Artemisia annua].

According to the investigations in Guangxi area, there are 3 kind diseases and 11 kind insect pests on Artemisia annua L. In which main diseases and peste are the stem rot, cataplexy, Myzus persicase, Agrotis ypsilon and Diarthronomyia chrysanthemi. This article reports the main symptom, the cause of disease, the shape characteristic, the harm situation emphatically as well as the preventing and controlling measure.

[Effect of benazepril on the VEGF and MVD in the remnant kidney of 5/6 subtotal nephrectomized rats].

Objective: To explore the effect of benazepril (one of angiotesin converting enzymes) on the expression of vascular endothelial growth factor (VEGF) and the change of microvessel density (MVD) in the remnant kidney of rats that undergone 5/6 subtotal nephrectomy (STNx).

Methods: The male Sprague-Dawley (SD) rats were performed 5/6 nephrectomy to produce chronic renal failure, and randomly divided into a model group (STNx group), a STNx combined with benazepril group (Benazepril group), and a sham group that served as normal controls. Pathological changes of the remnant kidney were evaluated at the 8th week after gastric gavage.

[Expression of renal nuclear factor-kappaB, transforming growth factor-beta and fibronectin of rats exposed to lead].

Objective: To investigate the role of lead in the expression of the renal fibrosis related nuclear factor kappaB (NF-kappaB), transforming growth factor (TGF-beta) and fibronectin (FN) in rat kidney and the possible molecule mechanism of lead induced renal fibrosis.

Methods: Thirty-two Sprague-Dawley rats were randomized into 4 groups. Group A was fed with distilled water as control group.

[Multiple analysis of lead concentration in the air and renal function of lead exposure workers].

Objective: To determine the lead concentration in the air (pbA) at the workplace and the renal function of lead exposure workers.

Methods: The lead concentration in the air of 11 printing plants, 4 smelteries and 2 lead mines were measured. Screening urinalysis was performed in 1190 long term lead exposed workers with urine sugar, protein and sigements.

[A comparison of the activities of membrane-bound, proton translocating ATPases between Streptococcus mutans fluoride-resistant and their parent strains].

Purpose: To figure out the reason for increased acid tolerance of Ingbritt-FR, the fluoride-resistant strain of Streptococcus mutans Ingbritt, by determining and comparing the H(+)-ATPase activities of both fluoride-resistant and their parental strains.

Methods: The permeabilized cells of S. mutans Ingbritt and Ingbritt-FR were prepared by treating them with 10% toluene and then two cycles of freezing and thawing.

[Comparison of effect on S.mutans producing acid ability between organic weak acid and fluoride].

Objective: To figure out the effects of organic weak acids, benzoate, citric acid and malic acid on the main cariogenic bacteria S.mutans Ingbritt. To evaluate the possibility of above weak acids as anti-caries reagents.

[Adsorbent effect of activated carbon on small molecular uremic toxin and its influence factors].

Objective: To analyze the adsorbent effect of activated carbon on uremic toxin and its influence factors.

Methods: Uremic toxins (urea, creatinine and uric acid) were dissolved in the distilled water to obtain uremic toxic solution. Activated carbon was added to the solution, and the concentrations of uremic toxins were measured at different time spots.