Publications by authors named "Jiang-Jun Ma"
Article Synopsis
- The study investigates the effectiveness of 75 genetic variants linked to colorectal cancer (CRC) in a Chinese population, focusing on the development of a predictive model.
- A risk prediction model that incorporates 19 variants showed some clinical benefits, achieving a moderate accuracy with AUC values between 0.59 and 0.61 during validation.
- Individuals in the highest risk quartile had more than double the likelihood of developing CRC compared to those in the lowest risk quartile, suggesting that this genetic model could help tailor CRC prevention strategies for individuals in China.
Article Synopsis
- This study analyzed the clinical outcomes of 366 patients with locally advanced laryngeal and hypopharyngeal cancers, comparing those who underwent total laryngectomy to those who received larynx preservation treatment.
- No significant differences were found in 3-, 5-, and 10-year progression-free survival (PFS) and overall survival (OS) rates between the two groups, though some differences were noted based on T stage.
- The findings suggest that larynx preservation approaches are not worse than surgery and highlight the need for assessing the effectiveness of chemotherapy regimens used in conjunction with radiotherapy.
Aberrant methylation of some genes can serve as promising biomarkers in hepatocellular carcinoma (HCC). This study aimed to investigate the diagnostic and prognostic value of plasma SGIP1 methylation in HCC. The study included a total of 269 subjects, of which 129 were with HCC, 45 with liver cirrhosis (LC), 45 with chronic hepatitis B (CHB), and 50 were healthy controls (HCs).
View Article and Find Full Text PDFThere is a compelling need to identify novel genetic variants for papillary thyroid cancer (PTC) susceptibility. The Cancer Genome Atlas (TCGA) data showed associations between SPP1 and SPARC mRNA overexpression and aggressive behaviors of PTC, which prompted us to assess potential associations between genetic variants in these genes and PTC risk. Three highly linked SPARC loci (rs1054204, rs3210714, and rs3549) contributed to reduced PTC risk under a codominant model (odds ratio [OR], 0.
View Article and Find Full Text PDFThe long non-coding RNA (lncRNA) GAS8-AS1 is the second-most frequently altered gene, following the BRAF gene, in papillary thyroid carcinoma (PTC). We aimed to study the specificity and significance of genetic alterations in GAS8-AS1 in PTC. In this study, we reported the prevalence of genetic alterations of GAS8-AS1 in tissues of 48 nodular goiter, 573 papillary thyroid cancer, 95 colorectal cancer, 101 non-small cell lung cancer, 92 glioma, and 69 gastrointestinal stromal tumor patients, and in peripheral white blood cells of 286 healthy volunteers.
View Article and Find Full Text PDFPurpose: To identify how Epstein-Barr virus (EBV) status combined with molecular profiling predicts the prognosis of gastric cancer patients and their associated clinical actionable biomarkers.
Experimental Design: A next-generation sequencing assay targeting 295 cancer-related genes was performed in 73 EBV-associated gastric cancer (EBVaGC) and 75 EBV-negative gastric cancer (EBVnGC) specimens and these results were compared with overall survival (OS).
Results: PIK3CA, ARID1A, SMAD4, and PIK3R1 mutated significantly more frequently in EBVaGC compared with their corresponding mutation rate in EBVnGC.
Introduction: Nasopharyngeal carcinoma (NPC) is a distinct type of head and neck cancer which is mostly prevalent in southern China. The development of NPC involves accumulation of multiple genetic changes. Chromosomal translocation is always thought to be accompanied with the fusion chimeric products.
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