Publications by authors named "Jiang-Yan Chen"
Article Synopsis
- - The study investigates the pharmacokinetic differences of twelve key constituents in the herbal remedy Qihe Fenqing Yin, focusing on their behavior in normal versus diabetic rats, which were induced using a high-fat diet and streptozocin injections.
- - A specialized UHPLC-QTRAP-MS/MS method was developed to analyze the constituents in rat plasma after administering the herbal remedy, demonstrating the method's reliability in terms of linearity, accuracy, and stability.
- - Results indicate that most constituents show prolonged half-lives in diabetic rats compared to normal rats, and significant differences in the area under the curve (AUC) and mean residence time (MRT) were observed, highlighting altered pharmacokinetics in disease states. *
Omega-3 has been proposed as an antitumor substance that suppresses the growth and metastasis of multiple types of tumor cells, including lung cancer, but the specific mechanisms involved remain obscure. Our previous studies showed that the expression of chemokine ligand 18 was related to the migration and metastasis of non-small cell lung cancer. Here, we aim to explore whether omega-3 inhibits invasion and metastasis of NSCLC by regulating the expression of CCL18.
View Article and Find Full Text PDFGinger powder (GP) is a popular spice in the world. Duo to its nutritional value, GP is regarded as an attractive target for adulteration, which is not easily detected. In this study, chromaticity analysis and Fourier transform near-infrared (FT-NIR) spectroscopy combined with chemometrics were developed to identify and quantify of GP and its adulterants.
View Article and Find Full Text PDFHome blood pressure (BP) monitoring is a useful tool for hypertension management. BP variability (BPV) has been associated with an increased risk of cardiovascular events. However, little is known about the correlation between BPV and different measurement patterns of long-term home BP monitoring.
View Article and Find Full Text PDFArticle Synopsis
- Fusion core proteins of Hepatitis B virus (HBV) can aid in understanding core protein functions and their movement within cells.
- A method was developed to create these fusion proteins that retains some functionality by using long Glycine-serine linkers and attaching proteins at the N terminus of HBc.
- The study found that the GFP-GS186-HBc and RFP-G4S47-HBc fusion proteins helped rescue HBV replication but did not support the formation of relaxed circular DNA, indicating their potential use for tracking HBc and capsid activity in research.