Publications by authors named "Jiang-Lin Xiang"
Purpose: To investigate potential differences in clinical and computed tomography (CT) features between patients with the SARS-CoV-2 Omicron variant and the original strain.
Patients And Methods: This retrospective study included 69 hospitalized patients infected with Omicron variant from November to December 2022, and 96 hospitalized patients infected with the original strain from February to March 2020 in Chongqing, China. The clinical features, CT manifestations, degrees of lung involvement in different stages on CT, and imaging changes after the reverse-transcription polymerase chain reaction (RT-PCR) results turned negative were compared between the two groups.
Article Synopsis
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19 and is primarily diagnosed using real-time RT-PCR, which has some accuracy limitations.
- Researchers developed a new peptide-based luminescent immunoassay that detects IgG and IgM antibodies to improve detection.
- The immunoassay showed positive rates of 71.4% for IgG and 57.2% for IgM in confirmed patients, suggesting it could enhance COVID-19 diagnosis when used alongside RT-PCR.
Article Synopsis
- In December 2019, COVID-19 caused by the novel coronavirus emerged in Wuhan, China, with limited information on its clinical and immunological effects in children.
- A study analyzed twelve pediatric COVID-19 patients, revealing that common symptoms were cough (75%) and fever (58.3%), while children exhibited a longer incubation period (average of 8 days) compared to adults.
- The immune profiles indicated that children had higher levels of T cells and B cells, which may relate to their milder symptoms, and it is recommended that testing for SARS-CoV-2 be conducted for children with potential exposure, regardless of symptoms.
Article Synopsis
- The study analyzed the antibody responses of 285 COVID-19 patients, finding that all tested positive for IgG within 19 days of symptom onset.
- IgG and IgM antibodies either developed at the same time or one after the other, reaching stable levels within 6 days post-seroconversion.
- Serological tests could aid in diagnosing COVID-19, especially in cases with negative RT-PCR results and in detecting asymptomatic infections.