Publications by authors named "Jiang-Xin Hu"

Differences in the distribution of hydrophilic and hydrophobic bile acids (BA) are observed in mouse models of non-alcoholic fatty liver disease (NAFLD) induced by a high-fat-cholesterol "Western-style" diet (WD), and cholesterol gallstone disease (CGD) induced by a lithogenic diet. Despite sharing common pathological processes, these models exhibit distinct characteristics in their BA pools. The study investigates the impact of hydrophobic BA (BA) and hydrophilic BA (BA) on CGD development using cytochrome-P450-2c70 knockout (C70-KO) mice (mice), genetically modified to resemble humans with a hydrophobic BA pool.

View Article and Find Full Text PDF

Purpose: Despite significant advancements in the treatment of acute ischemic stroke (AIS) with endovascular thrombectomy (EVT), post-EVT mortality remains a considerable concern. However, there is a lack of real-world epidemiological data delineating the characteristics of mortality for EVT, particularly in recent years following the widespread promotion of EVT treatment for stroke patients.

Methods: This multicenter, retrospective study collected data from 721 AIS patients who died following EVT across 33 hospitals in Sichuan Province, China, from January 2019 to September 2022.

View Article and Find Full Text PDF

The incorporation of reversible sacrificial bonds is an important strategy for enhancing the mechanical properties of elastomers. However, the research on the viscoelasticity of vulcanized rubber with a reversible sacrificial bond network lags seriously. In this paper, the effects of metal coordination bonds on the mechanical properties of butadiene-styrene-vinylpyridine rubber vulcanizates (VPR) were systematically investigated.

View Article and Find Full Text PDF
Article Synopsis
  • Growing evidence shows that using manure with residual antibiotics increases soil antibiotic resistance genes (ARGs), but the impact of long-term antibiotic-free fertilization is not well understood.
  • This study found that while long-term fertilization affects the diversity of ARGs minimally, antibiotic-free manure leads to lower increases in ARG abundances compared to chemical fertilizers.
  • However, combining antibiotic-free manure with chemical fertilizers resulted in higher nutrient levels and enhanced certain microbial populations, indicating that while antibiotic-free practices help reduce risks, they don’t completely eliminate ARGs, suggesting a need for broader strategies in agriculture to combat antibiotic resistance.
View Article and Find Full Text PDF

The improvement of coastal saline land would alleviate the problem of insufficient arable land and provide new solutions for guaranteeing food security and ecological environment modification. In this study, five typical soil samples were collected from Tongzhou Bay, China. The changes in bacterial, animal and plant community composition before and after improvement were comprehensively investigated by a combination of high-throughput sequencing and macro-barcode sequencing analysis of eDNA.

View Article and Find Full Text PDF

The management of chronic kidney disease (CKD) is a global health challenge. Elevated levels of inflammatory cytokines, including interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), are associated with higher mortality rates in patients with CKD. Moreover, increased fibroblast growth factor 23 (FGF23) levels are a strong predictor of adverse clinical outcomes in CKD.

View Article and Find Full Text PDF

L-Boronophenylalanine (BPA), a widely used B carrier for clinical boron neutron capture therapy (BNCT), was quantified in rat plasma through a simple, effective and stable ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method. Chromatographic separation was performed on an ACQUITY UPLC HSS T3 (100 mm × 2.1 mm, 1.

View Article and Find Full Text PDF

Prostate cancer is one of the most common cancers in men and poses a significant threat to global male health. Traditional prostate cancer assessment methods have certain limitations, necessitating the identification of new prognostic factors and treatment targets. Our study revealed that low expression of the cornichon family AMPA receptor auxiliary protein 2 (CNIH2) gene was associated with a better progression-free survival rate in prostate cancer patients.

View Article and Find Full Text PDF
Article Synopsis
  • The SHE study investigates the effectiveness and safety of combining selective endovascular brain hypothermia with edaravone dexborneol in treating acute ischemic stroke (AIS).
  • It is a multicenter, single-blind, randomized controlled trial involving 564 patients who received endovascular treatment within 24 hours of stroke onset.
  • The primary goal is to determine if this combination therapy results in better functional independence (measured by mRS score) at 90 days compared to edaravone dexborneol alone.
View Article and Find Full Text PDF

Background: Prostate cancer is one of the most common malignancies in men worldwide, and prostate-specific antigen (PSA) screening is widely used for its early detection. Drug use may affect PSA levels, but the effect for most drugs is currently unknown.

Methods: This study first investigated drugs related to PSA changes through the Food and Drug Administration Adverse Event Reporting System (FAERs) database, and then used a Mendelian randomization (MR) method to explore the causal relationship between specific drugs and PSA changes using a genome-wide association study (GWAS) data.

View Article and Find Full Text PDF

Background: Endovascular treatment (EVT) has been demonstrated to be effective for patients with tandem occlusion. The efficacy and safety of intravenous thrombolysis before EVT in patients with tandem occlusion remain debatable.

Methods And Results: We conducted a systematic review and meta-analysis with PubMed, EMBASE, and the Cochrane Library from inception to September 2023.

View Article and Find Full Text PDF
Article Synopsis
  • - Multi-resistant Staphylococcus aureus (S. aureus) poses a serious global health threat, with high rates of illness and death; the enzyme coagulase (Coa) is a critical factor in its ability to cause infections.
  • - Sinigrin has been identified as an effective Coa inhibitor that can significantly impair S. aureus coagulation and disrupt its protective mechanisms, with notable effects observed at concentrations as low as 32 mg/L.
  • - In tests on mice, sinigrin combined with the antibiotic oxacillin proved more effective against S. aureus pneumonia than oxacillin alone, reducing bacterial counts and inflammation, suggesting sinigrin's potential as a complementary treatment in antimicrobial therapies. *
View Article and Find Full Text PDF

The metal-catalyzed sulfur reaction in lithium-sulfur (Li-S) batteries usually suffers from the strong binding of sulfur species to the catalyst surface, which destroys the electric double layer (EDL) region there. This causes rapid catalyst deactivation because it prevents the desorption of sulfur species and mass transport through the EDL is hindered. This work introduces a competitive adsorption factor (f) as a new indicator to quantify the competitive adsorption of sulfur species in the EDL and proposes an alloying method to change it by strengthening the p-d hybridization of alloying metals with electrolyte solvents.

View Article and Find Full Text PDF

Due to intrinsic defensive response, ferroptosis-activating targeted therapy fails to achieve satisfactory clinical benefits. Though p62-Keap1-Nrf2 axis is activated to form a negative feedback loop during ferroptosis induction, how p62 is activated remains largely unknown. MTS assay was applied to measure cell growth.

View Article and Find Full Text PDF

APOE ε4 is risk for cognitive decline even in normal aging, but its effect on the whole-brain functional connectivity (FC) among time in young adults remain elusive. This study aimed to validate the time-by-APOE ε4 interaction on brain FC of this specific population. Longitudinal changes in neuropsychological assessments and resting-state functional magnetic resonance imaging in 26 ε4 carriers and 26 matched non-ε4 carriers were measured for about 3 years.

View Article and Find Full Text PDF

Compared with the ever-growing information about the anthropogenic discharge of nutrients, metals, and antibiotics on the disturbance of antibiotic resistance genes (ARGs), less is known about how the potential natural stressors drive the evolutionary processes of antibiotic resistance. This study examined how soil resistomes evolved and differentiated over 30 years in various land use settings with spatiotemporal homogeneity and minimal human impact. We found that the contents of soil organic carbon, nitrogen, soil microbial biomass, and bioavailable heavy metals, as well as related changes in the antibiotic resistome prevalence including diversity and abundance, declined in the order of grassland > cropland > bareland.

View Article and Find Full Text PDF

Aims: Infection is a common complication following acute ischemic stroke (AIS) and significantly contributes to poor functional outcomes after stroke. This study aimed to investigate the effects of infection after endovascular treatment (post-EVT infection) on clinical outcomes and risk factors in patients with AIS.

Methods: We retrospectively analyzed AIS patients treated with endovascular treatment (EVT) between January 2016 and December 2022.

View Article and Find Full Text PDF

Maternal nutritional deficiencies during pregnancy result in birth defects and elevate the risk of cardiovascular diseases and metabolic diseases. Accumulating evidence suggests that deficiency of copper, a fundamental trace element involved in several pivotal physiological processes, promotes the onset of multiple diseases, notably heart and liver diseases. Yet, exploration into the effects of maternal copper deficiency (CuD) on offspring is still limited.

View Article and Find Full Text PDF

Background: The present meta-analysis aimed to evaluate the efficacy and safety of adding nimotuzumab to radiotherapy (RT) or chemoradiotherapy (CRT).

Methods: Prospective randomized controlled studies at EMBASE, PubMed, and the Cochrane Library from January 1, 2010, to October 1, 2022, were searched. Data on the overall survival (OS), progress-free survival (PFS), disease-free survival (DFS), complete response rate (CRR), objective response rate (ORR), and all grade adverse events were collected from the enrolled publications.

View Article and Find Full Text PDF

Background: Polyphyllin, a natural compound derived primarily from the genus, manifests its anticancer properties. Extensive research on its therapeutic potential in cancers has been reported. However, there is no systematical analysis of the general aspects of research on polyphyllin by bibliometric analysis.

View Article and Find Full Text PDF

Background: The association of systolic blood pressure (SBP) and ischemic stroke outcome has recently been proved to be varied at different time points within 72 h after acute ischemic stroke onset; however, the specific status of how SBP affects prognosis at different time points within 72 h after endovascular treatment (EVT) among patients with large vessel occlusion (LVO) remains unclear.

Methods: Consecutive LVO patients treated with EVT were enrolled in our study. BP data were collected at eight time points (1, 2, 4, 8, 16, 24, 48, and 72 h post-EVT).

View Article and Find Full Text PDF

Background: The lack of randomized evidence makes it difficult to establish reliable treatment recommendations for endovascular treatment (EVT) in elderly patients. This meta-analysis aims to evaluate the therapeutic effects of endovascular treatment for acute ischemic stroke in the elderly compared with younger patients.

Methods: Comprehensive literature retrieval was conducted to identify studies that directly compared the outcomes of EVT in elderly patients and those aged <80 years.

View Article and Find Full Text PDF

Bacterial infection remains a big concern in the patients of ICU, which is the main cause of life-threatening organ dysfunction, or even sepsis. The poor control of bacterial infection caused by antibiotic resistance, etc. or the overwhelming immune response are the most important patho genic factors in intensive care unit (ICU) patients.

View Article and Find Full Text PDF
Article Synopsis
  • - The study examines how hearing loss affects cognitive function in older adults, focusing on the roles of self-rated health and depressive anxiety symptoms as mediators.
  • - Conducted with 624 participants aged 65+, the research utilized various assessments including the Mini-Mental State Examination and depression scales to analyze the data.
  • - Findings reveal that hearing loss has a direct negative impact on cognitive function, and self-rated health along with anxiety symptoms contributes to this decline; addressing these factors may help slow cognitive deterioration in those with hearing loss.
View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_session3nbvae1l96bln235of6n0e1i8lkm45sl): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once